Genetics based testing for Under/Over Methylaters

Interesting read on this important topic. The approach calls for genetic testing (gerenova) and use of targeted supps based on the identified genes. Apparently, one can have methylation problems in any of the multiple pathways (up stream , down stream) - testing can reveal the issues and a targeted supps plan can then fill in the gaps.

Seems interesting to me, I may jump and go for the genetics testing...

Methylation Cycle

Over/Under Methylation

The lab is called genova diagnostics (may be others do it as well, donno)

http://www.genovadiagnostics.com/

Methylation status could probably reveal quite of bit of useful information.

For instance, dickkopf 1 (DKK-1) is highly negative and one of the most upregulated genes in hair loss. It is upregulated in 3 to 6 hours after DHT is introduced to dermal papilla cells.

What genetically silences DKK-1? The answer is CpG islands (Hypermethylation of cytosine-rich areas)

Studies associated links between DNA methylation and gene expression. Genetic expression is usually silenced by methylation or rather are methylated, yet more active genes are not. Sequences near silent genes generally are methylated, whereas those near active regions are not.

What got my interest was the fact that we are trying to patch the problem by addressing the symptoms - if the methylation (which is so core) is broken or impacted, why not address the source of the problem vs trying to replenish individual minerals, electrolytes, hormones, amino acids, etc...

I am always intersted in figuring out the neuro transmitter interactions and how it enhances the general well being and cognitive functions. We can tinker with Serotonin, DOpamine, GABA, epipherine (Whatever it is spelled as) and so on and on by taking agonists, antagonists, blockers, etc. Whereas, if we can figure out why the body is not able to keep these NTs in balance as nature intended it to be via laerning the issues (if any) methylation cycle - we can address the core source of the problem. From Heart to Liver, to detox, to neuro transmitters - all are affected by the methylation cycle.

The science is over my head, but the overall theory resonates with me. I'd be interested in getting tested. I went to the site, but I couldn't find a total gene test -- only search by disease or symptom. What if you have no symptoms (besides hair loss) or identifiable diseases?

If I am not mistaken, genova scripts are written by providers (ND, MD, etc) - you will probably need to find a practitioner in your area, on the web site(genova) there is a link to request for finding out providers in your area.

Also, the guys doing the full testing, anslysis, and reporting is here: (scroll to the bottom, the fees is $1125...)

http://www.heartfixer.com/AMRI-Nutrigenomics.htm

There are probably other ways to skin this as well. I think the testing can be done via Genova as long as a provider can write the script for it...

I am digging into this, will post what I find.

NewReg wrote:The science is over my head, but the overall theory resonates with me. I'd be interested in getting tested. I went to the site, but I couldn't find a total gene test -- only search by disease or symptom. What if you have no symptoms (besides hair loss) or identifiable diseases?