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Sebum and Hair Loss: A common thread?
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Smurfy
CausticSymmetry
Xenon
Columbo
AgapeBerry
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Sebum and Hair Loss: A common thread?
I’m aware that this may be a very simplified explanation for a very complex problem, with many underlying issues, as continually pointed out by CS and others here, but I’ve noticed sebum being a common issue that gets resolved during a variety of different hair loss protocols.
- Many topicals, including minoxidil, are thought to banish sebum, at least for a short while.
- Ketoconazole-based shampoos are quite drying and good at getting rid of sebum, supposedly shrinking the sebaceous glands by some 19% eventually if I recall right.
- Finasteride eliminated my sebum the days following taking it and many others report this effect, although some report the opposite - in which case I’d be interested to know how their hair faired.
- Low-dose Accutane has been touted by an ex-Merck researcher (according to the story that’s circulated some forums) as a regrowth tool, along with some anecdotal reports, and it is obviously very effective at eliminating sebum.
- A healthier diet, free of dairy and hormones or whatever doesn’t jive with your body is good for reducing sebum (many people have found success at fighting their acne by simply removing dairy from their diet for instance, but I don’t think diet is a one-size fits all kind of thing).
- LLLT has been found to be useful in treating acne.
And I'm sure there are others I'm missing.
Furthermore, the two specific times I’ve noticed the most shedding in my life have been while doing no-poo (where my oil did eventually settle down around the 1 month mark, but was still more present than when I shampooed) and during DT (which encouraged a lot of sebum out from my scalp but never seemed to solve the issue of reducing sebum production). Another note is that stress can also cause acne or increased sebum production. And of course stress is also implicated in hair loss.
I’ve been searching around for other ways to reduce sebum on acne forums and such, as accutane may not be easy to acquire for off-label use, and I don’t really have any acne to show a derm, but I do get an oily head later in the day. Not many seem to be as effective as accutane alone, but I’ve been trying to take a holistic approach to this. Anyway, over at cure zone I found some pretty remarkable claims for two methods of eliminating sebum/acne in adults who’ve had it for many years, them being multiple liver flushes and daily oil pulling.
I recall Prague being a huge proponent of oil pulling for hair loss and I did it for a few weeks but couldn’t wrap my head around how it might help, and eventually stopped. I’ve also completed a liver flush once before, not noticing any change in my wellbeing, but now I’m reading that it can take anywhere from 5-15 of them before people start seeing improvement in their ailment, in one case it took a 50 year old woman 10 of them before her sebum disappeared. There seemed to be more support for the liver flushes in terms of eliminating sebum than the oil pulling, but why not use both?
I’m interested in anyone’s input on the underlying scientific reasons for why sebum may play a role and any additions to the above, both in terms of remedies that reduce sebum or anything that increases sebum and correlatedly increases hair loss.
- Many topicals, including minoxidil, are thought to banish sebum, at least for a short while.
- Ketoconazole-based shampoos are quite drying and good at getting rid of sebum, supposedly shrinking the sebaceous glands by some 19% eventually if I recall right.
- Finasteride eliminated my sebum the days following taking it and many others report this effect, although some report the opposite - in which case I’d be interested to know how their hair faired.
- Low-dose Accutane has been touted by an ex-Merck researcher (according to the story that’s circulated some forums) as a regrowth tool, along with some anecdotal reports, and it is obviously very effective at eliminating sebum.
- A healthier diet, free of dairy and hormones or whatever doesn’t jive with your body is good for reducing sebum (many people have found success at fighting their acne by simply removing dairy from their diet for instance, but I don’t think diet is a one-size fits all kind of thing).
- LLLT has been found to be useful in treating acne.
And I'm sure there are others I'm missing.
Furthermore, the two specific times I’ve noticed the most shedding in my life have been while doing no-poo (where my oil did eventually settle down around the 1 month mark, but was still more present than when I shampooed) and during DT (which encouraged a lot of sebum out from my scalp but never seemed to solve the issue of reducing sebum production). Another note is that stress can also cause acne or increased sebum production. And of course stress is also implicated in hair loss.
I’ve been searching around for other ways to reduce sebum on acne forums and such, as accutane may not be easy to acquire for off-label use, and I don’t really have any acne to show a derm, but I do get an oily head later in the day. Not many seem to be as effective as accutane alone, but I’ve been trying to take a holistic approach to this. Anyway, over at cure zone I found some pretty remarkable claims for two methods of eliminating sebum/acne in adults who’ve had it for many years, them being multiple liver flushes and daily oil pulling.
I recall Prague being a huge proponent of oil pulling for hair loss and I did it for a few weeks but couldn’t wrap my head around how it might help, and eventually stopped. I’ve also completed a liver flush once before, not noticing any change in my wellbeing, but now I’m reading that it can take anywhere from 5-15 of them before people start seeing improvement in their ailment, in one case it took a 50 year old woman 10 of them before her sebum disappeared. There seemed to be more support for the liver flushes in terms of eliminating sebum than the oil pulling, but why not use both?
I’m interested in anyone’s input on the underlying scientific reasons for why sebum may play a role and any additions to the above, both in terms of remedies that reduce sebum or anything that increases sebum and correlatedly increases hair loss.
AgapeBerry- Posts : 103
Join date : 2014-02-11
Re: Sebum and Hair Loss: A common thread?
Not the entire answer, but definitely part of the equation i.e. if you're dripping with sebum your hair's going to struggle
... trap DHT and other crap, conversion of sebum to good knows what, prob cause inflammation, bacteria/fungal build up and also physically plug up the follicles, and effecting keratinization ( https://goo.gl/eZISFJ ) etc.
I went no poo for a good few years and retrospect was probably one of the causes of shedding. I'm now making sure to shampoo regularly but also treat my hair topically alternating between polysorbate 80 and bentonite clays (I've also been doing it on my nose and interestingly small hair are sprouting from the pores which were once blocked!)
I'm also about the start scalp peels as I imagine I have a bunch of sebum/keratinization weirdness build up (glycolic peel, salycilic scalp peel)
Internally, I find sebum is triggered by eating crap particularly fried foods (esp PUFA fried)
B Vits, esp pantothenic acid will reduce sebum. Vit A too (retinol e.g. liver)
Sebum management definitely one piece of the puzzle for sure
... trap DHT and other crap, conversion of sebum to good knows what, prob cause inflammation, bacteria/fungal build up and also physically plug up the follicles, and effecting keratinization ( https://goo.gl/eZISFJ ) etc.
I went no poo for a good few years and retrospect was probably one of the causes of shedding. I'm now making sure to shampoo regularly but also treat my hair topically alternating between polysorbate 80 and bentonite clays (I've also been doing it on my nose and interestingly small hair are sprouting from the pores which were once blocked!)
I'm also about the start scalp peels as I imagine I have a bunch of sebum/keratinization weirdness build up (glycolic peel, salycilic scalp peel)
Internally, I find sebum is triggered by eating crap particularly fried foods (esp PUFA fried)
B Vits, esp pantothenic acid will reduce sebum. Vit A too (retinol e.g. liver)
Sebum management definitely one piece of the puzzle for sure
Columbo- Posts : 444
Join date : 2011-08-03
Re: Sebum and Hair Loss: A common thread?
Is your hair short? I ask because the time I tried clay on my scalp, upon it drying and then rinsing it out, it seemed to take a lot of hairs with it.
I would be cautious with b5/Pantothenic acid. Hair loss has been anecdotally associated with it. I found a large, multiple year thread on an acne forum specifically about reversing hair loss that seemed to have been induced by vit b5. I've taken it a few different times when I had acne at high doses, prior to noticing my hair loss, of course that doesn't necessarily mean anything though.
I would be cautious with b5/Pantothenic acid. Hair loss has been anecdotally associated with it. I found a large, multiple year thread on an acne forum specifically about reversing hair loss that seemed to have been induced by vit b5. I've taken it a few different times when I had acne at high doses, prior to noticing my hair loss, of course that doesn't necessarily mean anything though.
AgapeBerry- Posts : 103
Join date : 2014-02-11
Re: Sebum and Hair Loss: A common thread?
Ha, yes. Buzzed right down. I have no idea how guys who don't have short hair use clay.
Interesting on B5.
How much B5 were you using? (I'm only doing 100% RDA)
What form were you using, natural or synthetic? (I'm using a natural form supplied by brewer's yeast)
Interesting on B5.
How much B5 were you using? (I'm only doing 100% RDA)
What form were you using, natural or synthetic? (I'm using a natural form supplied by brewer's yeast)
Columbo- Posts : 444
Join date : 2011-08-03
Re: Sebum and Hair Loss: A common thread?
As mentioned in my sebum thread, going without poo for only two weeks created an inflammatory cascade which caused my hair to shed rapidly. It's now worse than it has ever looked. It could be due to a substance called squalene peroxide, which, to put it bluntly, is sebum which turns bad and then becomes inflammatory. This substance is involved in the pathology of acne. When applied to animals, tests shown that it caused the development of acne in those areas. Seeing as the scalp produces so much of it, it makes sense that it gradually builds up at the root of the follicle and causes damage.
Still, don't be under any illusions that keeping sebum at bay is going to regrow your hair. sure it will slow it down (even halt it if combined with other anti-inflammatory measures), but it's not enough to regrow hair.
Still, don't be under any illusions that keeping sebum at bay is going to regrow your hair. sure it will slow it down (even halt it if combined with other anti-inflammatory measures), but it's not enough to regrow hair.
Xenon- Posts : 1601
Join date : 2012-05-03
Location : Alpha Draconis
Re: Sebum and Hair Loss: A common thread?
Is there a connection between sebum and hair loss? There is, however it's not the complete picture.
Regarding shampoo (I find it's very useful to avoid one's containing aggravating/irritants such as SLS, which trips the
transient receptor potential vanilloid 1 receptor. At any rate, there are ways to reduce sebum (avoid ACCUTANE) if you're interested in your health. Better to hit the animal form vitamin A (won't destroy you).
When hair loss was really winning (well over 10 years ago), my sebum problem then was always present.
I had tried methods hitting the sebum directly (they worked) but the hair loss problem itself was not corrected.
To be more technical about it, the sebum pathway involves Glycogen synthase kinase 3 beta (GSK3Beta) that inhibit the Wnt/Beta-catenin pathway (necessary for hair growth). But altering that alone doesn't fix it. Hair loss is an immune regulation problem partly challenged by detoxification pathways not working correctly--in a toxic world.
Regarding shampoo (I find it's very useful to avoid one's containing aggravating/irritants such as SLS, which trips the
transient receptor potential vanilloid 1 receptor. At any rate, there are ways to reduce sebum (avoid ACCUTANE) if you're interested in your health. Better to hit the animal form vitamin A (won't destroy you).
When hair loss was really winning (well over 10 years ago), my sebum problem then was always present.
I had tried methods hitting the sebum directly (they worked) but the hair loss problem itself was not corrected.
To be more technical about it, the sebum pathway involves Glycogen synthase kinase 3 beta (GSK3Beta) that inhibit the Wnt/Beta-catenin pathway (necessary for hair growth). But altering that alone doesn't fix it. Hair loss is an immune regulation problem partly challenged by detoxification pathways not working correctly--in a toxic world.
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Re: Sebum and Hair Loss: A common thread?
Interesting you mention how liver flushes deal with sebum production. That kind of solidifies a theory I've had. I've always thought that sebum was mens form of a detox channel, either secondary or tertiary. If the liver has impaired function from overburden, hormones, etc, the body has to find another site to dump out the toxins from circulation. The skin being the biggest organ, why not? Especially when it can be readily dispersed via the sebaceous glands.
In the past when I've eaten junk, refined carbs, especially bad oils, sebum would increase tremendously, and noting the correlation, I figured the toxic waste materials were being purged via the sebum, as I'm sure my liver wasn't in the best of condition. Since eating so much better and including daily liver tonics, my sebum doesn't get very bad. It's thinner, slower to excrete, and doesn't require washing nearly as often. I feel hair loss from sebum is your body's way of outwardly telling you it's having major problems dealing with internal insults, and it startles you to get your attention.
I believe the sebum itself may induce hypoxic reactions. We know bad oils and such in the arteries block cellular oxygenation, so when these coat the head and follicles, the same thing may happen, hence the downfall of hair. Add to this the itch, which may be anaerobic bacteria, fungi, some organism flourishing in the newly compromised environment. Though I'm still wondering in all this, why after some time the hair doesn't begin to grow back, if indeed sebum is a big player... unless sebum plugs are very embedded, or peroxides have done real damage over time.
In the past when I've eaten junk, refined carbs, especially bad oils, sebum would increase tremendously, and noting the correlation, I figured the toxic waste materials were being purged via the sebum, as I'm sure my liver wasn't in the best of condition. Since eating so much better and including daily liver tonics, my sebum doesn't get very bad. It's thinner, slower to excrete, and doesn't require washing nearly as often. I feel hair loss from sebum is your body's way of outwardly telling you it's having major problems dealing with internal insults, and it startles you to get your attention.
I believe the sebum itself may induce hypoxic reactions. We know bad oils and such in the arteries block cellular oxygenation, so when these coat the head and follicles, the same thing may happen, hence the downfall of hair. Add to this the itch, which may be anaerobic bacteria, fungi, some organism flourishing in the newly compromised environment. Though I'm still wondering in all this, why after some time the hair doesn't begin to grow back, if indeed sebum is a big player... unless sebum plugs are very embedded, or peroxides have done real damage over time.
Smurfy- Posts : 325
Join date : 2010-11-25
Re: Sebum and Hair Loss: A common thread?
Been using dr bronners. Someone point me to the best shampoo to use.
Growdamnit- Posts : 1081
Join date : 2012-10-21
Re: Sebum and Hair Loss: A common thread?
Though I'm still wondering in all this, why after some time the hair doesn't begin to grow back, if indeed sebum is a big player.
It may mainly be due to low levels of IGF-1. According to the following study, increased IGF-1 reduces the inflammatory response and oxidative stress. Reduced IGF-1 therefore would likely lead to a pro-inflammatory environment, which would cause the follicle to miniaturize prematurely, thus having no regenerative capacity. DHT is said to assist in the reduction of IGF-1...
IGF-1 reduces inflammatory responses, suppresses oxidative stress, and decreases atherosclerosis progression in ApoE-deficient mice.
Sukhanov S1, Higashi Y, Shai SY, Vaughn C, Mohler J, Li Y, Song YH, Titterington J, Delafontaine P.
Author information
Abstract
OBJECTIVE:
Whereas growth factors, via their ability to stimulate vascular smooth muscle cell (VSMC) proliferation and migration, have been thought to play a permissive role in atherosclerosis initiation and progression, the role of insulin-like growth factor-1 (IGF-1) is unknown. Here we report for the first time that IGF-1 infusion decreased atherosclerotic plaque progression in ApoE-deficient mice on a Western diet.
METHODS AND RESULTS:
ApoE-null mice (8 weeks) were infused with vehicle or recombinant human IGF-1 and fed a high-fat diet for 12 weeks. Analysis of aortic sinuses revealed that IGF-1 infusion decreased atherosclerotic plaque progression and macrophage infiltration into lesions. Furthermore, IGF-1 decreased vascular expression of the proinflammatory cytokines interleukin-6 and tumor necrosis factor-alpha, reduced aortic superoxide formation and urinary 8-isoprostane levels, and increased aortic pAkt and eNOS expression and circulating endothelial progenitor cells, consistent with an antiinflammatory, antioxidant, and prorepair effect on the vasculature.
CONCLUSIONS:
Our data indicate that an increase in circulating IGF-1 reduces vascular inflammatory responses, systemic and vascular oxidant stress and decreases atherosclerotic plaque progression. These findings have major implications for the treatment of atherosclerosis.
Xenon- Posts : 1601
Join date : 2012-05-03
Location : Alpha Draconis
Re: Sebum and Hair Loss: A common thread?
Xenon wrote:As mentioned in my sebum thread, going without poo for only two weeks created an inflammatory cascade which caused my hair to shed rapidly. It's now worse than it has ever looked. It could be due to a substance called squalene peroxide, which, to put it bluntly, is sebum which turns bad and then becomes inflammatory. This substance is involved in the pathology of acne. When applied to animals, tests shown that it caused the development of acne in those areas. Seeing as the scalp produces so much of it, it makes sense that it gradually builds up at the root of the follicle and causes damage.
Still, don't be under any illusions that keeping sebum at bay is going to regrow your hair. sure it will slow it down (even halt it if combined with other anti-inflammatory measures), but it's not enough to regrow hair.
Well I'm not really sure about anything. I think for some people, depending on how much it's supressed and how many other factors are or are not contributing to their hair loss, it might, and people have indeed reported that it does in the case of low-dose accutane. I can't think of any other reasons why low dose accutane could be beneficial for hair other than eliminating sebum production, it's been reported to cause hair loss in the higher, prescribed doses, but these beneficial reports are still sparse and anecdotal.
I originally forgot to mention NoFap (abstaining from ejaculation for months at a time) as another strategy that both reduces sebum/acne in people and has been claimed to halt shedding and even regrow some hair.
Last edited by toolsmakingtools on Fri Aug 07, 2015 9:53 am; edited 4 times in total
AgapeBerry- Posts : 103
Join date : 2014-02-11
Re: Sebum and Hair Loss: A common thread?
Columbo wrote:Ha, yes. Buzzed right down. I have no idea how guys who don't have short hair use clay.
Interesting on B5.
How much B5 were you using? (I'm only doing 100% RDA)
What form were you using, natural or synthetic? (I'm using a natural form supplied by brewer's yeast)
I was using 1 - 1.5 grams a day of synthetic B5 without more than 1 or 2 other b vitamins. I'm sure others using it for acne were also taking synthetic. That's a good point.
AgapeBerry- Posts : 103
Join date : 2014-02-11
Re: Sebum and Hair Loss: A common thread?
I think it could be possible that a lot of men speed up their hair loss by thinking that once they shave their heads they no longer need to clean their hair/head with shampoo, causing the sebum to build up quicker and block or cause infections to the hair follicles.
australian- Posts : 73
Join date : 2015-06-29
Re: Sebum and Hair Loss: A common thread?
Smurfy wrote:Interesting you mention how liver flushes deal with sebum production. That kind of solidifies a theory I've had. I've always thought that sebum was mens form of a detox channel, either secondary or tertiary. If the liver has impaired function from overburden, hormones, etc, the body has to find another site to dump out the toxins from circulation. The skin being the biggest organ, why not? Especially when it can be readily dispersed via the sebaceous glands.
Over the years I've come to similar thoughts...
I get mild keratosis pilaris on the backs of my arms, "caused by excess keratin and sebum forming a “scaly plug” that stops up the opening of the hair follicle."
I did a liver flush a few years back and noticed a week or two later the KP had completely gone for the first time in my life. I didn't immediately make the connection. Couple of other observations
Also my KP would get worse with binge drinking which would also obviously burden the liver. (And also happens I shed most when having 2-3 years partying hard on weekends)
I also noticed that having a long bath once per week and my KP lessens too ... maybe soaking in the bath detoxes / exfoliates toxins, sebum and gunk from the skin? I don't get the same effect with showering.
I wonder if what's been happening with my arm follicles has been happening with my scalp follicles?!
(Vitamin A from liver has recently fixed my KP, BTW. Hopefully means my scalp follicles are getting healthier too)
Columbo- Posts : 444
Join date : 2011-08-03
Re: Sebum and Hair Loss: A common thread?
I have quite long hair (to my upper lip) and no problem with clay. You have to add little watter if you feel it is too dry at temples. No hair loss from it. It is 10x better then any shampoo I have ever tried. I use it instead of shampoo once/twice a week. And also no poo for sure.
It clean your scalp extremely well, just try it on your nose or face and your skin became really smooth.
It clean your scalp extremely well, just try it on your nose or face and your skin became really smooth.
lamka- Posts : 106
Join date : 2013-08-24
Re: Sebum and Hair Loss: A common thread?
lamka wrote:I have quite long hair (to my upper lip) and no problem with clay. You have to add little watter if you feel it is too dry at temples. No hair loss from it. It is 10x better then any shampoo I have ever tried. I use it instead of shampoo once/twice a week. And also no poo for sure.
It clean your scalp extremely well, just try it on your nose or face and your skin became really smooth.
good stuff. been trying it on my nose too, pores are all unblocking and lots of tiny hairs popping out
gonna need to start shaving my nose lol
Columbo- Posts : 444
Join date : 2011-08-03
Re: Sebum and Hair Loss: A common thread?
Columbo wrote:lamka wrote:I have quite long hair (to my upper lip) and no problem with clay. You have to add little watter if you feel it is too dry at temples. No hair loss from it. It is 10x better then any shampoo I have ever tried. I use it instead of shampoo once/twice a week. And also no poo for sure.
It clean your scalp extremely well, just try it on your nose or face and your skin became really smooth.
good stuff. been trying it on my nose too, pores are all unblocking and lots of tiny hairs popping out
gonna need to start shaving my nose lol
Hahaha man, that does not happened to me, but the "clean" effects on the nose last few days. Similar effect I got from tanning. Really hot water unblock pores too, but not as good as clay. In the past I had some problems with dandruff. I was doing lot of things to fix that issue. (intermittent fasting, raw veggies, no sugar no milk, no wheat, nothing processed, then I tried Peat inspired diet). I do not really know what helped me, but now I do sometimes drink green clay internally and nearly every day I drink unpasteurized acv with honey (organic, from my neighbour). Raw organic goat milk and goat products have no acne or sebum effect to me.
I also had keratosis above my elbows but it was 2 years ago. Now I do not have them at all.
What is worth :
An update on the role of the sebaceous gland in the pathogenesis of acne
Growth hormone (GH) activity is considered to be mainly attributed to IGF but GH has also been shown to exhibit direct effects on human skin cells.44 The increased serum GH levels in acromegaly are associated with enhanced sebum secretion,45 an observation that could be confirmed by GH treatment of human SZ95 sebocytes in vitro.46 In acne vulgaris, increased sebum production peaks in mid-adolescence at a time that GH and IGF-I reach their highest serum levels.47 In mini rats, suppression of GH gene expression by an antisense transgene, leads among to thinner skin with less collagen and increase of subcutaneous adipose tissue also to small-sized sebaceous glands.48
Increased serum levels of IGF-I have been observed in adult women and men with acne and the number of total acne lesions, inflammatory lesions, serum levels of 5α-DHT and DHEA sulphate, each correlated with serum IGF-I levels in women with acne.49,50 A correlation between the mean facial sebum excretion rate and serum IGF-I levels has been demonstrated in postadolescent acne patients.51 IGF-I has been localised to the peripheral cells of sebaceous glands in the rat,52 while in human skin the strongest expression of IGF-I protein has been found in maturing sebocytes and suprabasal cells of sebaceous ducts.53 The expression of IGF-I receptor mRNA is the strongest in basal cells of sebaceous glands and immature sebocytes, whereas IGF-I receptor protein expression was uniform and intense in all regions of the gland.53 In animal studies, IGF-I has been shown to stimulate sebocyte differentiation in vitro especially in combination with GH,47 while in human keratinocytes it acts as a mitogen.54 On the other hand, in humans, IGF-I plays a key role in the induction of lipid synthesis in human sebocytes.46,55 In SEB-1 sebocytes, IGF-I increases lipogenesis by the induction of sterol response element-binding protein-1 (SREBP-1)55 through activation of PI3K/Akt and MAPK/ERK-signal transduction pathway.56 SREBP-1 preferentially regulates genes of fatty acid synthesis.56 In the hamster ear sebaceous model, androgens rapidly induce the expression of SREBP-1.57 In addition, an interaction between the IGF-I and estradiol signalling pathway has been described in human SZ95 sebocytes, implicating that estrogens may have an indirect effect on the pathogenesis of acne.46
I think that high IGF-1 are positively connected to sebum and acne. So thats why young teenagers gets acne (because of low SHBG and high IGF-1). Caffeine increase your SHBG but depletes B1 vitamins.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051853/
Edit : I have seen some people cured their fungus and sebum problems with soap with sulfur + borax. I have talked about borax and fungus long time ago but it is really effective (just google it).
Topically green tea also reduces sebum production. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738281/)
Steady and statistically significant reductions in sebum secretions were noted for mono (green tea) ...
Epsom salt baths are know to detoxyfe your body and helps you to deal with inflamantion (http://www.acne.org/messageboard/topic/284304-hello-huge-thanks-to-this-forum-im-100-clear/ - random find).
http://www.worldhairloss.org/index.php/forums/viewthread/93/ this huge posts have really interesting informations. I recommend you to read it.
lamka- Posts : 106
Join date : 2013-08-24
Re: Sebum and Hair Loss: A common thread?
I think that high IGF-1 are positively connected to sebum and acne
Well, for me personally, I know for certain that going without washing my scalp for a short period caused severe irritation and shedding. Yet, when I started washing again, the irritation and shedding stopped. I also read that serum levels are stable in balding men - just not in scalp tissue / follicles.
Another interesting study I read, is the inverse correlation between black tea and IGF-1. Black tea is reported to decrease IGF-1 levels. As I mentioned before, I've had a life long black tea habit -- drinking between 9 or 10 cups per day for years. IDK why but I had a mild and ongoing hunch that black tea was somehow adding to my hairloss problems. I stopped drinking the stuff about 5 weeks ago or so, and what I have noticed, is some subtle changes in beard, brows and eye lash density. They have thickened up to an extent, which I was surprised to see, but, as of yet, no improvement in scalp hair thickness.
ETA: so it might be, that genetics are involved in downregulating IGF-1 receptors in scalp follicles, thus even if IGF-1 serum levels are corrected, it wont make any difference if receptors have been genetically reduced.
Black tea polyphenols inhibit IGF-I-induced signaling through Akt in normal prostate epithelial cells and Du145 prostate carcinoma cells.
Klein RD1, Fischer SM.
Author information
Abstract
Tea polyphenols have been proposed as potential chemopreventive agents against prostate cancer, primarily because of their high intake by populations with reduced cancer incidence and their reported ability to inhibit proliferation and increase apoptosis in prostate cancer cells in culture. Insulin-like growth factor-I (IGF-I) has been implicated as a risk factor for the development of prostate cancer by epidemiological studies and has been shown to be causative in animal models. One of the primary signal transduction pathways activated by IGF-I binding to its receptor is the Akt pathway. We determined that phosphorylated Akt levels are very low in serum-starved human normal prostate epithelial cells (PrEC) and Du145 prostate carcinoma cells, and that treatment of these cells with IGF-I results in a rapid and sustained phosphorylation of Akt. Pre-treatment of PrEC and Du145 cells with doses as low as 20 microg/ml of a mixture of black tea polyphenols (BTP) substantially reduced IGF-I-mediated Akt phosphorylation. This effect of BTP appears to be due partially to the reduced autophosphorylation of IGF-I receptor-1 in BTP-treated cells. BTP pre-treatment also decreased downstream effects of Akt activation including phosphorylation of glycerol synthase kinase-3, increased cyclin D1 protein levels and increased DNA synthesis. Our results indicate that polyphenols from black tea inhibit the IGF-I signal transduction pathway, which has been linked to increased prostate cancer incidence in human populations and, therefore, provide further support for the potential of BTP to prevent prostate cancer.
Xenon- Posts : 1601
Join date : 2012-05-03
Location : Alpha Draconis
Re: Sebum and Hair Loss: A common thread?
Yes but too much of igf-1 is as bad as too much of SHBG. To low igf-1 is also bad as well as low shbg. But CS has in past pointed out that young man tend to have higher igf-1 (which trigger their baldness).
Note that balding men take drugs for reducing prostate size (because they have lot of igf-1). On the other hand igf-1 is supposed to be good in scalp because it grows hair. So systematic IGF-1 and IGF-1 in our scalps are different terms I think.
Your black tea would be high in heavy metals. It is usual that teas are high in it. When you look at japanese people they drink more tea than europeans/americans. So I would not blame black tea to cause more aggressive hair loss.
Look at this : http://www.ncbi.nlm.nih.gov/pubmed/12894070 (The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia.)
Then comapare it with this study
From wiki : SHBG has both enhancing and inhibiting hormonal influences. It decreases with high levels of insulin, growth hormone, insulin-like growth factor 1 (IGF-1), androgens, prolactin and transcortin. https://en.wikipedia.org/wiki/Sex_hormone-binding_globulin
Note that balding men take drugs for reducing prostate size (because they have lot of igf-1). On the other hand igf-1 is supposed to be good in scalp because it grows hair. So systematic IGF-1 and IGF-1 in our scalps are different terms I think.
Your black tea would be high in heavy metals. It is usual that teas are high in it. When you look at japanese people they drink more tea than europeans/americans. So I would not blame black tea to cause more aggressive hair loss.
Look at this : http://www.ncbi.nlm.nih.gov/pubmed/12894070 (The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia.)
Then comapare it with this study
http://www.ncbi.nlm.nih.gov/pubmed/14758568The frequency of subnormal values in SHBG, FSH, testosterone and epitestosterone (but not in free androgen index) was significant in the balding men. A borderline significant trend was recorded with respect to increased levels in 17OH-P and prolactin.
From wiki : SHBG has both enhancing and inhibiting hormonal influences. It decreases with high levels of insulin, growth hormone, insulin-like growth factor 1 (IGF-1), androgens, prolactin and transcortin. https://en.wikipedia.org/wiki/Sex_hormone-binding_globulin
lamka- Posts : 106
Join date : 2013-08-24
Re: Sebum and Hair Loss: A common thread?
I'll check your links out in a bit, Lamka, as I got to get my ass out somewhere. But just thought I'd mention briefly about my former tea habit (without taking this thread OT) When I mentioned this in another forum, people mentioned metals in tea, too, so I then wondered if the nichrome heating element in the bottom of the electrical kettle had something to do with this because I noticed metallic chippings in the bottom of the kettle whenever I went to fill it. These chippings have obviously broken away from the nichrome element, so I might have been, unknowingly, ingesting nickel into my body with every cup of tea I had.
As mentioned an unexpected side effect has been increased beard, eye brow, eye lash thickness (all within the space of 5 weeks). My eyes have also become whiter and the colour of my eyes more saturated too. This is not me imagining things either, when there are changes with my body I notice it, but there has been no improvement in scalp hair quality.
However I couldn't particularly say for certain if it metal, or perhaps too much heat stress from too many hot drinks. my body temperature has stabilized enormously since giving up hot drinks, so there could be something in that.
As mentioned an unexpected side effect has been increased beard, eye brow, eye lash thickness (all within the space of 5 weeks). My eyes have also become whiter and the colour of my eyes more saturated too. This is not me imagining things either, when there are changes with my body I notice it, but there has been no improvement in scalp hair quality.
However I couldn't particularly say for certain if it metal, or perhaps too much heat stress from too many hot drinks. my body temperature has stabilized enormously since giving up hot drinks, so there could be something in that.
Xenon- Posts : 1601
Join date : 2012-05-03
Location : Alpha Draconis
Re: Sebum and Hair Loss: A common thread?
I have found this study about teas and heavy metals.
http://www.hindawi.com/journals/jt/2013/370460/
http://www.hindawi.com/journals/jt/2013/370460/
Thats interesting because I have noticed that in one video Danny Roddy used some kind of glass kettle. This kind should not have any heavy metals in I think.I then wondered if the nichrome heating element in the bottom of the electrical kettle had something to do with this
lamka- Posts : 106
Join date : 2013-08-24
Re: Sebum and Hair Loss: A common thread?
Since I've completed a Hulda Clark liver flush, oil pulling once a day, consistently drinking 2L of water a day, and taking a tbsp of ACV (as per glowing reviews on acne.org and various people on these forums who take it for hair) the past couple days, my sebum is way down, even after a night of drinking there's hardly any shine on my forehead when it's usually quite noticeable.
AgapeBerry- Posts : 103
Join date : 2014-02-11
Re: Sebum and Hair Loss: A common thread?
toolsmakingtools wrote:Since I've completed a Hulda Clark liver flush, oil pulling once a day, consistently drinking 2L of water a day, and taking a tbsp of ACV (as per glowing reviews on acne.org and various people on these forums who take it for hair) the past couple days, my sebum is way down, even after a night of drinking there's hardly any shine on my forehead when it's usually quite noticeable.
Welp it turned out, at least in the short-term, that once I started a new job and had higher stress levels, my sebum returned nearly back to what it used to be, which was a shiny forehead and t-zone by around about noon. Since I've added 70 billion bacteria (probiotics) spaced around every meal of my day and some resistant starch (prebiotics) in the morning, I've been getting consistent days with little to no visible sebum on my forehead/scalp/face. This could be in part to my strategies quoted above starting to kick in, but I think the bulk of it is in the pre and probiotics.
I still can't say with certainty that sebum is the main culprit of my hairloss, and it's too early to tell whether my regimine not it's have a positive effect on my hair, but I don't plan on stopping it anytime soon, reasons being it's very affordable for me now and there's the added benefit of it greatly aiding digestion (for more troublesome foods or if you eat a ton of calories and don't want to feel all bloated and tired afterward.
A few years ago when I was struggling with acne I discovered the probiotics worked great for ridding acne, well my acne eventually left but my oil remained. I was only taking about 14 -28 billion bacteria (1-2 capsules) per day for my acne, as I wanted to extend my bottles and that was enough to clear me up, and I've since tried 14- 42 billion for a couple months with no success in treating hair loss (I didn't check my sebum levels as I hadn't correlated that with hair loss yet). Now I'm going to be taking about 70 billion probiotics spread out with each meal of the day for 6+ months, although unfortunately it will be close to impossible to say how effective it is for hairloss as I haven't been taking all of my other supplements long enough (< 4 months) to rule them out if there's success along with having just ordered a laser helmet. O I've also been juicing for just under a month, so hard to say, but I think it is relatively clear that the pre and probiotics and large enough doses have been essentially elminating my sebum, when I miss a day, the oil comes back. But with these higher doses, even stressful days don't cause much noticeable sebum at my hairline.
AgapeBerry- Posts : 103
Join date : 2014-02-11
Re: Sebum and Hair Loss: A common thread?
Anyone else having success with Probiotics? Dairy free ones?
ghai018- Posts : 193
Join date : 2012-02-16
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