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Vitamin A in Skin and Hair: An Update
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Vitamin A in Skin and Hair: An Update
CausticSymmetry Tue Sep 05, 2023 5:56 am
Nutrients. 2022 Jul 19;14(14):2952. doi: 10.3390/nu14142952.
Vitamin A in Skin and Hair: An Update
Christine A VanBuren 1, Helen B Everts 1
PMID: 35889909 PMCID: PMC9324272 DOI: 10.3390/nu14142952
Vitamin A is a fat-soluble micronutrient necessary for the growth of healthy skin and hair. However, both too little and too much vitamin A has deleterious effects. Retinoic acid and retinal are the main active metabolites of vitamin A. Retinoic acid dose-dependently regulates hair follicle stem cells, influencing the functioning of the hair cycle, wound healing, and melanocyte stem cells. Retinoic acid also influences melanocyte differentiation and proliferation in a dose-dependent and temporal manner. Levels of retinoids decline when exposed to ultraviolet irradiation in the skin. Retinal is necessary for the phototransduction cascade that initiates melanogenesis but the source of that retinal is currently unknown. This review discusses new research on retinoids and their effects on the skin and hair.
Keywords: hair follicle stem cells; melanocyte; melanocyte stem cells; retinoids; vitamin A.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324272/
Vitamin A in Skin and Hair: An Update
Christine A VanBuren 1, Helen B Everts 1
PMID: 35889909 PMCID: PMC9324272 DOI: 10.3390/nu14142952
Vitamin A is a fat-soluble micronutrient necessary for the growth of healthy skin and hair. However, both too little and too much vitamin A has deleterious effects. Retinoic acid and retinal are the main active metabolites of vitamin A. Retinoic acid dose-dependently regulates hair follicle stem cells, influencing the functioning of the hair cycle, wound healing, and melanocyte stem cells. Retinoic acid also influences melanocyte differentiation and proliferation in a dose-dependent and temporal manner. Levels of retinoids decline when exposed to ultraviolet irradiation in the skin. Retinal is necessary for the phototransduction cascade that initiates melanogenesis but the source of that retinal is currently unknown. This review discusses new research on retinoids and their effects on the skin and hair.
Keywords: hair follicle stem cells; melanocyte; melanocyte stem cells; retinoids; vitamin A.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324272/
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