Stem Cell Hair Transplants

Its seems Stem Cell Hair Transplants are already available.

I have seen common terms being used for different treatments and one can falsely think they are all the same.

1-One is when where stem cells are harvested from fat tissue. Then it is injected into to scalp to regenerate the area.

2-Another one is when hair follicles and stem cells are removed from the donor area in the back of the head.

3-But there is I believe a third one, which is the most promising one, where a stem cell can be taken from any part of the body, doesn't necessarily have to be from the head, nor fat, and then using cloning, the hair follicles are multiplied. Once the necessary amount of hair follicles have been replicated, they are injected into the scalp.

I don't like number 1 because I've heard this is not a very easy process to do. And I don't like number 2 either because it basically reduces the hair follicles from the donor area, not to mention potentially leaving a scar.

However, in terms of number 3, this is the best one. Question is, has it become available?

So here's the deal....does it work? Yes.

Is it available? No and sort of yes.....There's the Fraud & Death Administration (FDA)...
But to be objective here, research on stem cell hair transplants is still in its infancy.

Some clinics offer stem cell hair replacement treatments, but they are still considered clinical trials and are not 'approved' by the FDA.

The embryonic stem cells are probably the concern with the Fraud & Death Administration and this is the number 3 category

In my opinion, based on my own research for clients....it's safe...however some clinicians will raise red flags such as 'cancer' potential, which in my opinion is a red herring, and to be fair, these "researchers" have bought into the idea of certain constructs which are purely hypothetical and not based on rigorous scientific principles.

Embryonic stem cells make some clinicians nervous because, because they have this notion that it increases cancer risk and that is a liability that do not want anything to do with...unless of course their almighty "gawd" Fraud & Death Administration gives it the thumbs up.

An aside here, real cancer risk comes from Quackination (it's the Nagalase enzyme)....

Nagalase is an enzyme produced by cancer cells. It is used to break down certain sugars, such as Gc protein-derived macrophage-activating factor (GcMAF), which is required for the body to naturally fight cancer and infections. By blocking the production of GcMAF, Nagalase can make it harder for the body to fight these diseases...because it blocks the use of vitamin D from working.

Alpha-N-Acetylgalactosaminidase (α-Nagalase) is often found in quackcines probably because in part, they use
immortalized cell lines.

These are cell lines that have been altered to divide indefinitely. And the ridiculous idea is that they are used to 'grow' viruses (which do not exist)...so this is the "why" of what Quackcines contain this stuff.

Anyway stem cells and/or embryonic stem cells are safe when they are pure....so generally they are called Pluripotent stem cells and are capable of differentiating into any type of cell in the body.

So there are some work-around ways to get this treatment.....fly to an island that doesn't care about FDA, draconian regulation limitations or....

Stem cell hair treatment clinical trials offer an alternative for people who are not candidates for current hair loss treatments.

Statistical methods
The primary outcomes were obtained by microscopic identification and counting of HFSCs. The secondary outcomes were clinical preliminary results and safety and feasibility in HFSCs-treated scalp.

The primary outcomes were obtained by microscopic identification and counting of HFSCs. The mean total number of HFSCs in each scalp tissue suspension was 3,728.5±664.5 cells. The mean percentages of positive cells for CD44 and CD200 were 5%+0.7% and 2.6%+0.3%, respectively.

The secondary outcomes were clinical preliminary results and safety and feasibility in HFSCs-treated scalp. In total, 23 weeks after the last treatment with HFSCs, mean hair count and hair density increases over baseline values were observed. In particular, a 29%±5% increase in hair density for the treated area and less than a 1% increase in hair density for the placebo area were observed. The hair density increases were greater in the frontal and temporal regions compared to the parietal and occipital regions.

No adverse events

Thanks for that detailed description CS. That was very informative.

I'm still continuing in my search to find the best place to do this.

As I said, many clinics are using the word Stem Cell but not all are the same.

It seems like I need to narrow down my search to "stem cell hair replacement treatments" and "embryonic stem cells". Is that right?

One is called Regenera Activa, but upon a closer look, it looks like they aren't replicating any hair stem cell follicles.

I've also seen one referred to as Stem Cell Micrograft Hair Transplant. But than on a closer look this also wasn't the one I'm looking for. The one I'm looking is minimally invasive. Requires no invasive removal of follicles from the back of the head nor does it require fat removal. I think I read somewhere that it's even possible by withdrawing blood and perhaps a single hair follicle.

Please DM if you know some clinics you recommend that do the Stem Cell treatment I'm trying to find.

MikeGore wrote:Thanks for that detailed description CS. That was very informative.

I'm still continuing in my search to find the best place to do this.

As I said, many clinics are using the word Stem Cell but not all are the same.

It seems like I need to narrow down my search to "stem cell hair replacement treatments" and "embryonic stem cells". Is that right?

One is called Regenera Activa, but upon a closer look, it looks like they aren't replicating any hair stem cell follicles.

I've also seen one referred to as Stem Cell Micrograft Hair Transplant. But than on a closer look this also wasn't the one I'm looking for. The one I'm looking is minimally invasive. Requires no invasive removal of follicles from the back of the head nor does it require fat removal. I think I read somewhere that it's even possible by withdrawing blood and perhaps a single hair follicle.

Please DM if you know some clinics you recommend that do the Stem Cell treatment I'm trying to find.

search offshore, like Panama

I think I've found one. It seems like there's an application process. Need to save up on money to get this done and a time to travel.

Given that I am seeing slick bald areas in my scalp, I'm losing hope so a stem cell hair replacement treatment is becoming my only option it seems.

Unless there is a way to make hair grow in areas that there is no hair.

I see that there are products selling HFSC to be applied as a topical. Doesn't make sense to me that topical application will regrow hair in slick bald areas. Or perhaps a laser and HFSC topical application.

Hair Stem Cell Transplantation (HST)
HST Method - How It's Done

HST uses the power of nature by drawing on the capacity for regeneration of human stem cells. What is unique about this innovative technique is that only a small part of the hair follicle – instead of the entire follicle – is harvested from the donor area.

This tiny little piece of tissue contains enough stem cells to grow new hair in the receptor area. This is a small miracle: this regenerative capacity can result in multiple hairs from one single graft (hair follicle). The new grafts (hair follicles) are placed closely together, which creates high hair density and a beautiful, natural looking hairline. A special, patented preservation solution stimulates growth and increases the viability of the grafts by giving them an extra boost. This integrated approach is the basis of our sophisticated hair transplantation method which promotes the growth of hair in the receptor area and donor area.

Explanation of the HST hair transplant technique

One follicle, multiple hairs
This tiny little piece of tissue contains enough stem cells to grow new hair in the receptor area, and can result in multiple hairs from one single graft (hair follicle). The new grafts are placed closely together, which creates high hair density and a beautiful, natural-looking hairline.






"To demonstrate that the population of follicular stem cells consists of pluripotent, multipotent, oligopotent and unipotent stem cells and that these stem cells may be stimulated to generate fully differentiated hairs. Therefore it would not be necessary to transplant the whole hair follicle to regenerate new hairs, but only (a part of) the follicular stem cells. In the investigations described in this thesis, we investigate the characteristics of different follicular stem cells and their potential applications."
https://repub.eur.nl/pub/116494/

Question:
I've across this treatment here and it looks pretty good. I have one question though and I hope someone informed can help me understand.

Ever since I first heard of stem cells hair treatment, I thought it was the revolutionary one off treatment I am waiting for.

But then, as I mentioned in the first post in this thread, I found a lot of other things that are called stem cells hair loss treatment, but it was not related to hair cloning which meant donor area would lose a lot of hair and it didn't guarantee results.

What I disliked about the hair transplants the most is I often would read things such as, the hair wouldn't grow or it wouldn't look natural.

What upset me the most was that the donor area would lose hair follicles and the implanted hair would not look natural. So I thought, the best method surely would be hair cloning so we don't lose from the donor area and the one follicle is just replicated as much as needed. I also felt that hair follicle that is cloned and implanted would be more natural looking hair.

So now I have come across this clinic. They say they use a method called Partial Longitudinal Follicular Unit Transplantation (PL-FUT) technique, with the simpler name Hair Stem Cell Transplantation (HST).

I know there is another older method called FUT, which I don't know much about but never thought highly of it for some reason. I am hoping this PL-FUT technique is much better.

The Question:

• if they are getting one hair and able to multiply it, how is this method different from the hair cloning method that is still not available(except for the clinical trials)?
  

• what is the point of waiting for the hair cloning(which super-expensive), if with the PL-FUT method they are multiplying a single hair follicle that is basically the same as hair cloning no? Seems like it is the same thing.
  

Any clarification would be welcome.

MikeGore wrote:Thanks for that detailed description CS. That was very informative.

I'm still continuing in my search to find the best place to do this.

As I said, many clinics are using the word Stem Cell but not all are the same.

It seems like I need to narrow down my search to "stem cell hair replacement treatments" and "embryonic stem cells". Is that right?

One is called Regenera Activa, but upon a closer look, it looks like they aren't replicating any hair stem cell follicles.

I've also seen one referred to as Stem Cell Micrograft Hair Transplant. But than on a closer look this also wasn't the one I'm looking for. The one I'm looking is minimally invasive. Requires no invasive removal of follicles from the back of the head nor does it require fat removal. I think I read somewhere that it's even possible by withdrawing blood and perhaps a single hair follicle.

Please DM if you know some clinics you recommend that do the Stem Cell treatment I'm trying to find.

I'm starting to see lots of ads of "stem cell hair treatment" in Turkey, which emphasize "stem cell" part but don't give much details about the rest. I have no idea how legit they are though. I always thought these were just scam because a working stem cell hair treatment would probably be ground breaking and we'd hear it on the news I think.

I'm coming to the point of seriously considering hair transplants.

Even though I believe the nutritional and life style approach is very important, I think it is only useful in terms of prevention. Once it's gone, it is incredibly difficult to get it back.

I'm so depressed I sometimes consider ending my life. It can be a terrible thing, for decades looking at the mirror, hoping for any growth, and it hardly happens.

If hair regrowth on balding areas can be guaranteed, whatever it is, I would do it.

I've even got these microneedling pens Dr. Pen, and together with numbing cream, wound myself all red and bleeding, hoping for regrowth. I still intend to do this as I haven't fully given up yet, but it's looking like I need a hair transplant. And I know nothing about hair transplants because I've always looked at it negatively. But I need a solution because I can't continue to live like this. It really pisses me off that I have this disease. I see tons of people with amazing hair everyday and they don't need to go through this shit.

But if I am to do hair transplant where do I start? I hear terms like FUT, FUE, then there are FUT-DHI etc and many more and don't know which is better. Then they talk about leaving a scar. I hear there are clinics using robot during the procedure. Is this better? Are the scars big?

I need to find the best one, which means, the most natural, the one that doesn't leave visible scars. People always talk about doing hair transplant in Turkey. Where in Turkey is the best?

I was just reading this:

"Migration of stem cells from one niche to another is a fundamental behavior observed during tissue morphogenesis, homeostasis, and repair 1. A common thread running throughout these phenomena is the ability of stem cells to sense their environmental cues that, in turn, regulate their spatiotemporal localization with amazing precision. Perturbations of such cellular responses underlie a spectrum of pathologies ranging from developmental defects, tumor metastasis and ineffective wound closure 2,3. In somatic tissues, the wound-healing process is a paradigm of the directed migration of various stem cell pools to the site of injury where they differentiate to replenish lost or damaged cells. While there has been substantial investment and progress in understanding the lineage trajectory of stem cells once they reach their destination, comparatively little is understood regarding the mechanisms guiding their chemotactic journey to the wound site. In the context of the skin, it has been shown nearly two decades ago that wounding activates various local epithelial stem cell pools, including multipotent hair follicle stem cells, to infiltrate the epidermis where they participate in the reconstruction of the damaged tissue 4,5. However, elucidation of the environmental cues that coax these cells out of their hair follicle niche to the damaged epidermis has proven to be an intractable problem to solve. Using both an excisional wound and genetic mouse models of wound healing, we discovered that wounded keratinocytes secrete the enzyme Caspase-1. This protein is classically known as a critical component of the cytosolic macromolecular complex called an inflammasome that mediates the unconventional secretion of various cytokines including IL-1a 6. Surprisingly, we find that the released caspase-1 itself has a non-canonical role in the extracellular milieu. Through the Caspase Activation Recruitment Domain (CARD) of caspase-1, this protein is sufficient to initiate chemotaxis of hair follicle stem cells into the epidermis. The secretion of caspase-1 has also been documented in many other pathological scenarios7,8 and we observed that the migration of HFSCs into the epidermis following UV irradiation of the skin is also caspase-1 dependent. Uncovering this novel function of Caspase-1 facilitates a deeper understanding of the mechanistic basis of the epithelial hyperplasia found to accompany numerous inflammatory skin diseases."

https://www.biorxiv.org/content/10.1101/548529v2.full

Does this mean that HFSC are never truly lost? And that transplanting hair follicles that contain stem cells is pointless. If I understood this abstract correctly, I guess I need to take out my Dr. Pen again. It's going to be a bloody night.

MikeGore wrote:I'm coming to the point of seriously considering hair transplants.

Even though I believe the nutritional and life style approach is very important, I think it is only useful in terms of prevention. Once it's gone, it is incredibly difficult to get it back.

I'm so depressed I sometimes consider ending my life. It can be a terrible thing, for decades looking at the mirror, hoping for any growth, and it hardly happens.

If hair regrowth on balding areas can be guaranteed, whatever it is, I would do it.

I've even got these microneedling pens Dr. Pen, and together with numbing cream, wound myself all red and bleeding, hoping for regrowth. I still intend to do this as I haven't fully given up yet, but it's looking like I need a hair transplant. And I know nothing about hair transplants because I've always looked at it negatively. But I need a solution because I can't continue to live like this. It really pisses me off that I have this disease. I see tons of people with amazing hair everyday and they don't need to go through this shit.

But if I am to do hair transplant where do I start? I hear terms like FUT, FUE, then there are FUT-DHI etc and many more and don't know which is better. Then they talk about leaving a scar. I hear there are clinics using robot during the procedure. Is this better? Are the scars big?

I need to find the best one, which means, the most natural, the one that doesn't leave visible scars. People always talk about doing hair transplant in Turkey. Where in Turkey is the best?

Ending the life is bit extreme but I get it. It is extremely depressing. You have three options. Own the balding look. Shave it off, or get a transplant. If you got money TBH transplant seems like the most viable option of the three. I've seen some youtubers actually come to Turkey for a transplant. I've also heard some good stuff, but then, they come to Turkey because it is a lot cheaper. And it is a bit weird because these guys are rich guys. They still come to Turkey.
This dude is a plastic surgeon and also does hairplants and he reacts to hairtransplant videos.


He might give you an idea. You can check out his channel for more. He is usually content with how they do it in Turkey, but he also criticizes that they use too many grafts per square inch.