Bombshell of an overview of hairloss

From Raya Khanin on LinkedIn

Publication: https://www.mdpi.com/2079-9284/10/4/106

#hairloss #cosmeceuticals #review

New review synthesizes research from the past decade to present an updated understanding of hair loss and its etiology, focusing on #hair #rejuvenation using cosmeceuticals.

The key components contributing to hair loss, referred to as the 'big eight strikes'
1. Imbalance of androgens (DHT, #testosterone, and SHBG) in cases of androgenetic alopecia: DHT triggers TGF-β1 expression, affecting the canonical Wnt signaling pathway.
2. Imbalance of prostaglandins (PGF2-α, PGD2): Depletion of NADPH redirects prostaglandin biosynthesis towards PGD2, influenced by #bacterial overgrowth of P. acnes and the polyol pathway.
3. Overactive #sebum production and sugar metabolism: Prostaglandins and the polyol pathway alter sugar metabolism, favoring lipid production over glycogen stores. This may be due to increased expression of AKR1B1 and reduced insulin-like growth factor 1 expression in the balding scalp.
4. Bacterial and #fungal overgrowth: Hair loss-affected scalps often have bacterial overgrowth or #inflammatory infiltrates as byproducts of clearing microbes. P. acnes or S. aureus (in scarring alopecia) bacteria and M. furfur fungus are common culprits.
5. Micro-inflammation: subtle #Inflammation in the balding scalp can range from severe (scarring alopecia) to low-grade chronic (androgenetic alopecia).
6. Micro-#scarring and #collagen : Fibrosis progression can be halted but not easily reversed. Biomimetic peptides signal dermis restructuring and promote #stemcell niche restoration as a potential approach.
7. Inefficient #circulation and #metabolism (e.g., #cholesterol and scalp tension): Circulation is vital for nutrient transportation and waste removal. Inactivity of metabolizing enzymes responsible for converting waste into soluble forms, like cholesterol metabolism, can hinder waste elimination.
8. #Nutrient deficiency (or nutrient synthesis via metabolism, e.g., #vitaminD): Nutrient deficiencies can be addressed through #supplementation, and supplementing items even in the absence of deficiencies (e.g., #aminoacids ) can benefit. Local metabolic processes can lead to deficiencies of nutrients like vitamin D despite adequate dietary intake.

Commercial cosmeceutical hair serums targeting these factors may improve #hairhealth by utilizing #bioactive #peptides and #plant compounds such as #flavonoids (isoflavones, procyanidins, flavanols, and flavonols) or sterols/triterpenes.

Cosmeceuticals targeting all eight of these factors are expected to be more effective than those addressing only a few. However, it's rare to find hair #rejuvenating #serums that address all eight factors in the market.

Many #therapeutic interventions are applicable to various types of hair loss. The review concludes with suggestions for improving #scalp and #hairhealth through a cosmeceutical approach.

#hairlosssolution #hairgrowth #microbiome #beautybiotech #beautyfromwithin