Immortal Hair
Would you like to react to this message? Create an account in a few clicks or log in to continue.

Search
 
 

Display results as :
 


Rechercher Advanced Search

Check Out Our Sponsors
Brought to you by
Hair Loss Forum
Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search
Latest topics
» Experimental aftermath.
3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling. EmptyYesterday at 9:11 am by CausticSymmetry

» ever hear of ayahuasca?
3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling. EmptyYesterday at 7:52 am by Zaphod

» Roles of gut microbiota in androgenetic alopecia: insights from Mendelian randomization analysis
3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling. EmptySun Nov 24, 2024 4:22 pm by CausticSymmetry

» Urolithin A
3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling. EmptySun Nov 24, 2024 4:32 am by CausticSymmetry

» coconut oil a DHT inhibitor?
3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling. EmptySun Nov 24, 2024 3:21 am by shaftless

» Challenging Old Dogmas
3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling. EmptySun Nov 17, 2024 7:26 am by CausticSymmetry

» Is this beneficial bacterial strain the Pièce de résistance?
3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling. EmptyFri Nov 15, 2024 10:27 am by CausticSymmetry

» Hyperthyroidism and iodine?
3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling. EmptyThu Nov 14, 2024 9:48 am by CausticSymmetry

» pentadecanoic acid
3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling. EmptyWed Nov 13, 2024 8:46 am by P88

Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search

3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling.

2 posters

Go down

3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling. Empty 3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling.

Post  CausticSymmetry Thu Nov 03, 2016 2:17 am

Biomol Ther (Seoul). 2016 Nov 1;24(6):572-580. doi: 10.4062/biomolther.2016.183.
3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling.
Kim YE1, Choi HC1, Lee IC2, Yuk DY1, Lee H3, Choi BY3.

3-Deoxysappanchalcone (3-DSC) has been reported to possess anti-allergic, antiviral, anti-inflammatory and antioxidant activities. In the present study, we investigated the effects of 3-DSC on the proliferation of human hair follicle dermal papilla cells (HDPCs) and mouse hair growth in vivo. A real-time cell analyzer system, luciferase assay, Western blot and real-time polymerase chain reaction (PCR) were employed to measure the biochemical changes occurring in HDPCs in response to 3-DSC treatment. The effect of 3-DSC on hair growth in C57BL/6 mice was also examined. 3-DSC promoted the proliferation of HDPCs, similar to Tofacitinib, an inhibitor of janus-activated kinase (JAK). 3-DSC promoted phosphorylation of β-catenin and transcriptional activation of the T-cell factor. In addition, 3-DSC potentiated interleukin-6 (IL-6)-induced phosphorylation and subsequent transactivation of signal transducer and activator of transcription-3 (STAT3), thereby increasing the expression of cyclin-dependent kinase-4 (Cdk4), fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF). On the contrary, 3-DSC attenuated STAT6 mRNA expression and IL4-induced STAT6 phosphorylation in HDPCs. Finally, we observed that topical application of 3-DSC promoted the anagen phase of hair growth in C57BL/6 mice. 3-DSC stimulates hair growth possibly by inducing proliferation of follicular dermal papilla cells via modulation of WNT/β-catenin and STAT signaling.

KEYWORDS:
3-deoxysappanchalcone; C57BL/6 mice; Human hair follicle dermal papilla cells; STAT3; STAT6; WNT/β-catenin

_________________
My regimen
http://www.immortalhair.org/mpb-regimen
(Primary site under construction: )

Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation

Primary site under construction:
https://immortalhair.org/

Archived as of 2022 here:
https://web.archive.org/web/20220330061828/https://www.immortalhair.org/
CausticSymmetry
CausticSymmetry
Admin

Posts : 14377
Join date : 2008-07-09

http://www.immortalhair.org/

Back to top Go down

3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling. Empty Re: 3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling.

Post  shaftless Fri Nov 04, 2016 4:46 am

After a little research this chemical is found in sappanwood or indian redwood. It's used as a furniture dye. Would it be safe to get some of this dye and use it as a topical? Could be a little dangerous.

shaftless

Posts : 1408
Join date : 2012-08-12

Back to top Go down

Back to top

- Similar topics

 
Permissions in this forum:
You cannot reply to topics in this forum