Vitamin K2 binds 17beta-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism

Life Sci. 2005 Apr 8;76(21):2473-82.
Vitamin K2 binds 17beta-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism.
Otsuka M, Kato N, Ichimura T, Abe S, Tanaka Y, Taniguchi H, Hoshida Y, Moriyama M, Wang Y, Shao RX, Narayan D, Muroyama R, Kanai F, Kawabe T, Isobe T, Omata M.

Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. motoootsuka-gi@umin.ac.jp

Vitamin K is a cofactor for gamma-glutamyl carboxylase, an enzyme that is important for blood coagulation. Recent studies have shown that vitamin K has other roles, in addition to post-transcriptional modification, such as bone metabolism and antitumoral actions; these findings have indicated that there might be unknown intracellular binding proteins that are specific for vitamin K. In this study, vitamin K-binding proteins were characterized by pull-down experiment using a chemically synthesized biotynylated vitamin K followed by mass spectrometric identification of the pull-downed components. The results indicated that 17beta hydroxy steroid dehydrogenase 4, apolipoportein E, and 40S ribosomal proteins S7 and S13 might be the candidates of the vitamin K-binding proteins. Subsequent experiments showed that vitamin K2 binds 17beta hydroxysteroid dehydrogenase 4 and decreases the intracellular estradiol:estrone ratio, which resulted in the inhibition of the amount of estrogen receptor alpha-binding to its target DNA. These results suggest a possible novel role for vitamin K in modulating estrogen function.

I've done a lot of research on Vitamin K2 but somehow overlooked this one.

Just a few short years, we now know that Vitamin K2 helps the regression of coronary atherosclerotic plaque, builds bone significantly and helps prevent tooth decay.

On a related note here's an article on teeth: http://nourishedmagazine.com.au/blog/articles/forgotten-tooth-decay-cure-heal-your-cavities-and-prevent-root-canals

Top nice! (Now I feel like a teenager again)

wow! so K2 can help bring down estrodial e1 e2 levels if they are too high?

Thanks for this CS! I have high estradiol and take 25mcg vit-k2 that's in with my D-3. Unfortunately this study doesn't indicate what dosage would be effective.

This brings me to a related question about calcium and mineral intake....

Other than a men's multi, the only other mineral I supp with is Mag (400-600mg/day). My question lately is if I should add any calcium or potassium. I am wondering of I am throwing the balance off by only consuming mag?

This is the 3rd best selling mag on iherb. It is mag and potassium aspartate with taurine:
http://www.iherb.com/Now-Foods-Magnesium-Potassium-Aspartate-with-Taurine-120-Capsules/701?at=0

I almost ordered this last night but decided to stick with the mag citrate that I have had no problems with thus far.

grass fed raw butter is a good source of k2

blackjack wrote:grass fed raw butter is a good source of k2

grass fed raw butter tastes great too!

too bad i cant get it in taiwan

I take one of these a day ... think it's enough CS?

http://search.lef.org/cgi-src-bin/MsmGo.exe?grab_id=0&page_id=363&query=k2&hiword=k2%20

CS... So K2 could be a safer alternativa to DIM?

Gromit137 wrote:I take one of these a day ... think it's enough CS?

http://search.lef.org/cgi-src-bin/MsmGo.exe?grab_id=0&page_id=363&query=k2&hiword=k2%20

Gromit137 - The link did not come up properly, is this one one you were asking about?

http://www.iherb.com/Life-Extension-Super-K-with-Advanced-K2-Complex-90-Softgels/14619?at=0

gonzalito - DIM is very safe, however there isn't enough research on K2 to compare them in terms of estrogen regulation. Both are anti-cancer, both inhibit MMP's (matrix metalloproteinases enzymes). K2 is important to regulate calcium homeostasis, lowers blood sugar and is more powerful than Co-Enzyme Q10, and it helpful against wrinkles. As part of my regimen I take a little K2 everyday, that's much cheaper than the life extension product.

Hopefully more research will come out because I think we've only seen the tip of the iceberg on what K2 can do.

http://www.iherb.com/Life-Extension-Super-K-with-Advanced-K2-Complex-90-Softgels/14619?at=0

Yep ... that's the one. Think one per day is enough?
Thanks.

Gromit137 - Yes

Any news concerning the dosage of vitamin K for lowering estradiol?...couldn't find any. I'm taking the recommended dose from Decalcify for the moment.

Probably the best foods for K vits are natto and chlorrella:
We found that even small quantities (10 g) of natto greatly increased by 225% (from 0.57±0.18 ng/ml to 1.28±0.46 ng/ml) vitamin K2 blood concentrations (MK-7: menaquinone-7) for a period of over 48 hours. Also, vitamin K1 concentrations increased by 152% (from 0.46±0.28 ng/ml to 0.70±0.21 ng/ml) four hours after the intake of chlorella. ...unfortunately, finding natto in Europe is not easy.

Will raising T3 work for lowering lowering estrogen and increasing progesterone (according to Ray Peat/dannyroddy, but can't find the quote right now)?

mihai wrote:Any news concerning the dosage of vitamin K for lowering estradiol?...couldn't find any. I'm taking the recommended dose from Decalcify for the moment.

Probably the best foods for K vits are natto and chlorrella:
We found that even small quantities (10 g) of natto greatly increased by 225% (from 0.57±0.18 ng/ml to 1.28±0.46 ng/ml) vitamin K2 blood concentrations (MK-7: menaquinone-7) for a period of over 48 hours. Also, vitamin K1 concentrations increased by 152% (from 0.46±0.28 ng/ml to 0.70±0.21 ng/ml) four hours after the intake of chlorella. ...unfortunately, finding natto in Europe is not easy.

Will raising T3 work for lowering lowering estrogen and increasing progesterone (according to Ray Peat/dannyroddy, but can't find the quote right now)?

Iodine will help raise T3 and iodine also helps keep estrogen at bay.

Can K2 be taken without vitamin D3? D3 is pro inflammatory for me...

CS does the decalcify product contain K2?

LawOfThelema wrote:CS does the decalcify product contain K2?

Decalcify

Servings: 90 Vegetarian Capsules

Each capsule contains...

Magnesium Orotate: 300mg
Potassium Orotate: 60mg
Zinc Orotate: 20mg
Boron Citrate: 3mg
Vitamin K2 (menaquinone-4): 5mg
Vitamin K2 (menaquinone-7): 60mcg