Urolithin A

I tried the search option and couldn’t find many results on this supplement, so I thought I’d make it a topic…

Recently I listened to the following podcast discussing Urolithin A, and its potential health benefits as claimed in this episode and many studies are referenced on the website belonging to the guest.

https://podtail.com/en/podcast/bulletproof-radio/urolithin-a-s-secret-to-youthful-energy-and-the-fi/

CS, I would be intrigued to hear your thoughts on the claims made and your educated opinion in general with respect to Urolithin A; especially in relation to using it as a supplement in an arsenal to: reduce premature ageing, improve performance, improve energy levels, improve various bio markers in relation to better health and longevity.

Surprised there is no previous post on this, as there is mention in the literature on it.

I've looked into it on and off. Because this is emerging research, not to mention--pricey, the
potential Achilles heal is that its production is dependent on certain bacteria in the gut.

This reminds me of the mid-2000's when the search for optimal conditions for equol producers, that alleged molecule
that "hand-cuffs" DHT from receptors. I did a deep dive in those days and found some interesting things such as the type of food and supplements that would help it become active. I think there was a 40% probability that anyone could produce it on their own.

So with Urolithin A being a metabolite produced types of bacteria from ellagitannins found in foods like pomegranates and berries. However, only about 40% of people naturally produce it--so off-hand I do know that Dave Asprey has a financial interest in this--Are there less expensive ways to get the same results?

The claims of the product are here

https://www.timeline.com/studies

The new frontier in my opinion is to return keystone microbes that have been missing due to
industrialized food, agriculture methods and antibiotics.

Perhaps by optimizing gut bacteria will enhance the conversion of ellagitannins (such as pomegrante juice) to Urolithin A depends on specific gut bacteria. Since only 40% of people have the "right stuff" or have the correct strains, The following foods will help build this up over time:

Prebiotic like foods (feeders of bacteria) such as garlic, onions, and asparagus to increase their numbers, plus fermented foods like yogurt, kefir, sauerkraut, and kimchi to in order to restore potential keystone microbes.

Keystone, meaning ones that will allow other bacteria to survive.

It's estimated that as many as 50% of people have SIBO, so if that is the case, would be harder to make this within the gut without that supplement.