Search
Check Out Our Sponsors
Latest topics
The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice.
2 posters
Page 1 of 1
The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice.
Ann N Y Acad Sci. 2016 Jan;1363:80-90. doi: 10.1111/nyas.12967. Epub 2015 Nov 24.
The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice.
Kruger WD1, Gupta S1.
Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Cystathionine β synthase (CBS) is a key enzyme in the methionine and cysteine metabolic pathway, acting as a metabolic gatekeeper to regulate the flow of fixed sulfur from methionine to cysteine. Mutations in the CBS gene cause clinical CBS deficiency, a disease characterized by elevated plasma total homocysteine (tHcy) and methionine and decreased plasma cysteine. The treatment goal for CBS-deficient patients is to normalize the metabolic values of these three metabolites using a combination of vitamin therapy and dietary manipulation. To better understand the effectiveness of nutritional treatment strategies, we have performed a series of long-term dietary manipulation studies using our previously developed Tg-I278T Cbs(-/-) mouse model of CBS deficiency and sibling Tg-I278T Cbs(+/-) controls. Tg-I278T Cbs(-/-) mice have undetectable levels of CBS activity, extremely elevated plasma tHcy, modestly elevated plasma methionine, and low plasma cysteine. They exhibit several easily assayable phenotypes, including osteoporosis, loss of fat mass, reduced life span, and facial alopecia. The diets used in these studies differed in the amounts of sulfur amino acids or sulfur amino acid precursors. In this review, we will discuss our findings and their relevance to CBS deficiency and the concept of gene-diet interaction.
Full Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801721/
The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice.
Kruger WD1, Gupta S1.
Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Cystathionine β synthase (CBS) is a key enzyme in the methionine and cysteine metabolic pathway, acting as a metabolic gatekeeper to regulate the flow of fixed sulfur from methionine to cysteine. Mutations in the CBS gene cause clinical CBS deficiency, a disease characterized by elevated plasma total homocysteine (tHcy) and methionine and decreased plasma cysteine. The treatment goal for CBS-deficient patients is to normalize the metabolic values of these three metabolites using a combination of vitamin therapy and dietary manipulation. To better understand the effectiveness of nutritional treatment strategies, we have performed a series of long-term dietary manipulation studies using our previously developed Tg-I278T Cbs(-/-) mouse model of CBS deficiency and sibling Tg-I278T Cbs(+/-) controls. Tg-I278T Cbs(-/-) mice have undetectable levels of CBS activity, extremely elevated plasma tHcy, modestly elevated plasma methionine, and low plasma cysteine. They exhibit several easily assayable phenotypes, including osteoporosis, loss of fat mass, reduced life span, and facial alopecia. The diets used in these studies differed in the amounts of sulfur amino acids or sulfur amino acid precursors. In this review, we will discuss our findings and their relevance to CBS deficiency and the concept of gene-diet interaction.
Full Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801721/
_________________
My regimen
http://www.immortalhair.org/mpb-regimen
Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
Re: The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice.
TLDR; Supplement NAC alongside ALA+ALCAR?
NYJets- Posts : 486
Join date : 2012-05-17
Re: The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice.
NYJets wrote:TLDR; Supplement NAC alongside ALA+ALCAR?
Not exactly, no.
Would take the time to read the full study.
_________________
My regimen
http://www.immortalhair.org/mpb-regimen
Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
Similar topics
» amino acids
» AjiPure Amino Acids
» Amino Acids and Growth Hormone
» Food sources of Lysine and other amino acids?
» Do vegetarians/vegans need to supplements amino acids
» AjiPure Amino Acids
» Amino Acids and Growth Hormone
» Food sources of Lysine and other amino acids?
» Do vegetarians/vegans need to supplements amino acids
Page 1 of 1
Permissions in this forum:
You cannot reply to topics in this forum
|
|
Yesterday at 4:00 pm by CausticSymmetry
» *The first scientific evidence in 2021 that viruses do not exist*
Fri Apr 26, 2024 12:44 pm by CausticSymmetry
» Potential Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells
Wed Apr 17, 2024 7:44 am by CausticSymmetry
» Breast Biopsy
Sun Apr 14, 2024 2:23 am by shaftless
» Sorry if brought up before but: Best topical to help aid in breaking up fibrosis?
Sat Apr 13, 2024 2:51 am by Hoppipolla
» solar eclipse on april 8
Thu Apr 11, 2024 4:04 am by shaftless
» Role and Mechanisms of Phytochemicals in Hair Growth and Health
Wed Apr 10, 2024 4:20 am by CausticSymmetry
» IH Regimen
Tue Apr 09, 2024 4:25 pm by CF
» Exosome Theory and Herpes
Mon Apr 08, 2024 11:16 am by MikeGore