Immortal Hair
Would you like to react to this message? Create an account in a few clicks or log in to continue.

Search
 
 

Display results as :
 


Rechercher Advanced Search

Check Out Our Sponsors
Brought to you by
Hair Loss Forum
Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search
Latest topics
» Experimental aftermath.
Hair Growth Promoting Effect of Hottuynia cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells. EmptyYesterday at 9:11 am by CausticSymmetry

» ever hear of ayahuasca?
Hair Growth Promoting Effect of Hottuynia cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells. EmptyYesterday at 7:52 am by Zaphod

» Roles of gut microbiota in androgenetic alopecia: insights from Mendelian randomization analysis
Hair Growth Promoting Effect of Hottuynia cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells. EmptySun Nov 24, 2024 4:22 pm by CausticSymmetry

» Urolithin A
Hair Growth Promoting Effect of Hottuynia cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells. EmptySun Nov 24, 2024 4:32 am by CausticSymmetry

» coconut oil a DHT inhibitor?
Hair Growth Promoting Effect of Hottuynia cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells. EmptySun Nov 24, 2024 3:21 am by shaftless

» Challenging Old Dogmas
Hair Growth Promoting Effect of Hottuynia cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells. EmptySun Nov 17, 2024 7:26 am by CausticSymmetry

» Is this beneficial bacterial strain the Pièce de résistance?
Hair Growth Promoting Effect of Hottuynia cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells. EmptyFri Nov 15, 2024 10:27 am by CausticSymmetry

» Hyperthyroidism and iodine?
Hair Growth Promoting Effect of Hottuynia cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells. EmptyThu Nov 14, 2024 9:48 am by CausticSymmetry

» pentadecanoic acid
Hair Growth Promoting Effect of Hottuynia cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells. EmptyWed Nov 13, 2024 8:46 am by P88

Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search

Hair Growth Promoting Effect of Hottuynia cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells.

Go down

Hair Growth Promoting Effect of Hottuynia cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells. Empty Hair Growth Promoting Effect of Hottuynia cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells.

Post  CausticSymmetry Fri Oct 11, 2019 3:14 am

Biol Pharm Bull. 2019;42(10):1665-1673. doi: 10.1248/bpb.b19-00254.
Hair Growth Promoting Effect of Hottuynia cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells.
Kim J1, Shin JY1, Choi YH1, Jang M1, Nam YJ2, Lee SY1, Jeon J1, Jin MH1, Lee S1.
Author information
1
Research Park, LG Household & Healthcare Ltd.
2
Department of biotechnology, CHA University.

Houttuynia cordata (HC) is a traditional oriental herbal medicinal plant widely used as a component of complex prescriptions in Asia for alopecia treatment. The effect of HC on hair growth and its underlying mechanism, however, have not been demonstrated or clarified. In this study, we investigated the hair growth promoting effect of HC in cultured human dermal papilla cells (hDPCs). HC extract was found to stimulate the proliferation of hDPCs and this stimulation might be in part a consequence of activated cellular energy metabolism, because treatment of HC extract increased the generation of nicotinamide adenine dinucleotide (NADH) and ATP through increasing the mitochondrial membrane potential (ΔΨ). In the context of cell cycle, HC extract increased the expression of CDK4 and decreased the expression of CCNA2 and CCNB1, implying that HC extract might induce G1 phase progression of DPCs which resulted in enhanced proliferation. HC extract increased the expression of Bcl2 essential for maintaining hair follicle anagen stage and cell survival. On the contrary, the expression of p16 and p21 was down-regulated by HC extract. In addition, HC extract enhanced the secretion of platelet-derived growth factor (PDGF)-aa and vascular endothelial growth factor (VEGF) and induced phosphorylation of extracellular signal-regulated kinase (ERK) and AKT. Furthermore, HC extract prolonged anagen stage in organ cultured human hair follicles. Our data strongly suggest that HC extract could support hair growth by stimulating proliferation of DPCs and elongating anagen stage, resulted from enhanced cellular energy metabolism and modulation of gene expression related to cell cycle, apoptosis, and growth factors.

KEYWORDS:
Bcl2; Houttuynia cordata extract; hair growth; human dermal papilla cell

Full: https://www.jstage.jst.go.jp/article/bpb/42/10/42_b19-00254/_html/-char/en

https://www.iherb.com/pr/Wishtrend-Polyphenols-in-Propolis-15-Ampoule-1-01-fl-oz-30-ml/89235?=hil335

_________________
My regimen
http://www.immortalhair.org/mpb-regimen
(Primary site under construction: )

Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation

Primary site under construction:
https://immortalhair.org/

Archived as of 2022 here:
https://web.archive.org/web/20220330061828/https://www.immortalhair.org/
CausticSymmetry
CausticSymmetry
Admin

Posts : 14377
Join date : 2008-07-09

http://www.immortalhair.org/

Back to top Go down

Back to top

- Similar topics

 
Permissions in this forum:
You cannot reply to topics in this forum