Hair Growth–Promoting Effects of Adiponectin In Vitro

Journal of Investigative Dermatology , (28 June 2012)
Hair Growth–Promoting Effects of Adiponectin In Vitro

There is no abstract for this, so will make my own.

Adipocytes are pivotal for metabolic regulation. Activation of PPARγ nuclear receptors leads to increased storage of fat in adipocytes. Adiponectin is a factor (an adipokine) that is required for hair growth--that is maintaining normal lipid metabolism.

Promotion of adiponectin can result in reduced circulating lipids and ectopically stored fat, leading to increased insulin sensitivity.

A number of natural agents, such as curcumin and EGCG (Green tea) are known to promote hair growth and also activate PPARγ. This increases adiponectin, and other research performed in vivo confirm this.

Nice CS, thank you.

Berberine regulates peroxisome proliferator-activated receptors and positive transcription elongation factor b expression in diabetic adipocytes.
Zhou J, Zhou S.

Source
Base for Drug Clinical Trial, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, PR China.

Abstract
Berberine has hypoglycemic and hypolipidemic effects on diabetic rats. This study investigated the relationship between hypoglycemic and hypolipidemic effects of berberine and peroxisome proliferator-activated receptors (PPARs) and positive transcription elongation factor b (P-TEFb) (including cyclin-dependent kinase 9 (CDK9) and cyclin T1) in white adipose tissue of diabetic rats and RNA interference-treated 3T3-L1 cells. Berberine promoted differentiation and inhibited lipid accumulation of 3T3-L1 cells, further decreased PPARα/δ/γ, CDK9 and cyclin T1 mRNA and protein expression and decreased tumor necrosis factor α content in supernatants of both control and RNA interference-treated 3T3-L1 cells. After a 16-week induction with 35 mg/kg streptozotocin (i.p.) and high-carbohydrate/high-fat diet, diabetic rats were treated with 75, 150 and 300 mg/kg berberine and 100 mg/kg fenofibrate or 4 mg/kg rosiglitazone for another 16 weeks. Berberine decreased white adipose tissue to body weight ratio and adipocyte size and increased adipocyte number. Berberine upregulated PPARα/δ/γ, CDK9 and cyclin T1 mRNA and protein expression in adipose tissue, decreased tumor necrosis factor α and free fatty acid content and increased lipoprotein lipase activity in serum and adipose tissue. Berberine modulated metabolic related PPARs expression and differentiation related P-TEFb expression in adipocytes, which are associated with its hypoglycemic and hypolipidemic effects.

Thanks for that study CS.