Azoles (Keto/mico)

Nizoral:

Topical application of ketoconazole (Nizoral) stimulates hair growth in C3H/HeN mice.

J Dermatol. 2005 Apr;32(4):243-7.
Jiang J, Tsuboi R, Kojima Y, Ogawa H.
Department of Dermatology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.

Because this study was in mice and not balding men, it shows that Ketoconazole (Nizoral) has a hair growth stimulant effect separate from its ability to block the actions of male hormones.

Ketoconazole (KCZ) is an imidazole anti-fungal agent that is also effective in topical applications for treating seborrheic dermatitis and dandruff. Recently, topical use of 2% KCZ shampoo has been reported to have had a clinically therapeutic effect on androgenetic alopecia. The present study was conducted with the purpose of quantitatively examining the stimulatory effect of KCZ on hair growth in a mouse model. Coat hairs on the dorsal skin of seven week-old male C3H/HeN mice were gently clipped, and either 2% KCZ solution in 95% ethanol or a vehicle solution was topically applied once daily for three weeks. The clipped area was photographed, and the ratio of re-grown coat area was then calculated. The results demonstrated that 2% KCZ had a macroscopically significant stimulatory effect compared with the vehicle group (p<0.01, n=10). Repeated experiments showed similar effects, confirming the efficacy of KCZ as a hair growth stimulant. Although the therapeutic mechanism of topical KCZ for hair growth is unclear, our results suggest that topical applications of the substance are useful for treating seborrheic dermatitis accompanied by hair regression or male pattern hairloss

Miconazole+KCZ:

Hairloss Study Abstract: Hydroxylation of 5 alpha-androstane-3 beta,17 beta-diol by rat prostate microsomes: potent inhibition by imidazole-type antimycotic drugs and lack of inhibition by steroid 5 alpha-reductase inhibitors.

Title
Hydroxylation of 5 alpha-androstane-3 beta,17 beta-diol by rat prostate microsomes: potent inhibition by imidazole-type antimycotic drugs and lack of inhibition by steroid 5 alpha-reductase inhibitors.
Author
Gemzik B, Parkinson A
Address
Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City 66160-7417.
Source
Arch Biochem Biophys, 296: 2, 1992 Aug 1, 366-73
Abstract
5 alpha-Dihydrotestosterone, the principal androgen mediating prostate growth and function in the rat, is formed from testosterone by steroid 5 alpha-reductase. The inactivation of 5 alpha-dihydrotestosterone involves reversible reduction to 5 alpha-androstane-3 beta,17 beta-diol by 3 beta-hydroxysteroid oxidoreductase followed by 6 alpha-, 7 alpha-, or 7 beta-hydroxylation. 5 alpha-Androstane-3 beta,17 beta-diol hydroxylation represents the ultimate inactivation step of dihydrotestosterone in rat prostate and is apparently catalyzed by a single, high-affinity (Km approximately 0.5 microM) microsomal cytochrome P450 enzyme. The present studies were designed to determine if 5 alpha-androstane-3 beta,17 beta-diol hydroxylation by rat prostate microsomes is inhibited by agents that are known inhibitors of androgen-metabolizing enzymes. Inhibitors of steroid 5 alpha-reductase (4-azasteroid analogs; 10 microM) or inhibitors of 3 beta-hydroxysteroid oxidoreductase (trilostane, azastene, and cyanoketone; 10 microM) had no appreciable effect on the 6 alpha-, 7 alpha-, or 7 beta-hydroxylation of 5 alpha-androstane-3 beta,17 beta-diol (10 microM) by rat prostate microsomes. Imidazole-type antimycotic drugs (ketoconazole, clotrimazole, and miconazole; 0.1-10 microM) all markedly inhibited 5 alpha-androstane-3 beta,17 beta-diol hydroxylation in a concentration-dependent manner, whereas triazole-type antimycotic drugs (fluconazole and itraconazole; 0.1-10 microM) had no inhibitory effect. The rank order of inhibitory potency of the imidazole-type antimycotic drugs was miconazole greater than clotrimazole greater than ketoconazole. In the case of clotrimazole, the inhibition was shown to be competitive in nature, with a Ki of 0.03 microM. The imidazole-type antimycotic drugs inhibited all three pathways of 5 alpha-androstane-3 beta,17 beta-diol hydroxylation to the same extent, which provides further evidence that, in rat prostate microsomes, a single cytochrome P450 enzyme catalyzes the 6 alpha-, 7 alpha-, and 7 beta-hydroxylation of 5 alpha-androstane-3 beta,17 beta-diol. These studies demonstrate that certain imidazole-type compounds are potent, competitive inhibitors of 5 alpha-androstane-3 beta,17 beta-diol hydroxylation by rat prostate microsomes, which is consistent with the effect of these antimycotic drugs on cytochrome P450 enzymes involved in the metabolism of other androgens and steroids.

I'd like to know why it isnt in the Hairloss regimen please CS?

Does it stress the liver when applied? (because pores are open and some KCZ/Mico gets absorved? but isnt it a very small amount?)

Also interesting:
http://inhumanexperiment.blogspot.com/2009/03/2-nizoral-shampoo-increases-hair-growth.html

http://inhumanexperiment.blogspot.com/2009/02/topical-ketoconazole-nizoral-increases.html

I have been using Revita shampoo, which contains ketoconazole, for over a year now. I seem to notice less shedding when I use it daily also.

It probably isn't included in the regime because as I understand keto is a toxic substance. I am actually using the keto 2% cream. After initailly using once everyday, I have now switched to EOD and am rotating it with spiro 5% (had a crazy reaction to spiro one night when I was first using it but I now believe that was because I was using too much - touch wood since using it once a day EOD, I haven't had any negative reactions). The toxicity issue of keto was a concern for me hence i've decided to use it EOD. Used Mico once and it gave me a headache so have backed off and not used it since. Going to also start using Adenogen as a form of growth/thickening stimulant - very expensive for what it is, but going to use it once a day and see how things go with it. Considered Renokin but not totally convinced by it at this point in time. Going to stick to this alongside the IH6 (in my case I really think the krill oil, antioxidant boost and EC are the key supps. Will look to add decalcify along the way to)

I've used keto shampoo for years now and I feel it is an important adjunct to my regimen. I would be uncomfortable using a keto cream and leaving in on for hours at a time. I've read comments from others who share the same view.

As for miconazole cream, I tried it twice and only on my hairline. Btw I did leave it on overnight. But trials had the same effect. I actually lost hair. Yes you read that correctly. My hairline, which was relatively intact, actually receded when I used the miconazole cream (2%). After the first time I thought that it was all in my mind. It wasn't. So be careful.

jmoss... hair doesnt work like that

You dont recede after 2 applications of mico..(that's physically impossible)
Maybe you just imagined it, or maybe you just had a bad hair day or something, it happens sometimes...

I am a skeptic at heart and I would never have believed it myself. But it did happen. The fact that it was my hairline (which I look at every day) and not in the vertex is very important.

Any way I still use Nizoral shampoo and I would encourage others to do the same. However I thought it was important to relay to others what my experience with miconazole was.

FireFist wrote:jmoss... hair doesnt work like that

You dont recede after 2 applications of mico..(that's physically impossible)
Maybe you just imagined it, or maybe you just had a bad hair day or something, it happens sometimes...

what do you mean you lost hair?
you lost 3-4 terminals hairs along the hairline?
you lost 25% of your hairline density over 2 mico applications?
you receded one inch further and it never came back?

The temple area receded somewhat but what troubles me is the area to the immediate left and right of center. It just receded. Not by an inch but maybe 4 or 5 mm.

FireFist wrote:what do you mean you lost hair?
you lost 3-4 terminals hairs along the hairline?
you lost 25% of your hairline density over 2 mico applications?
you receded one inch further and it never came back?

JDP/CS why isnt Mico/Niz not in the regimen?

Out of curiosity.. also any adverse Side effects?

I'd assume its because they are drugs and not natural and lithium has been shown to outperform ketoconazole in regards to seborrheic dermatitis if my memory serves me right.

Firefist, in regards to side effects, I think it was Decro (again could be wrong, all from memory) got reduced libido from using ketoconazole externally. Internally taking keto can be hard on the liver, so not advised. The sls in nizoral made my inflammation go crazy, however adding a ketoconazole cream to an sls shampoo, I no longer have this problem.

Thanks guys..

I'll try to bump one last time for cs and jdp to gain some knowledge =)

Does anyone know where to obtain keto powder? It would be better to mix pure keto with aloe gel or some other carrier rather than using the cream which has alcohol and other chemicals in it.