Macrophages contribute to the cyclic activation of adult hair follicle stem cells.

PLoS Biol. 2014 Dec 23;12(12):e1002002. doi: 10.1371/journal.pbio.1002002. eCollection 2014.
Macrophages contribute to the cyclic activation of adult hair follicle stem cells.
Castellana D1, Paus R2, Perez-Moreno M1.

Skin epithelial stem cells operate within a complex signaling milieu that orchestrates their lifetime regenerative properties. The question of whether and how immune cells impact on these stem cells within their niche is not well understood. Here we show that skin-resident macrophages decrease in number because of apoptosis before the onset of epithelial hair follicle stem cell activation during the murine hair cycle. This process is linked to distinct gene expression, including Wnt transcription. Interestingly, by mimicking this event through the selective induction of macrophage apoptosis in early telogen, we identify a novel involvement of macrophages in stem cell activation in vivo. Importantly, the macrophage-specific pharmacological inhibition of Wnt production delays hair follicle growth. Thus, perifollicular macrophages contribute to the activation of skin epithelial stem cells as a novel, additional cue that regulates their regenerative activity. This finding may have translational implications for skin repair, inflammatory skin diseases and cancer.

Full Study: http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1002002

Nice post, CS. It confirms what was mentioned in the thread about chlorine dioxide.

Why would this macrophage stuff be heralded as a breakthrough when it is known since long ago..
2007 nonetheless. I really believe no cure will come because they play around with bald men hopes with all these headlines which play around with"cure" or whatever etc..

http://jcb.rupress.org/content/176/7/891a.full

What o you think CS what could be the reason for this to happen after 7+ years. to rehash some "breakthrough"

tooyoungforthis wrote:Why would this macrophage stuff be heralded as a breakthrough when it is known since long ago..
2007 nonetheless. I really believe no cure will come because they play around with bald men hopes with all these headlines which play around with"cure" or whatever etc..

http://jcb.rupress.org/content/176/7/891a.full

What o you think CS what could be the reason for this to happen after 7+ years. to rehash some "breakthrough"

Yes, exactly. Just from observation all of the "breakthroughs" from headlines that imply or promise a "cure" never come to fruition.

I believe the real reason why a basic cure doesn't exist is that multiple targets/reasons exist for hair loss and not an single or isolate approach works for everyone. I would consider myself cured of sorts...but not really, I wouldn't even try to go without treatment, because chances are, my hair would collapse.

That being said though, I think it really helps to acquire foundation nutrients (especially minerals), because the results from any treatment will work more effectively.

I, too share the same opinion. Hair loss can be prevented but can not be ''cured''. In terms of having hair (health) it's necessarily to put restorative good work and working on areas your individuality is particularly sensitive. For me it's dental health, emotional stress and keeping repair mechanisms OK, while cheating with diet and/or intoxicating my self in the industry. I would also have to expose myself to any sun rays that's available now. It's a bit absurd to think of it as a regimen, since to put it down it comes to being wild animal with access to good water, good food and lack of damage all modern society is exposed. ''All in one'' cures sound more like marketing than any kind of logic to me...

CF wrote:Nice post, CS.  It confirms what was mentioned in the thread about chlorine dioxide.

I agree.
Use chlorine dioxide and notice good results compared with other products I've used.


At the end of my 5th cycle show progress with photo

ubraj - I also agree that a viral component can exist. The origin of such a virus more often than not comes from vaccinations. And any disruption in detoxification will only exacerbate this condition. Mold toxins are among the worst, if not the worst type of infection possible from a long term, chronic inflammatory standpoint.

If mold toxins are other major players are not present, supplements such as Ecklonia cava and grape seed extract (and vitamin C) are effective against a wide variety of viruses.