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Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state
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Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state
Dev Cell . 2022 Jul 25;57(14):1758-1775.e7. doi: 10.1016/j.devcel.2022.06.005. Epub 2022 Jun 30.
Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state
Yingzi Liu 1, Christian F Guerrero-Juarez 2, Fei Xiao 3, Nitish Udupi Shettigar 4, Raul Ramos 5, Chen-Hsiang Kuan 6, Yuh-Charn Lin 7, Luis de Jesus Martinez Lomeli 8, Jung Min Park 9, Ji Won Oh 10, Ruiqi Liu 11, Sung-Jan Lin 12, Marco Tartaglia 13, Ruey-Bing Yang 14, Zhengquan Yu 11, Qing Nie 15, Ji Li 16, Maksim V Plikus 17
Hair follicle stem cells are regulated by dermal papilla fibroblasts, their principal signaling niche. Overactivation of Hedgehog signaling in the niche dramatically accelerates hair growth and induces follicle multiplication in mice. On single-cell RNA sequencing, dermal papilla fibroblasts increase heterogeneity to include new Wnt5ahigh states. Transcriptionally, mutant fibroblasts activate regulatory networks for Gli1, Alx3, Ebf1, Hoxc8, Sox18, and Zfp239. These networks jointly upregulate secreted factors for multiple hair morphogenesis and hair-growth-related pathways. Among these is non-conventional TGF-β ligand Scube3. We show that in normal mouse skin, Scube3 is expressed only in dermal papillae of growing, but not in resting follicles. SCUBE3 protein microinjection is sufficient to induce new hair growth, and pharmacological TGF-β inhibition rescues mutant hair hyper-activation phenotype. Moreover, dermal-papilla-enriched expression of SCUBE3 and its growth-activating effect are partially conserved in human scalp hair follicles. Thus, Hedgehog regulates mesenchymal niche function in the hair follicle via SCUBE3/TGF-β mechanism.
Keywords: Hedgehog pathway; Leptin receptor; Scube3; dermal papilla; fibroblasts; hair follicle; hair growth; stem cell niche.
Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state
Yingzi Liu 1, Christian F Guerrero-Juarez 2, Fei Xiao 3, Nitish Udupi Shettigar 4, Raul Ramos 5, Chen-Hsiang Kuan 6, Yuh-Charn Lin 7, Luis de Jesus Martinez Lomeli 8, Jung Min Park 9, Ji Won Oh 10, Ruiqi Liu 11, Sung-Jan Lin 12, Marco Tartaglia 13, Ruey-Bing Yang 14, Zhengquan Yu 11, Qing Nie 15, Ji Li 16, Maksim V Plikus 17
Hair follicle stem cells are regulated by dermal papilla fibroblasts, their principal signaling niche. Overactivation of Hedgehog signaling in the niche dramatically accelerates hair growth and induces follicle multiplication in mice. On single-cell RNA sequencing, dermal papilla fibroblasts increase heterogeneity to include new Wnt5ahigh states. Transcriptionally, mutant fibroblasts activate regulatory networks for Gli1, Alx3, Ebf1, Hoxc8, Sox18, and Zfp239. These networks jointly upregulate secreted factors for multiple hair morphogenesis and hair-growth-related pathways. Among these is non-conventional TGF-β ligand Scube3. We show that in normal mouse skin, Scube3 is expressed only in dermal papillae of growing, but not in resting follicles. SCUBE3 protein microinjection is sufficient to induce new hair growth, and pharmacological TGF-β inhibition rescues mutant hair hyper-activation phenotype. Moreover, dermal-papilla-enriched expression of SCUBE3 and its growth-activating effect are partially conserved in human scalp hair follicles. Thus, Hedgehog regulates mesenchymal niche function in the hair follicle via SCUBE3/TGF-β mechanism.
Keywords: Hedgehog pathway; Leptin receptor; Scube3; dermal papilla; fibroblasts; hair follicle; hair growth; stem cell niche.
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Re: Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state
So how can we get ahold of some scube3/tgf-b to make a topical and microneedle it? Are there similar compounds that resemble them? It'd be worth a try.
shaftless- Posts : 1343
Join date : 2012-08-12
Re: Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state
shaftless wrote:So how can we get ahold of some scube3/tgf-b to make a topical and microneedle it? Are there similar compounds that resemble them? It'd be worth a try.
I've looked into it, not enough info so far. Was looking for a type of agonist. But have some ideas that may or may not pan out.
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Now available for consultation (hair and/or health)
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