Caffeine, niacinamide, & aspirin. Why?

Where is the proof? I'd like to discuss it...

the proof of what??? be specific.

to remove nitric oxide in the scalp

and uncouple the mitochondria in the scalp

1. NIACINAMIDE
http://www.ncbi.nlm.nih.gov/pubmed/17147561
http://www.ncbi.nlm.nih.gov/pubmed/18492135
http://www.ncbi.nlm.nih.gov/pubmed/25399625
http://www.ncbi.nlm.nih.gov/pubmed/17147561
http://www.ncbi.nlm.nih.gov/pubmed/24635573
http://www.ncbi.nlm.nih.gov/pubmed/18492206

1.1 Hyperpigmentation and Skin Aging (niacinamide)
http://www.ncbi.nlm.nih.gov/pubmed/18492135
http://www.ncbi.nlm.nih.gov/pubmed/25399625
http://www.ncbi.nlm.nih.gov/pubmed/24993939
http://www.ncbi.nlm.nih.gov/pubmed/16029679
http://www.ncbi.nlm.nih.gov/pubmed/18047609
http://www.ncbi.nlm.nih.gov/pubmed/23355788
http://www.ncbi.nlm.nih.gov/pubmed/19845667
http://www.ncbi.nlm.nih.gov/pubmed/24033822
http://www.ncbi.nlm.nih.gov/pubmed/21822427
http://www.ncbi.nlm.nih.gov/pubmed/16766489
http://www.ncbi.nlm.nih.gov/pubmed/15807725

1.2 UV Damage (niacinamide)
http://www.ncbi.nlm.nih.gov/pubmed/12615518
http://www.ncbi.nlm.nih.gov/pubmed/19804594
http://www.ncbi.nlm.nih.gov/pubmed/22123419
http://www.ncbi.nlm.nih.gov/pubmed/24798949
http://www.ncbi.nlm.nih.gov/pubmed/22709272
http://www.ncbi.nlm.nih.gov/pubmed/23349012
http://www.ncbi.nlm.nih.gov/pubmed/23397947
http://www.ncbi.nlm.nih.gov/pubmed/24313740
http://www.ncbi.nlm.nih.gov/pubmed/20354654
http://www.ncbi.nlm.nih.gov/pubmed/20492562
http://www.ncbi.nlm.nih.gov/pubmed/19028705
http://www.ncbi.nlm.nih.gov/pubmed/17882270
http://www.ncbi.nlm.nih.gov/pubmed/15748504
http://www.ncbi.nlm.nih.gov/pubmed/9427980
http://www.ncbi.nlm.nih.gov/pubmed/10674181
http://www.ncbi.nlm.nih.gov/pubmed/2138506



2. CAFFEINE
http://www.ncbi.nlm.nih.gov/pubmed/17396054
http://www.ncbi.nlm.nih.gov/pubmed/18070215
http://www.ncbi.nlm.nih.gov/pubmed/10332073

2.1 Sunscreen effects (caffeine)
http://www.ncbi.nlm.nih.gov/pubmed/16864596

2.2 Skin cancer (caffeine)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129466/
http://www.ncbi.nlm.nih.gov/pubmed/25591953
http://www.ncbi.nlm.nih.gov/pubmed/21505179
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353410/
http://www.ncbi.nlm.nih.gov/pubmed/18179623
http://www.ncbi.nlm.nih.gov/pubmed/17388926
http://www.ncbi.nlm.nih.gov/pubmed/12570332
http://www.ncbi.nlm.nih.gov/pubmed/12392153

2.3 Other skin conditions (caffeine)
http://www.ncbi.nlm.nih.gov/pubmed/11712038
http://www.ncbi.nlm.nih.gov/pubmed/8740461
http://www.ncbi.nlm.nih.gov/pubmed/17214716
http://www.ncbi.nlm.nih.gov/pubmed/25382163
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500065/
http://www.ncbi.nlm.nih.gov/pubmed/24704471
http://www.ncbi.nlm.nih.gov/pubmed/21179241
http://www.ncbi.nlm.nih.gov/pubmed/16249145
http://www.ncbi.nlm.nih.gov/pubmed/9809669


3. ASPIRIN
http://www.ncbi.nlm.nih.gov/pubmed/20950260
http://www.ncbi.nlm.nih.gov/pubmed/16949225
http://www.ncbi.nlm.nih.gov/pubmed/8339418
http://www.ncbi.nlm.nih.gov/pubmed/12013195
http://www.ncbi.nlm.nih.gov/pubmed/9059677

I've been using the Niacinamide/Caffeine combo for a few weeks. Nothing to report yet, but +1 for niacinamide for making my face skin silky smooth

Iuyy, First, I'd like to thank you for your excellent contributions to the site. On the other hand, where are your results? You always back this stuff up. I want to see it.

as in pictures ?

Yes, I haven't as my regimen and experimentation changes all the time.

I used to take a picture once a week. I will again, when I get a digital camera and settle down in London. I plan to double my work on hair loss and do even more research.

And then I will definitely provide pictures.

As in regrowth pictures? What supplements are you taking? Diet? All of peat?

okay

you asked nicely. I will start again next week, taking a picture once a week again.

2 months. 8 pictures. let's see what we can do.

yes, It is based off peat/roddy ideas yes, with a few ideas of my own.

You're actually regrowing your hair?

could be thyroid related.. i was reading this randomly the other day, funny you posted it:

http://www.raypeatforum.com/forum/viewtopic.php?t=3480

sanderson wrote:could be thyroid related.. i was reading this randomly the other day, funny you posted it:

http://www.raypeatforum.com/forum/viewtopic.php?t=3480

Actually when i had got my hair to an extremely good density I was on KI (potassium iodide). Then I was so satisfied I quit everything.

I can't do aspirin, though. It's ototoxic and it's what caused me to get tinnitus.

yes, another reason it works is it mimics T3, which is very good,

I am planning to give this as a topical trial.

Can anyone please clarify what doses of the following are required to make this topical? I plan to use the following;

Caffeine (from my instant coffee blend) - How much?
Aspirin - How much?

I will leave out the Niamicide for now...

I just plan to rub some onto the scalp in the mornings and leave in for 10 minutes or so and then rinse. How many days a week?

Thanks.

honestly, alpecin may be enough, although it has unwanted chemicals

This doesn't grow hair, though.

Aspirin resistance (Why I abhor it). Not safe for everyone.

Routine use of aspirin is even more dangerous than for younger people.  A study reported in the 
British Medical Journal May 25, 2005 shows why.  The study focused on the routine
use of aspirin in a large population of 20,000 people aged 70-74 with no vascular disease. 
The research suggests that if there are any benefits to the use of low-dose aspirin, they are offset by increased cases of serious bleeding.  

The authors of the study say the balance could tip either way, but suggest doctors should resist the temptation to implement low-dose aspirin in the elderly to prevent heart disease.  If aspirin does work, it does so
via the same protection given by omega-3 oils on an enzyme called COX (cycloxygenase). 

You've heard lots about the dangers of the cox inhibitors Vioxx and Celebrex.  Aspirin is in this same
group.  While omega-3 oils inhibit the cox enzyme, they do so without any side effects.  Also, overwhelming evidence shows, that high intake of Omega-3 is strongly associated with long life and very low cardiovascular mortality.  

More info:

Atherothrombosis accounts for 52 per cent of all deaths worldwide. This disease manifests as cardiovascular disease, ischemic heart disease and cerebrovascular disease and in the year 2000 is estimated to have claimed around 56 million people worldwide. The Centers for Disease Control has computed that the probability at birth of eventually dying from major cardiovascular diseases (47 per cent) was much higher than the probability of dying from cancer (22 per cent).

Antithrombotic drugs such as aspirin and clopidogrel are prescribed to check atherothrombosis. The American Heart Association (AHA) has recommended the use of aspirin in patients suffering from artery diseases and a second antiplatelet medicine for those with uncontrolled chest pain called unstable angina. These drugs inhibit the formation of a chemical called thromboxane A2, which is responsible for making platelets sticky and promotes blood clotting. It has been observed that the most commonly used drug--aspirin--does not show its antithrombotic activity in some patients. In this set of patients the protective effects of aspirin are not exhibited. 

Scientists at McMaster University have developed tests, which by detecting the levels of a metabolite of thromboxane in urine, can determine whether the patient is a responder or a nonresponder to aspirin therapy. This test would eliminate the guesswork and help physicians to quantify the amount of the metabolite involved in aspirin resistance. The currently used qualitative platelet function tests are subject to multiple interferences. This test would help physicians measure the patient's response to aspirin and can adjust the dose or recommend alternative platelet therapy if the patient is not responding to aspirin. 

It is very important to identify patients having aspirin resistance as studies have shown that patients taking aspirin who had a high level of thromboxane in their urine had a 3.5 times higher risk of cardiovascular death than patients who had the lowest level. By detecting high levels of 11-dehydro thromboxane B2 in urine, patients can be segregated as responders and nonresponders. In the nonresponders an alternative antiplatelet therapy can be initiated, which can more effectively block thromboxane production. This technology can assess the patient's relative risk for heart attack by measuring the patient's aspirin resistance. 

http://www.bio-medicine.org/medicine-news-1/Aspirin-Resistance-Boosts-Heart-Risks-in-Cardiac-Patients-9758-1/

CS,

As a topical in a spray bottle.

Growdamnit wrote:CS,

As a topical in a spray bottle.

Topicals get in systemically. Speaking of that, caffeine is something I used to try...I got really tired of those headaches when the wrong amount was applied.

Why do iuyy and Peat push this kind of thing, though? Is there much background to it?

http://www.alpecin.co.uk/en/research/studies/

yes, i Think it can help, but is not the solution

whatever i recommend, people will say snake oil

you decide if this makes sense or not

i think the big kicker with aspirin and peat is that he recommends vit K with it, doesn't he?

i'm going to be adding this to my regimen. i recently added coffee and feel a world of difference. deep voice, better clarity, more "in tune" with the world.

iuyyighghghgkh any idea of dosing that you had success with? and the vit K is required as well, isnt it?

you should tkae vitamin k2 anyway,

but yes, if you do aspirin too

600mg per 60ml,

There seems to be a lot of hype circulating about caffeine and aspirin applied topically to the scalp. In some articles, there are really bold claims. I am not sure either way, but am willing to give this a try. Not with the expectation that it is a cure, but that it may be of assistance.

Here is what I am planning;

1. - Mixing two soluble aspirin tablets in about 2-3oz of water
2. - Mixing approx 2 heaped teaspoons of caffeine into 2-3oz of water.
3. - Mixing both together and then applying and letting sit on scalp for at least 15mins. I may or may not rinse.

Does anyone have any thoughts on this? Should this be done once or twice a week?

Thanks.