Burden of infection on Insulin Resistance, Metabolic Syndrome, Thyroid, Stress, and Inflammation

Recent and historical evidence is consistent with the view that atherosclerosis is an infectious disease or microbial toxicosis impacted by genetics and behavior. Because small bacterial-like particles, also known as nanobacteria have been detected in kidney stones, kidney and liver cyst fluids, and can form a calcium apatite coat we posited that this agent is present in calcified human atherosclerotic plaques. Carotid and aortic atherosclerotic plaques and blood samples collected at autopsy were examined for nanobacteria-like structures by light microscopy (hematoxylin-eosin and a calcium-specific von Kossa staining), immuno-gold labeling for transmission electron microscopy (TEM) for specific nanobacterial antigens, and propagation from homogenized, filtered specimens in culture medium. Nanobacterial antigens were identified in situ by immuno-TEM in 9 of 14 plaque specimens, but none of the normal carotid or aortic tissue (5 specimens). Nanobacteria-like particles were propagated from 26 of 42 sclerotic aorta and carotid samples and were confirmed by dot immunoblot, light microscopy and TEM. [3H]L-aspartic acid was incorporated into high molecular weight compounds of demineralized particles. PCR amplification of 16S rDNA sequences from the particles was unsuccessful by traditional protocols. Identification of nanobacteria-like particles at the lesion supports, but does not by itself prove the hypothesis that these agents contribute to the pathogenesis of atherosclerosis, especially vascular calcifications.

If you take simvastatin to control cholesterol, watch out for infection says new( re)port
New research published in the Journal of Leukocyte Biology suggests that simvastatin negatively impacts the immune system's ability to clear infection and control inflammation in the presence of bacteria

Simvastatin might help us control our cholesterol, but when it comes to infection, it's an entirely different story says a new research study published in the Journal of Leukocyte Biology (http://www.jleukbio.org). In the research report, scientists from Italy show that simvastatin delivers a one-two punch to the immune system. First it impairs the ability of specialized immune cells, called macrophages, to kill pathogens. Then, it enhances production of molecules, called cytokines, which trigger and sustain inflammation.

"Statins are key drugs in the primary and secondary prevention of cardiovascular disease," said Cosima T. Baldari, Ph.D., a scientist from the Department of Evolutionary Biology at the University of Siena in Siena, Italy, who was involved in the research. "Our understanding of how these drugs affect the immune system should help maximize the benefits of these excellent drugs."

To make this discovery, the researchers conducted experiments using human cells and then followed up by conducting additional experiments in mice. They used human macrophages derived from blood samples of healthy donors and murine (mouse) macrophages. The macrophages were incubated with Staphlococcus aureus, a pathogen commonly found on the skin and in the upper airways. Once the infection manifested, researchers analyzed the bactericidal response of macrophages treated with simvastatin. Results showed that the treated macrophages were significantly impaired in both the removal of the pathogen and related cell debris and the killing of ingested bacteria compared to untreated cells. Additionally, the treated cells produced higher amounts of cytokines, which are responsible for triggering and sustaining inflammation. The same experiment was conducted in vivo, using mouse models, with similar results.

There is a substantial amount of evidence that relatively low cholesterol levels in apparently healthy individuals is associated with increased subsequent mortality from cancer. It is also associated with other, non-heart related deaths. A group at the Center for Clinical Pharmacology, University of Pittsburgh, Pennsylvania, tested whether the effectiveness of their immune systems differed in individuals with high and low levels of blood cholesterol.[i] The low cholesterol group's cholesterol averaged 3.9 mmol/L (151 mg/dL); the high cholesterol group averaged 6.8 mmol/L (261 mg/dL). The immune systems of the men in the low cholesterol group were significantly less effective than those of the high cholesterol group. This finding was not surprising as several studies have shown that cholesterol is necessary for the proper functioning of blood cells — macrophages and lymphocytes — that form part of our immune systems. For this reason low blood cholesterol undoubtedly adversely affects our bodies' ability to fight infection. This could well be another reason why infectious diseases are becoming more prevalent in our society.

Tuberculosis (TB), a disease thought to have been conquered decades ago, is returning. It has been noticed that low levels of cholesterol are common in patients suffering from TB. TB patients with low cholesterol also have higher death rates, particularly those cases with small (military) nodules. A hospital for respiratory diseases tested whether giving TB patients high-cholesterol meals would be effective in treating their condition.[ii] They split patients into two groups. One had meals containing 800 mg of cholesterol per day; the other had 250 mg of cholesterol per day. The trial was a success. By the second week, the numbers of TB bacteria in sputum was reduced 80% in the high-cholesterol group; it was only reduced by 9% in the low-cholesterol group. High-cholesterol diets now form part of the treatment for TB.

B. burgdorferi is one of the few pathogenic bacteria that can survive without iron, having replaced all of its iron-sulfur cluster enzymes with enzymes that use manganese, thus avoiding the problem many pathogenic bacteria face in acquiring iron.

jdp701 wrote:

B. burgdorferi is one of the few pathogenic bacteria that can survive without iron, having replaced all of its iron-sulfur cluster enzymes with enzymes that use manganese, thus avoiding the problem many pathogenic bacteria face in acquiring iron.

jdp701 wrote:Goes along with my other rants about dangers of iron (i.e. insulin resistance, increased bacterial and fungal issues, etc.). Also shows why you find borrelias/lyme in childhood ailments.

jdp701 wrote:I don't recommend iron supplement at all. If someone is anemic and believes it's due to low iron, in most cases IP6 clears that right up.... rust.

Regarding iron and zinc, it's actually copper and zinc. Don't ever take a zinc supplement without the added copper if mercury toxic.

hope this helps

Hoppipolla wrote:Hiya, I think I can get a bit more stuck in here now as I understand much more and also think my hair loss may have a connection to pathogens too.

So, how many people are on Rife now then? I've just been doing some crude "zapping" with a 9v battery (the tapping technique, which mimics a Hulda Clark style zapper at around 5-10hz) but would love to gradually move up to something closer to a full Rife machine (I believe I actually understand how to make one, at least mostly).

But yeah erm, just wanted to get back into this thread and have a chat, as I'm still learning more every day

Hoppi

from:
http://www.ncbi.nlm.nih.gov/pubmed/8686573


The authors found that antibiotics used to treat various infections often were ineffective in the presence of abnormal localized deposits of heavy metals like Hg and Pb, which were often observed to co-exist with Chlamydia trachomatis, Herpes Simplex Types I & II, Cytomegalovirus(CMV), and other micro-organisms. Our earlier research revealed that despite rigorous treatment with antibiotics together with various drug uptake enhancement techniques, subjects who had been treated for Chlamydia trachomatis infections, seemingly successfully with disappearance of their symptoms, were often experiencing recurrences within several months after completion of their treatment despite taking precautions against reinfection. Careful examination of the entire body of these symptom-free patients with the Bi-Digital O-Ring Test revealed that the Chlamydia trachomatis had retreated to 3 approximately 5 hiding places with localized increase in uric acid levels: 1) sublingual caruncle, 2) a small round area in the right and/or left axillae, 3) the genitals (Corona Glandis area of the Glans Penis at the Fossa Navicularis of the urethra in the male, and near the orifice of the urethra in the female), 4) Insulin-like Growth Factor positive horizontal lines, particularly above and below the knees, 5) the maxillary, ethmoid and frontal sinuses and the horizontal lines at the base of the nostrils (particularly small areas where Insulin-like Growth Factors exist). We found that all these areas contain Insulin-like Growth Factors I & II which are reduced in the presence of infection. Even when drug uptake of antibiotics was selectively increased in these 3 approximately 5 areas by various drug uptake enhancement methods developed by the 1st author, still the infection persisted. In the spring of 1995, use of Chinese parsley for successful elimination of Hg deposits existing in various organs of the first author as the result of the decay of radioactive Thallium 201 injected for cardiac SPECT, was accidentally discovered after eating Vietnamese soup, which happened to contain Chinese parsley, also called cilantro. We also found Chinese parsley accelerates the excretion of Hg, Pb, and A1 from the body though the urine. Our subjects were given a course of antibiotics (Doxycycline for Chlamydia trachomatis infection) or anti-viral agents (EPA with DHA for Herpes Family Viruses) together with Chinese parsley. Since these vegetable/herbs were eaten, the amount of effective substance absorbed varied and some people did not like the taste of these relatively large amounts of either cooked or raw parsley or its juice, but together with effective antibiotics delivered by drug uptake enhancement methods to the infected areas, the substances worked synergistically, rapidly reducing the generalized symptoms and infection. The micro-organisms retreated to the 3 approximately 5 areas listed above where, with continued treatment, they were significantly reduced, but not completely eliminated. Because of these problems, a pharmaceutical company was asked to produce a Chinese parsley table containing a controlled amount in a highly absorbable form. When 11 subjects were treated with Doxycycline for Chlamydia trachomatis infection, or anti-viral agents (EPA with DHA) for Herpes Family Viruses, drug uptake enhancement methods to selectively increase delivery of the drugs to the affected areas, and Chinese parsley tablets to remove the heavy metal deposits, the last traces of the infections and clinical symptoms disappeared completely. Therefore we hypothesized that the infectious micro-organisms mentioned above, somehow utilize the Hg or Pb to protect themselves from what would otherwise be effective antibiotics, and/or that heavy metal deposits in some way make antibiotics ineffective. Since the micro-organisms retreat to areas in which Insulin-like Growth Factors I & II normally exist, they may be utilizing them for their own growth and multiplication.

Modulation of nutrient metabolism and homeostasis by the immune system

* Article author query
* humphrey bd [PubMed] [Google Scholar]
* klasing kc [PubMed] [Google Scholar]

B.D. Humphreya1 and K.C. Klasinga1 c1

a1 Department of Animal Science, University of California, 1 Shields Ave., Davis, CA, USA

Abstract

Interactions between nutrition and immunity are diverse and have profound implications on animal growth and productivity. The innate immune system provides protection during the initial stages of infection and is responsible for mediating many of the alterations in nutrient metabolism. The macrophage is the key sensory and regulatory cell of the innate immune system. Their pro-inflammatory cytokines coordinate local immunity to pathogens, yet also act systemically to alter metabolic homeostasis and decrease food intake and growth rate. Altered energy, amino acid, lipid, and mineral metabolism have nutritionally important implications. For example, an innate immune response results in decreased uptake of amino acids by skeletal muscles and a corresponding increase in uptake by the liver and to a lesser extent by leukocytes. The net result is a decrease in amino acid requirements with no change in the efficiency of their use for growth. The shift in the priority of individual tissues for nutrients appears to be accomplished by changes in the types and amounts of their nutrient transporters and storage proteins. Adaptive immune responses result in considerably more subtle changes in nutrient metabolism than innate responses.