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Experimental aftermath.
+9
imprisoned-radical
hairmaniac
SonofOdin
ManusCeles
Nuada
CausticSymmetry
shaftless
TheOne
Atlas
13 posters
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Experimental aftermath.
Insurance not covering death from medical experiment.
Payment not made for death from medical experiment is not covered,
and since the person willingly took the vx and he or she knew the risks, it can be ruled as a suicide.
https://americasfrontlinedoctors.org/videos/post/frontline-flashtm-daily-dose-vax-death-insurance-payout-denied-with-dr-peterson-pierre/
https://americasfrontlinedoctors.org/frontlineflash/
Payment not made for death from medical experiment is not covered,
and since the person willingly took the vx and he or she knew the risks, it can be ruled as a suicide.
https://americasfrontlinedoctors.org/videos/post/frontline-flashtm-daily-dose-vax-death-insurance-payout-denied-with-dr-peterson-pierre/
https://americasfrontlinedoctors.org/frontlineflash/
TheOne- Posts : 198
Join date : 2008-12-02
Age : 48
CausticSymmetry likes this post
Re: Experimental aftermath.
Examination of P..z.r Jab Under The Microscope
https://odysee.com/@drsambailey:c/nz-scientist-examines-pfizer-jab-under-the-microscope:6
Dr Sam Bailey
https://odysee.com/@drsambailey:c
https://odysee.com/@drsambailey:c/nz-scientist-examines-pfizer-jab-under-the-microscope:6
Dr Sam Bailey
https://odysee.com/@drsambailey:c
TheOne- Posts : 198
Join date : 2008-12-02
Age : 48
Re: Experimental aftermath.
I don't think the insurance companies will get away with this. Every new drug is originally considered experimental. But after going thru the various stages of testing on human subjects it either gets rejected or approved by the gov't. Vaccines were approved for safety by every gov't in the world. They no longer are considered experimental.
Ever see those drug commercials on TV? There's tons of them and they list the possible adverse side effects as well. The side effects, including possible death, sound far worse than the disease the drug was made for lol. Yet these drugs got approval for use on the general public. Would insurance companies consider dying from those drugs as possible suicide too? I don't think so.
And you cannot call death a suicide if there was no intent to die. Heck, smokers can buy life insurance, albeit at a much higher rate, but the insurance companies will still pay out if the smoker dies from his habit. It isn't considered suicide. But the insurance company can deny your claim if you lie to them by saying that you don't smoke...but secretly do.
Ever see those drug commercials on TV? There's tons of them and they list the possible adverse side effects as well. The side effects, including possible death, sound far worse than the disease the drug was made for lol. Yet these drugs got approval for use on the general public. Would insurance companies consider dying from those drugs as possible suicide too? I don't think so.
And you cannot call death a suicide if there was no intent to die. Heck, smokers can buy life insurance, albeit at a much higher rate, but the insurance companies will still pay out if the smoker dies from his habit. It isn't considered suicide. But the insurance company can deny your claim if you lie to them by saying that you don't smoke...but secretly do.
shaftless- Posts : 1414
Join date : 2012-08-12
Re: Experimental aftermath.
shaftless wrote:I don't think the insurance companies will get away with this. Every new drug is originally considered experimental. But after going thru the various stages of testing on human subjects it either gets rejected or approved by the gov't. Vaccines were approved for safety by every gov't in the world. They no longer are considered experimental.
Ever see those drug commercials on TV? There's tons of them and they list the possible adverse side effects as well. The side effects, including possible death, sound far worse than the disease the drug was made for lol. Yet these drugs got approval for use on the general public. Would insurance companies consider dying from those drugs as possible suicide too? I don't think so.
And you cannot call death a suicide if there was no intent to die. Heck, smokers can buy life insurance, albeit at a much higher rate, but the insurance companies will still pay out if the smoker dies from his habit. It isn't considered suicide. But the insurance company can deny your claim if you lie to them by saying that you don't smoke...but secretly do.
Anyone correct me if I'm wrong, from what I understand, Federal Death Administration never actually 'approved' the Quackcine, what they did was approve to extend the experiment.
Insurance companies are in the business of making money - The stats are real and actuaries have no motivation to be dishonest unlike the drug cartel, which includes the FDA, who are paid to "regulate" the people who bribe them.
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Re: Experimental aftermath.
CausticSymmetry wrote:
Anyone correct me if I'm wrong, from what I understand, Federal Death Administration never actually 'approved' the Quackcine, what they did was approve to extend the experiment.
Insurance companies are in the business of making money - The stats are real and actuaries have no motivation to be dishonest unlike the drug cartel, which includes the FDA, who are paid to "regulate" the people who bribe them.
Quackcine was initially given emergency use authorization then officialy approved 6 or 8 months later.
While under emergency use authorization, goverment has immunity from liability.
TheOne- Posts : 198
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Re: Experimental aftermath.
Dr. John Campbell going over Pfizer documents.
https://www.youtube.com/watch?v=7YOD9drZasM
At least one mainstream media covering this. 'study on mRNA Covid vaccine side effects'
https://www.youtube.com/watch?v=bJe5l4SGi8g
wouldn`t be surprised if these get taken down.
TheOne- Posts : 198
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Age : 48
CausticSymmetry likes this post
Re: Experimental aftermath.
15 players unable to finish.
https://au.sports.yahoo.com/tennis-2022-viewers-shocked-bizarre-miami-open-carnage-004007552.html
https://truth11.com/2022/04/03/whats-going-on-tennis-world-stunned-after-miami-open-carnage-15-fully-vaccinated-players-unable-to-finish/
https://au.sports.yahoo.com/tennis-2022-viewers-shocked-bizarre-miami-open-carnage-004007552.html
https://truth11.com/2022/04/03/whats-going-on-tennis-world-stunned-after-miami-open-carnage-15-fully-vaccinated-players-unable-to-finish/
TheOne- Posts : 198
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CausticSymmetry likes this post
Re: Experimental aftermath.
Weird. One guy had foot blisters tho. I tried to find out what each player's excuse was but all they said was that they felt unwell. But nobody cares for tennis. It would be way more newsworthy if a lot of hockey, football and basketball players couldn't finish the game due to chest pains or whatever. Which hasn't happened yet even tho those games are a lot more physical and energetic...which you'd think would trigger heart irregularities more easily than tennis.
shaftless- Posts : 1414
Join date : 2012-08-12
Re: Experimental aftermath.
shaftless wrote:Weird. One guy had foot blisters tho. I tried to find out what each player's excuse was but all they said was that they felt unwell. But nobody cares for tennis. It would be way more newsworthy if a lot of hockey, football and basketball players couldn't finish the game due to chest pains or whatever. Which hasn't happened yet even tho those games are a lot more physical and energetic...which you'd think would trigger heart irregularities more easily than tennis.
https://www.bitchute.com/video/c22c3KGI0cLl/
https://www.bitchute.com/video/ssevYsmvuRSr/
https://www.bitchute.com/video/5fRVYQ01UNZM/
https://www.bitchute.com/video/sqTd8LtViqI0/
https://www.bitchute.com/video/SvbBNutA2MH1/
https://www.bitchute.com/video/e5ZwkRP2mwa6/
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TheOne likes this post
Re: Experimental aftermath.
Great post CS, what gets me is how some people don`t want to hear it,
or even get upset at the mere mention of the vx is s***.
This includes my sister who is a Doctor, does not even want to look at the official pfizer data and how bad it is.
Just replies with its fake news.
or even get upset at the mere mention of the vx is s***.
This includes my sister who is a Doctor, does not even want to look at the official pfizer data and how bad it is.
Just replies with its fake news.
TheOne- Posts : 198
Join date : 2008-12-02
Age : 48
CausticSymmetry likes this post
Re: Experimental aftermath.
TheOne wrote:Great post CS, what gets me is how some people don`t want to hear it,
or even get upset at the mere mention of the vx is s***.
This includes my sister who is a Doctor, does not even want to look at the official Pfizer data and how bad it is.
Just replies with its fake news.
Some facts I try to impress upon anyone willing to think outside of the mass conditioning we all get saturated with:
The FDA's real purpose is to protect patent holders. FDA does not independently perform any research no, instead they rely completely on the drug manufacturers they are suppose to regulate to provide them "proof" their drug is 'safe.'
In separate places, when hospital strikes occurred, the death rates plummeted significantly.
Sick care is so dangerous, that people do better when hospital access is limited.
https://www.sciencedirect.com/science/article/abs/pii/S0277953608005066
"Medical error" 3rd leading cause of death
https://pubmed.ncbi.nlm.nih.gov/27143499/
Editor Of Top Medical Journal Admits ‘50% Of Pro-Vaccine Science Is Fraudulent’
Dr. Richard Horton, the current editor-in-chief of the Lancet – considered to be one of the most well respected peer-reviewed medical journals in the world – has admitted that at least half of the medical literature used to justify the vaccination agenda is “fraudulent” and that “science has taken a turn towards Darkness.“
Dr. Horton recently published a statement declaring that a lot of published research supposedly pushing the vaccine agenda is in fact unreliable at best, if not completely fraudulent.
https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736%2815%2960696-1.pdf
Data fraud in clinical trials
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340084/
What actual training do medical doctors receive about va$$cines?
None, except for the mantra of 'they've saved the world against X, X and X' without a shred of proof and to
follow the Centers for Disease Creation's sickness generating cocktail schedule without question.
It's really easy to identify a Quackine injury, but none of them receive any training on how to identify them.
Last, but not least, there are some places in the world, totally free of governments, drugs, doctors, dentists, Quackcines. These people are the pinnacle of health - zero disease, perfect teeth, and poison free. These mostly
unheard of cultures are like a perfect control group, that reveals what happens if all of these control measures disappear.
Then there are people who want to expand on the idealist youth who are totally inebriated by propaganda.
Klaus Schwab probably understands that it's easier to mold and shape young people into positions of installed power.
https://www.youtube.com/watch?v=OwQ3fW0dgNo
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TheOne and bobbers2011 like this post
Re: Experimental aftermath.
Here's something interesting. A british columbia canadian doctor speaks out....
https://rumble.com/vz0j6f-doctors-warning.html?fbclid=IwAR0TLusUmQu45mY_abbbgmLByqe_hI4w85zzxRmtF_4pKMCZLnvsy1vv5UQ
Is the spike protein produced by the vaccines toxic? Some say yes. Some say no. But there are studies that show that the vaccine can enter liver cells where the reverse transcriptase enzyme could change our DNA by altering the vaccine's mRNA back into DNA and incorporating it into our genome...or something like that.
Kinda complicated for us regular joes, but there does seem to be a lot of unknowns.
https://rumble.com/vz0j6f-doctors-warning.html?fbclid=IwAR0TLusUmQu45mY_abbbgmLByqe_hI4w85zzxRmtF_4pKMCZLnvsy1vv5UQ
Is the spike protein produced by the vaccines toxic? Some say yes. Some say no. But there are studies that show that the vaccine can enter liver cells where the reverse transcriptase enzyme could change our DNA by altering the vaccine's mRNA back into DNA and incorporating it into our genome...or something like that.
Kinda complicated for us regular joes, but there does seem to be a lot of unknowns.
shaftless- Posts : 1414
Join date : 2012-08-12
CausticSymmetry likes this post
Re: Experimental aftermath.
Dr Lawrence Palevsky goes over the whole thing in layman's terms.
https://odysee.com/@DrLawrencePalevsky:f/dr.palevsky-what-is-spike-protein-amp-effects-on-kids-amp-women:8
https://odysee.com/@DrLawrencePalevsky:f
https://odysee.com/@DrLawrencePalevsky:f/dr.palevsky-what-is-spike-protein-amp-effects-on-kids-amp-women:8
https://odysee.com/@DrLawrencePalevsky:f
TheOne- Posts : 198
Join date : 2008-12-02
Age : 48
Re: Experimental aftermath.
So he says that the body doesn't shut off the spike protein producing mechanism of the vaccines and it could go on indefinitely. Wouldn't they see that in their animal experiments that they did first before they tested it on people?
Also the manufactured spike proteins from the vaccines supposedly does not behave in the same way that the viral spike proteins do. The vax ones are supposed to be safer...which makes some sense since these are "synthetic" spike proteins and not naturally-occurring ones. But then I wonder how true that is when they rushed out these vaccines. Some side effects take a long time to show up.
And lastly, but not leastly... this palevsky guy speaks way too slow for me. I'm glad he's not also a grinner like that zealie lady doc lol
Also the manufactured spike proteins from the vaccines supposedly does not behave in the same way that the viral spike proteins do. The vax ones are supposed to be safer...which makes some sense since these are "synthetic" spike proteins and not naturally-occurring ones. But then I wonder how true that is when they rushed out these vaccines. Some side effects take a long time to show up.
And lastly, but not leastly... this palevsky guy speaks way too slow for me. I'm glad he's not also a grinner like that zealie lady doc lol
shaftless- Posts : 1414
Join date : 2012-08-12
Re: Experimental aftermath.
I'm a spike protein skeptic. But I heard something today that I haven't heard before.
Will post on on whatever follows up on this very brief idea.
https://www.bitchute.com/video/rWqE7Dj3iXrK/
Will post on on whatever follows up on this very brief idea.
https://www.bitchute.com/video/rWqE7Dj3iXrK/
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Re: Experimental aftermath.
DR. BRIAN ARDIS - THERE IS NO VIRUS - ITS INTENTIONAL POISONING - IN YOUR CITY WATER SUPPLY
https://www.bitchute.com/video/nIFprMa9tPqM/
Premier Documentary - Watch the Water
https://www.bitchute.com/video/TA9VK52lDCN7/
https://www.bitchute.com/video/nIFprMa9tPqM/
Premier Documentary - Watch the Water
https://www.bitchute.com/video/TA9VK52lDCN7/
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Re: Experimental aftermath.
Bing Liu was apparently killed by his jilted lover in a murder suicide....or is that what they want you to believe? It be interesting to hear more of this snake venom in our water supply theory. But I guess everyone is wondering how could it be concentrated enuff to do any damage? Drinking straight venom doesn't always kill you since digestive enzymes break it down in our stomach...but if it gets past that point it could be absorbed into the blood and cause a lot of trouble depending on what snake it came from. Some venoms are pretty potent. But you'd need TONS of it floating around in the tall water towers in all the towns and cities.
Unless...it's a synthetic venom-based poison that is waaaaaay stronger the natural kind. But wouldn't that maybe change the pH of tap water and maybe also the smell or taste of it? There's nothing easier than to have tap water analyzed in a private lab.
And yes there's lots of info on google about snakes possibly transmitting the virus in china. No different than being bitten by an infected bat. The current theory is that a bat (or snake) bit a pangolin and then transferred it to people. Pangolins are the most illegally traded animal in china...and the whole world for that matter...and are prized for their supposed health benefits and eating delicacy. A wet market would be an ideal place to secretly covet one and that's probably just what happened in wuhan.
Unless...it's a synthetic venom-based poison that is waaaaaay stronger the natural kind. But wouldn't that maybe change the pH of tap water and maybe also the smell or taste of it? There's nothing easier than to have tap water analyzed in a private lab.
And yes there's lots of info on google about snakes possibly transmitting the virus in china. No different than being bitten by an infected bat. The current theory is that a bat (or snake) bit a pangolin and then transferred it to people. Pangolins are the most illegally traded animal in china...and the whole world for that matter...and are prized for their supposed health benefits and eating delicacy. A wet market would be an ideal place to secretly covet one and that's probably just what happened in wuhan.
shaftless- Posts : 1414
Join date : 2012-08-12
Re: Experimental aftermath.
I suggest you watch the full version, because the question about the how "they do it" is answered.
It would be synthesized, also in the long version, it mentions other avenues.
https://www.bitchute.com/video/TA9VK52lDCN7/
It would be synthesized, also in the long version, it mentions other avenues.
https://www.bitchute.com/video/TA9VK52lDCN7/
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TheOne likes this post
Re: Experimental aftermath.
Boy, for a retired chiropractor he sure has a lot of ideas...but I don't think they are all that well backed up by science.
He talks about monoclonal antibodies being banned for covid treatment. Not all monoclonal antibodies are stopped from being a covid treatment. There's one called bebtelovimab that is only given to covid patients that are mild to moderately affected and have a greater risk of getting worse. It was stopped for patients that were already on oxygen support becuz it seemed to worsen their condition.
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-new-monoclonal-antibody-treatment-covid-19-retains
He says that bats were hibernating when covid broke in china so it couldn't have come from them. Depending on the species and temperate zones bats do fly around in winter for various reasons....
https://jecoenv.biomedcentral.com/articles/10.1186/s41610-018-0097-9
And what's he talking about at the 23:32 mark when he says that the genetic sequencing of antibodies (antibodies?) from sick people resembled snake dna instead of bat dna? First of all they're not looking for any kind of animal dna in the sick people...they are looking for viral dna. So why would he say that they should have found bat dna but instead found snake dna? They shouldn't be expecting to find any dna resembling wild animals at all...just known viral gene sequences. He probably misunderstood things.
He mentions city wastewater containing covid dna being used to predict where the next outbreak will be is backwards. When they find it in wastewater that means a lot of people already had it...not the next outbreak...and it does sound logical. But what he doesn't say is that there's a difference between the covid dna found in poop compared the dna found that's in mucous membranes in your nose or throat or lungs. Here's an explanation....
"The virus appears in faeces within three days of infection, which is much sooner than the time taken for people to develop symptoms severe enough for them to be hospitalized. It can take up to two weeks from the time someone is infected to the time they receive a diagnosis."
So detection of poop viral dna is an early-warning system that will show where many people will ultimately come down with obvious symptoms a week or so later. Not that hard to understand really.
So exactly how is this synthetic snake venom being introduced into our water supply? And at what concentration to be effective? Town and city water towers are huge and hold millions of gallons of water. He didn't actually elaborate on that. Only saying that water contractors are involved. Evil water contractors that are in cahoots with the cdc? How did they muscle in and take over the regular water contractors that were already contracted there for years? Sneaking in enormous amounts of synthetic snake venom into the water supply without being noticed is a tricky adventure.
And why are children "basically immune" to covid like stew himself said at the beginning of the video at the 4:30 mark. Don't children drink the same water grownups do? Don't they have nicotinic receptors in their brains where the snake venom can do its damage? They certainly don't smoke.... which is a peculiarity they found that smokers basically avoided covid early on in the pandemic like dr ardis mentioned. Yet children seem to avoid this snake venom in our water.
Sigh....I have to go. Ol' lucy (lucifer) needs some help on another message board.
*puts on "sympathy for the devil" by the stones* lol
He talks about monoclonal antibodies being banned for covid treatment. Not all monoclonal antibodies are stopped from being a covid treatment. There's one called bebtelovimab that is only given to covid patients that are mild to moderately affected and have a greater risk of getting worse. It was stopped for patients that were already on oxygen support becuz it seemed to worsen their condition.
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-new-monoclonal-antibody-treatment-covid-19-retains
He says that bats were hibernating when covid broke in china so it couldn't have come from them. Depending on the species and temperate zones bats do fly around in winter for various reasons....
https://jecoenv.biomedcentral.com/articles/10.1186/s41610-018-0097-9
And what's he talking about at the 23:32 mark when he says that the genetic sequencing of antibodies (antibodies?) from sick people resembled snake dna instead of bat dna? First of all they're not looking for any kind of animal dna in the sick people...they are looking for viral dna. So why would he say that they should have found bat dna but instead found snake dna? They shouldn't be expecting to find any dna resembling wild animals at all...just known viral gene sequences. He probably misunderstood things.
He mentions city wastewater containing covid dna being used to predict where the next outbreak will be is backwards. When they find it in wastewater that means a lot of people already had it...not the next outbreak...and it does sound logical. But what he doesn't say is that there's a difference between the covid dna found in poop compared the dna found that's in mucous membranes in your nose or throat or lungs. Here's an explanation....
"The virus appears in faeces within three days of infection, which is much sooner than the time taken for people to develop symptoms severe enough for them to be hospitalized. It can take up to two weeks from the time someone is infected to the time they receive a diagnosis."
So detection of poop viral dna is an early-warning system that will show where many people will ultimately come down with obvious symptoms a week or so later. Not that hard to understand really.
So exactly how is this synthetic snake venom being introduced into our water supply? And at what concentration to be effective? Town and city water towers are huge and hold millions of gallons of water. He didn't actually elaborate on that. Only saying that water contractors are involved. Evil water contractors that are in cahoots with the cdc? How did they muscle in and take over the regular water contractors that were already contracted there for years? Sneaking in enormous amounts of synthetic snake venom into the water supply without being noticed is a tricky adventure.
And why are children "basically immune" to covid like stew himself said at the beginning of the video at the 4:30 mark. Don't children drink the same water grownups do? Don't they have nicotinic receptors in their brains where the snake venom can do its damage? They certainly don't smoke.... which is a peculiarity they found that smokers basically avoided covid early on in the pandemic like dr ardis mentioned. Yet children seem to avoid this snake venom in our water.
Sigh....I have to go. Ol' lucy (lucifer) needs some help on another message board.
*puts on "sympathy for the devil" by the stones* lol
shaftless- Posts : 1414
Join date : 2012-08-12
Re: Experimental aftermath.
I think he made a compelling argument. Trusting the CDC on the other hand, which are known medical terrorists and who have a financial interest in Quackines.
STN~WORLD PREMIERE: WATCH THE WATER FULL MOVIE
https://www.bitchute.com/video/ygl2FP6FpkMh/
STN~WORLD PREMIERE: WATCH THE WATER FULL MOVIE
https://www.bitchute.com/video/ygl2FP6FpkMh/
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TheOne likes this post
Re: Experimental aftermath.
Some research of my own:
Proteolytic trypsin-like enzymes, which are catalyzed by metals (e.g., calcium, magnesium, and zinc), are common constituents of pit viper venom and cause marked tissue destruction. Arginine ester hydrolase is a bradykinin-releasing agent that may adversely affect clotting activity.
https://www.unco.edu/nhs/biology/about-us/mackessy-stephen/documents/2010-Toxins-and-Hemostasis-Ch-30-Mackessy.pdf
Interesting to note that in order for researchers to create from "thin air" alleged spike proteins from a non-existent virus, they add trypsin enzymes to a cell culture.
Proteolytic trypsin-like enzymes, which are catalyzed by metals (e.g., calcium, magnesium, and zinc), are common constituents of pit viper venom and cause marked tissue destruction. Arginine ester hydrolase is a bradykinin-releasing agent that may adversely affect clotting activity.
https://www.unco.edu/nhs/biology/about-us/mackessy-stephen/documents/2010-Toxins-and-Hemostasis-Ch-30-Mackessy.pdf
Interesting to note that in order for researchers to create from "thin air" alleged spike proteins from a non-existent virus, they add trypsin enzymes to a cell culture.
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Re: Experimental aftermath.
It's strange that our bodies already have a natural snake venom-like enzyme that was mentioned in the first dr ardis video. Covid seems to greatly express this enzyme in some patients which causes a lot of damage to tissue. A virus that duplicates itself over and over in our bodies and causes this enzyme to explode and hurt us would seem to be a more effective way of sinister intent than to somehow sneak enuff of a foreign poison into a huge water supply system.
I'm wondering if the mass creation of spike proteins from the vaccines might somehow trigger our snake venom enzyme to go wacky as well.
I'm wondering if the mass creation of spike proteins from the vaccines might somehow trigger our snake venom enzyme to go wacky as well.
shaftless- Posts : 1414
Join date : 2012-08-12
Re: Experimental aftermath.
shaftless wrote:It's strange that our bodies already have a natural snake venom-like enzyme that was mentioned in the first dr ardis video. Covid seems to greatly express this enzyme in some patients which causes a lot of damage to tissue. A virus that duplicates itself over and over in our bodies and causes this enzyme to explode and hurt us would seem to be a more effective way of sinister intent than to somehow sneak enuff of a foreign poison into a huge water supply system.
I'm wondering if the mass creation of spike proteins from the vaccines might somehow trigger our snake venom enzyme to go wacky as well.
After all failure of any researchers to proof isolation/purification of an infectious virus or any virus to exist, do you still believe it's a virus and not something toxic?
The original definition of a virus is snake venom.
_________________
My regimen
http://www.immortalhair.org/mpb-regimen
(Primary site under construction: )
Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
Primary site under construction:
https://immortalhair.org/
Archived as of 2022 here:
https://web.archive.org/web/20220330061828/https://www.immortalhair.org/
Re: Experimental aftermath.
In the past here, when we were talking about hair loss and not so much fake viruses and organized killing sprees and genocidal maniacs.
There are things like Ecklonia cava which inhibit PLA2 or phospholipase A2 enzymes.
Marine algae have attracted increasing attention as a potential resource for cosmeceutical
ingredients [34,45]. E. cava is a rich source of phlorotannins, a unique group of polyphenol compounds
found in marine brown algae [25,46]. The total phenolic content of E. cava extract was estimated to
be the highest of the 50 marine plants tested in our previous study [33]. In the present study, of the
50 marine alga extracts tested, E. cava extract was the most protective against PM10 toxicity in HaCaT
keratinocytes. E. cava extract attenuated PGE2 production in cells exposed to varying concentrations of
PM10 more eectively than NAC, a positive control antioxidant. Dieckol purified from E. cava extract
also exhibited inhibitory activity against PM10-induced PGE2 production.
The synthesis of PGE2 begins with the production of arachidonic acid from membrane
phospholipids by the enzymatic action of phospholipase A2, followed by the conversion of arachidonic
acid to PGG2 and then to PGH2 by reactions catalyzed by COX-1 and COX-2 [42]. Both isoforms are
present in many normal human tissues, and both isoforms are upregulated in a variety of pathological
conditions [47]. PGE2 synthesis from PGH2 is catalyzed by mPGES-1, mPGES-2, and cPGES [48].
Of these isoforms, mPGES-1 is considered responsible for the increased PGE2 synthesis during
inflammation [49].
Previous studies have shown that dieckol and phlorotannins–rich brown alga extracts attenuated
PGE2 production and COX-2 expression in lipopolysaccharide (LPS)-stimulated RAW264.7 murine
macrophage cells [43], in LPS-stimulated murine BV2 microglia [50], and in UVB radiation-induced
skin carcinogenesis in SKH-1 mice [51]. In the present study, PM10 increased the gene expression
of both COX-1 and COX-2 in keratinocytes, and these PM-induced COX-1 and COX-2 expressions
were ameliorated by E. cava extract and dieckol, as well as by NAC (positive control antioxidant).
In addition, PM10 increased the expression of mPGES-1 and mPGES-2, and PM10-induced mPGES-2
expression was reduced by E. cava extract. Dieckol attenuated the expression of mPGES-1 stimulated by
PM10. This suggests that the E. cava extract and dieckol can alleviate PM10-induced PGE2 production,
at least partially, through the inhibition of COX-1, COX-2, mPGES-1, and/or mPGES-2 gene expression(Figure 10). The present study showed that dieckol alleviated the PM-induced inflammatory responses
of keratinocytes and PM-induced morphological changes in a 3D-reconstructed skin model.
Marine algae have attracted increasing attention as a potential resource for cosmeceutical
ingredients [34,45]. E. cava is a rich source of phlorotannins, a unique group of polyphenol compounds
found in marine brown algae [25,46]. The total phenolic content of E. cava extract was estimated to
be the highest of the 50 marine plants tested in our previous study [33]. In the present study, of the
50 marine alga extracts tested, E. cava extract was the most protective against PM10 toxicity in HaCaT
keratinocytes.
E. cava extract attenuated PGE2 production in cells exposed to varying concentrations of
PM10 more eectively than NAC, a positive control antioxidant. Dieckol purified from E. cava extract
also exhibited inhibitory activity against PM10-induced PGE2 production.
The synthesis of PGE2 begins with the production of arachidonic acid from membrane
phospholipids by the enzymatic action of phospholipase A2, followed by the conversion of arachidonic
acid to PGG2 and then to PGH2 by reactions catalyzed by COX-1 and COX-2 [42]. Both isoforms are
present in many normal human tissues, and both isoforms are upregulated in a variety of pathological
conditions.
There are things like Ecklonia cava which inhibit PLA2 or phospholipase A2 enzymes.
Marine algae have attracted increasing attention as a potential resource for cosmeceutical
ingredients [34,45]. E. cava is a rich source of phlorotannins, a unique group of polyphenol compounds
found in marine brown algae [25,46]. The total phenolic content of E. cava extract was estimated to
be the highest of the 50 marine plants tested in our previous study [33]. In the present study, of the
50 marine alga extracts tested, E. cava extract was the most protective against PM10 toxicity in HaCaT
keratinocytes. E. cava extract attenuated PGE2 production in cells exposed to varying concentrations of
PM10 more eectively than NAC, a positive control antioxidant. Dieckol purified from E. cava extract
also exhibited inhibitory activity against PM10-induced PGE2 production.
The synthesis of PGE2 begins with the production of arachidonic acid from membrane
phospholipids by the enzymatic action of phospholipase A2, followed by the conversion of arachidonic
acid to PGG2 and then to PGH2 by reactions catalyzed by COX-1 and COX-2 [42]. Both isoforms are
present in many normal human tissues, and both isoforms are upregulated in a variety of pathological
conditions [47]. PGE2 synthesis from PGH2 is catalyzed by mPGES-1, mPGES-2, and cPGES [48].
Of these isoforms, mPGES-1 is considered responsible for the increased PGE2 synthesis during
inflammation [49].
Previous studies have shown that dieckol and phlorotannins–rich brown alga extracts attenuated
PGE2 production and COX-2 expression in lipopolysaccharide (LPS)-stimulated RAW264.7 murine
macrophage cells [43], in LPS-stimulated murine BV2 microglia [50], and in UVB radiation-induced
skin carcinogenesis in SKH-1 mice [51]. In the present study, PM10 increased the gene expression
of both COX-1 and COX-2 in keratinocytes, and these PM-induced COX-1 and COX-2 expressions
were ameliorated by E. cava extract and dieckol, as well as by NAC (positive control antioxidant).
In addition, PM10 increased the expression of mPGES-1 and mPGES-2, and PM10-induced mPGES-2
expression was reduced by E. cava extract. Dieckol attenuated the expression of mPGES-1 stimulated by
PM10. This suggests that the E. cava extract and dieckol can alleviate PM10-induced PGE2 production,
at least partially, through the inhibition of COX-1, COX-2, mPGES-1, and/or mPGES-2 gene expression(Figure 10). The present study showed that dieckol alleviated the PM-induced inflammatory responses
of keratinocytes and PM-induced morphological changes in a 3D-reconstructed skin model.
Marine algae have attracted increasing attention as a potential resource for cosmeceutical
ingredients [34,45]. E. cava is a rich source of phlorotannins, a unique group of polyphenol compounds
found in marine brown algae [25,46]. The total phenolic content of E. cava extract was estimated to
be the highest of the 50 marine plants tested in our previous study [33]. In the present study, of the
50 marine alga extracts tested, E. cava extract was the most protective against PM10 toxicity in HaCaT
keratinocytes.
E. cava extract attenuated PGE2 production in cells exposed to varying concentrations of
PM10 more eectively than NAC, a positive control antioxidant. Dieckol purified from E. cava extract
also exhibited inhibitory activity against PM10-induced PGE2 production.
The synthesis of PGE2 begins with the production of arachidonic acid from membrane
phospholipids by the enzymatic action of phospholipase A2, followed by the conversion of arachidonic
acid to PGG2 and then to PGH2 by reactions catalyzed by COX-1 and COX-2 [42]. Both isoforms are
present in many normal human tissues, and both isoforms are upregulated in a variety of pathological
conditions.
_________________
My regimen
http://www.immortalhair.org/mpb-regimen
(Primary site under construction: )
Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
Primary site under construction:
https://immortalhair.org/
Archived as of 2022 here:
https://web.archive.org/web/20220330061828/https://www.immortalhair.org/
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