radical rethink: elastase inhibitors

My wife turned this link up researching LDN (low dose naltrexone). I think this re-discovery and topic discussion here might cause IH to re-reformulate the top 6??

Where do elastase inhibitors fit into IH's recommended protocol? [emu oil, LDN ????]

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from: http://www.hairlosshelp.com/forums/messageview.cfm?catid=10&threadid=50115&highlight_key=y&keyword1=low%20dose%20naltrexone
07/21/2005

1) minoxidil is an elastase inhibitor if you didnt know
2) elastin is involved in keeping the hair or loosing it
3) elastase degrades elastin
4) most of the effective topical remidies that are not DHT inhibitors are elastase inhibitors (ie: emu oil)

So my regimine for my illness, and hair loss / regrowth is this :
low dose naltrexone (www.lowdosenaltrexone.org) - this will take awile to explain but basically it boosts endorphins and the immune system and it frikin works and is cheap. Ask questions or goto the yahoo group. it STOPS multiple sclerosis and cancers etc. There was a worldwide conference in NYC eariler in the month and one of the presentors of the compuding pharmacies noted that several people are using it for "alopecia". This is when i started researching.

So i use LDN, but i also am using several elastase inhibitors, such as rosemary extract, butchers broom, green tea, and beta lactum antibiotics, all proven elastase inhibiors, systmatically, and lo and behold no more androgentic alopecia!

I propose that the theory of DHT directly causing androgentic alopecia is false. DHT only comes in AFTER elastase degrades the hair connection/tip/follicle. Or alternatively, DHT is increased due to elastase. Stress will bring more elastase, and 5 alpha reductase. Remember that DHT, 5ALPHA is also related to modulation of GABA! So stress really does contribute to hair loss, as does DHT, but elastase is the key element that we are missing.

I suggest elastase inhibitors as a possible treatment for alopecia...
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I found this LDN board: http://ldn.proboards.com/index.cgi

curt

curt504 - LDN is great for idiopathic autoimmune disorders. However, I found have that in most cases there is a cause that can be identified for autoimmune disorders, include hair loss.

The only thing LDN would be useful for is for idiopathic alopecia areata.

Many of these autoimmune disease have overlooked underlying causes such as wheat/gluten (subclinical celiac disease), root canals, metal toxicity, body or dental implants, and heavy metal burden within the cerebral spinal fluid, or mycotoxins.

CS,
The only way to detect a heavy metal burden within the cerebro-spinal fluid would be thru lumbar punctar, correct? And if a substantial burden was found, would oral chelation work or would you have to use a more direct method?

Organisms such as P. aeruginosa also produce elastase..Is this one found in sebum?

squeegee wrote:Organisms such as P. aeruginosa also produce elastase..Is this one found in sebum?

Yes! I think we are on something that we should discuss more.. I discussed about it a couple months ago on HLT.. http://www.hairlosstalk.com/interact/viewtopic.php?f=42&t=51123&start=0&st=0&sk=t&sd=a

This is maybe why some people having success regrowing hair with Miconazole and Clotrimazole which are both anti-elastase...

http://www.biomedcentral.com/1472-6882/9/27

Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants

LDN seems to be useful for a number of autoimmune diseases.

Any way to get ldn without a script? (no insurance myself)

squeegee wrote:http://www.biomedcentral.com/1472-6882/9/27

Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants

Fresh White Tea applied to the scalp anyone?

From what I've read, LDN is inexpensive, somewhere around $25-30 a month.

Any ideas where to get it (LDN)? I could use it for other problems besides hair loss and would be interested to see if it would help that. Like they say, if you don't have your health...

Depends if the white tea has any flouride in it.

It seems like there are some new angles brewing to re-defining what's currently causing hair loss and what (may) work against it.

Anti-elastase
Astressin-B
β-catenin pathway
L-Threo angle

http://www.lowdosenaltrexone.org/index.htm#How_can_I_obtain_LDN

http://www.co-cure.org/good-doc.htm

Thanks very much TonyJ

Got my thinking...isnt Ecklonia Cava a elastase inducer, totally opposite to a elastase inhibitor?
Could someone explain?