Immortal Hair
Would you like to react to this message? Create an account in a few clicks or log in to continue.

Search
 
 

Display results as :
 


Rechercher Advanced Search

Check Out Our Sponsors
Brought to you by
Hair Loss Forum
Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search
Latest topics
» seed oils and colon cancer
Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells EmptyToday at 8:27 am by CausticSymmetry

» *The first scientific evidence in 2021 that viruses do not exist*
Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells EmptyToday at 4:06 am by shaftless

» ever hear of ayahuasca?
Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells EmptyMon Dec 09, 2024 2:13 am by calvicie

» Congo illness
Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells EmptySun Dec 08, 2024 8:17 am by CausticSymmetry

» Experimental aftermath.
Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells EmptyWed Dec 04, 2024 3:38 am by CausticSymmetry

» growing and development of hairline in infants
Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells EmptyMon Dec 02, 2024 8:42 am by CausticSymmetry

» Is this beneficial bacterial strain the Pièce de résistance?
Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells EmptySat Nov 30, 2024 9:32 am by CausticSymmetry

» Roles of gut microbiota in androgenetic alopecia: insights from Mendelian randomization analysis
Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells EmptySun Nov 24, 2024 4:22 pm by CausticSymmetry

» Urolithin A
Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells EmptySun Nov 24, 2024 4:32 am by CausticSymmetry

Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search

Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells

2 posters

Go down

Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells Empty Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells

Post  CausticSymmetry Fri Jun 28, 2024 8:03 am

J Microbiol Biotechnol. 2024 Apr 28;34(4):812-827. doi: 10.4014/jmb.2311.11047. Epub 2024 Mar 8.
Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells

Seokmuk Park 1, Ye Jin Lim 1, Hee Su Kim 1, Hee-Jae Shin 1, Ji-Seon Kim 1, Jae Nam Lee 2, Jae Ho Lee 1, Seunghee
Phloroglucinol (PG) is one of the abundant isomeric benzenetriols in brown algae. Due to its polyphenolic structure, PG exhibits various biological activities. However, the impact of PG on anagen signaling and oxidative stress in human dermal papilla cells (HDPCs) is unknown. In this study, we investigated the therapeutic potential of PG for improving hair loss. A non-cytotoxic concentration of PG increased anagen-inductive genes and transcriptional activities of β-Catenin. Since several anagen-inductive genes are regulated by β-Catenin, further experiments were performed to elucidate the molecular mechanism by which PG upregulates anagen signaling. Various biochemical analyses revealed that PG upregulated β-Catenin signaling without affecting the expression of Wnt. In particular, PG elevated the phosphorylation of protein kinase B (AKT), leading to an increase in the inhibitory phosphorylation of glycogen synthase kinase 3 beta (GSK3β) at serine 9. Treatment with the selective phosphoinositide 3-kinase/AKT inhibitor, LY294002, restored the increased AKT/GSK3β/β-Catenin signaling and anagen-inductive proteins induced by PG. Moreover, conditioned medium from PG-treated HDPCs promoted the proliferation and migration of human epidermal keratinocytes via the AKT signaling pathway. Subsequently, we assessed the antioxidant activities of PG. PG ameliorated the elevated oxidative stress markers and improved the decreased anagen signaling in hydrogen peroxide (H2O2)-induced HDPCs. The senescence-associated β-galactosidase staining assay also demonstrated that the antioxidant abilities of PG effectively mitigated H2O2-induced senescence. Overall, these results indicate that PG potentially enhances anagen signaling and improves oxidative stress-induced cellular damage in HDPCs. Therefore, PG can be employed as a novel therapeutic component to ameliorate hair loss symptoms.

Keywords: Human dermal papilla cells (HDPCs); Phloroglucinol; hair growth; hair loss; oxidative stress; protein kinase B (AKT).

Long form: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11091678/

_________________
My regimen
http://www.immortalhair.org/mpb-regimen
(Primary site under construction: )

Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation

Primary site under construction:
https://immortalhair.org/

Archived as of 2022 here:
https://web.archive.org/web/20220330061828/https://www.immortalhair.org/
CausticSymmetry
CausticSymmetry
Admin

Posts : 14390
Join date : 2008-07-09

http://www.immortalhair.org/

Back to top Go down

Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells Empty Re: Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells

Post  CausticSymmetry Fri Jun 28, 2024 8:06 am

Of note, Ecklonia cava (ECE), a type of brown seaweed, does contain phloroglucinol. In the polyphenolic (phlorotannin) fraction of Ecklonia cava, which constitutes up to 18.3% of its dry weight, phloroglucinol is present as the simplest phlorotannin structure.

_________________
My regimen
http://www.immortalhair.org/mpb-regimen
(Primary site under construction: )

Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation

Primary site under construction:
https://immortalhair.org/

Archived as of 2022 here:
https://web.archive.org/web/20220330061828/https://www.immortalhair.org/
CausticSymmetry
CausticSymmetry
Admin

Posts : 14390
Join date : 2008-07-09

http://www.immortalhair.org/

Zaphod likes this post

Back to top Go down

Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells Empty Re: Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells

Post  shaftless Fri Jun 28, 2024 3:49 pm

I wonder if its possible to duplicate the same concentrations as these lab experiments

shaftless

Posts : 1414
Join date : 2012-08-12

Back to top Go down

Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells Empty Re: Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells

Post  Sponsored content


Sponsored content


Back to top Go down

Back to top

- Similar topics

 
Permissions in this forum:
You cannot reply to topics in this forum