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Beta-Sitosterol Impedes Vitamin D Absorption
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Beta-Sitosterol Impedes Vitamin D Absorption
For those wondering why they cant raise their Vitamin D levels no matter how much Vitamin D they take this could be the answer.
http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201100055/abstract
http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201100055/abstract
Phytosterols can impair vitamin D intestinal absorption in vitro and in miceAurélie Goncalves1,2,3, Béatrice Gleize1,2,3, Romain Bott1,3, Marion Nowicki1,2,3, Marie-Josèphe Amiot1,3, Denis Lairon1,2,3, Patrick Borel1,2,3, Emmanuelle Reboul1,2,3,*Article first published online: 29 JUN 2011
Abstract
Scope: Adequate vitamin D status is necessary and beneficial for health, although deficiency and insufficiency are very common. As cholecalciferol (vitamin D3) structure is close to cholesterol structure, we hypothesized that phytosterols, frequently used to decrease cholesterol, intestinal absorption and consequently to reduce hypercholesterolemia, may also interact with cholecalciferol absorption.
Methods and results: β-Sitosterol effect on cholecalciferol postprandial response was first assessed in mice. We then evaluated the effect of different sterols on (i) cholecalciferol micellar incorporation, (ii) cholecalciferol apical uptake and (iii) basolateral efflux in vitro or ex vivo. In mice, cholecalciferol bioavailability was 15-fold lower in the presence of β-sitosterol (p<0.05). This can partly be explained by the fact that phytosterols significantly impaired cholecalciferol incorporation into mixed micelles (from −16 to −36% depending on sterol micellar composition). This can also be due to the fact that in Caco-2 cells and mouse intestinal explants, phytosterols significantly lowered cholecalciferol apical uptake (from −13 to −39%). Conversely, phytosterols had no effect on cholecalciferol secretion at the basolateral side of Caco-2 cells.
Conclusion: The present data suggest for the first time that phytosterols can interact with vitamin D3 intestinal absorption. This interaction can be explained by a competition for micellar incorporation and for apical uptake.
liverock- Posts : 20
Join date : 2010-01-09
Re: Beta-Sitosterol Impedes Vitamin D Absorption
Beta-sitosterol also reduces the absorption of cholesterol, which is the metabolic precursor of vitamin D.
imprisoned-radical- Posts : 493
Join date : 2011-08-10
Re: Beta-Sitosterol Impedes Vitamin D Absorption
This article recommends getting round the problem by taking Beta-Sitosterol and Vitamin D at different times of the day and discusses possible interactions between phytosterols and Vitamin A&E besides Vitamin D.
http://www.healthyfellow.com/876/natural-interactions/
http://www.healthyfellow.com/876/natural-interactions/
liverock- Posts : 20
Join date : 2010-01-09
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