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L-Cysteine & N-Acetyl-L Cysteine
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L-Cysteine & N-Acetyl-L Cysteine
Hi guys
I wanted to know what is the difference between L-Cysteine and N-Acetyl-L Cysteine
Thanks in advance!
I wanted to know what is the difference between L-Cysteine and N-Acetyl-L Cysteine
Thanks in advance!
FireFist- Posts : 315
Join date : 2010-07-22
Re: L-Cysteine & N-Acetyl-L Cysteine
I was under the impression that it had to do with improved oral bioavailability, but I could be wrong. I'm trying to find the source where I read that.
Either way, there's a ton of evidence supporting oral NAC supplementation.
Either way, there's a ton of evidence supporting oral NAC supplementation.
crincrin- Posts : 358
Join date : 2010-04-15
Re: L-Cysteine & N-Acetyl-L Cysteine
http://jas.fass.org/cgi/reprint/jas.2006-835v1
dietary supplementation of Cys is complicated because its free
38 sulfhydryl group is capable of spontaneous oxidation, resulting in product instability.
39 Moreover, the oxidized form, cystine (Cys-Cys), is relatively insoluble, making both
40 forms poor candidates for enteral or parenteral nutrition formulas. Recent studies suggest
41 excess dietary Cys may be deleterious to animal growth and feed consumption in various
42 species (Dilger et al., 2007). Therefore, safe and functional alternative Cys precursor
43 products have been sought.
44 N-Acetyl-L-cysteine (NAC) serves as a precursor for Cys because the -amino
45 nitrogen is protected by an acetyl group, and most tissues in the animal body possess the
46 ability to remove this acetyl group and, thus, furnish Cys. For this reason, NAC has been
47 extensively studied as both a therapeutic agent and direct Cys precursor.
crincrin- Posts : 358
Join date : 2010-04-15
Re: L-Cysteine & N-Acetyl-L Cysteine
That's not completely satisfying. I can't find an original source that shows limited bioavailability of oral cysteine.
crincrin- Posts : 358
Join date : 2010-04-15
Re: L-Cysteine & N-Acetyl-L Cysteine
hi crincrin
Thanks for i have no idea what you just said, lol
are they basically the same substance only in different forms?
Thanks for i have no idea what you just said, lol
are they basically the same substance only in different forms?
FireFist- Posts : 315
Join date : 2010-07-22
Re: L-Cysteine & N-Acetyl-L Cysteine
Haha ok, basically, cysteine will not make it into the blood stream without reacting with other substances (it's unstable and becomes unusable). Basically, adding an acetyl group (turning cysteine into N-Acetylcysteine), stabilizes the molecule so that it doesn't react with other things.
Once in the bloodstream, cysteine and NAC are not the same thing. But the point is to raise glutathione levels, and NAC seems to be able do that. Cysteine is a precursor for glutathione; NAC replaces cysteine in some surrounding molecules, releasing the cysteine for glutathione production.
Long story short: NAC is better absorbed than cysteine. It doesn't work exactly the same way, but it has the same net effect of raising glutathione.
Once in the bloodstream, cysteine and NAC are not the same thing. But the point is to raise glutathione levels, and NAC seems to be able do that. Cysteine is a precursor for glutathione; NAC replaces cysteine in some surrounding molecules, releasing the cysteine for glutathione production.
Long story short: NAC is better absorbed than cysteine. It doesn't work exactly the same way, but it has the same net effect of raising glutathione.
crincrin- Posts : 358
Join date : 2010-04-15
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