herpes simplex virus type 1 DNA within the beta-amyloid plaques that characterize Alzheimer's disease

The brains of Alzheimer's disease sufferers are characterized by amyloid plaques and neurofibrillary tangles. However, the cause(s) of these features and those of the disease are unknown, in sporadic cases. We previously showed that herpes simplex virus type 1 is a strong risk factor for Alzheimer's disease when in the brains of possessors of the type 4 allele of the apolipoprotein E gene (APOE-epsilon4), and that beta-amyloid, the main component of plaques, accumulates in herpes simplex virus type 1-infected cell cultures and mouse brain. The present study aimed to elucidate the relationship of the virus to plaques by determining their proximity in human brain sections. We used in situ polymerase chain reaction to detect herpes simplex virus type 1 DNA, and immunohistochemistry or thioflavin S staining to detect amyloid plaques. We discovered a striking localization of herpes simplex virus type 1 DNA within plaques: in Alzheimer's disease brains, 90% of the plaques contained the viral DNA and 72% of the DNA was associated with plaques; in aged normal brains, which contain amyloid plaques at a lower frequency, 80% of plaques contained herpes simplex virus type 1 DNA but only 24% of the viral DNA was plaque-associated (p < 0.001). We suggest that this is because in aged normal individuals, there is a lesser production and/or greater removal of beta-amyloid (Abeta), so that less of the viral DNA is seen to be associated with Abeta in the brain. Our present data, together with our finding of Abeta accumulation in herpes simplex virus type 1-infected cells and mouse brain, suggest that this virus is a major cause of amyloid plaques and hence probably a significant aetiological factor in Alzheimer's disease. They point to the usage of antiviral agents to treat the disease and possibly of vaccination to prevent it.

PMID: 18973185 [PubMed - indexed for MEDLINE]

jdp710 - Good information. It's nice to see studies like this even if they are for the purposes of "evil" like vaccines. Both iodine and Diindolylmethane inhibit HSV type I. Oh yeah, so does lithium.

Lithium flat out prevents Alzheimer's disease. Alzheimer's is probably primarily driven by thyroid disorders which is effects the mitochondria.

This study below explains how HSV eliminates host mitochondrial DNA.

http://www.nature.com/embor/journal/v8/n2/full/7400878.html

IH, would lithium orotate be used for alzheimers prevention and if so, what would you recommend as a daily dosage? Thanks man.

halfempty - About 10 milligrams of elemental Lithium (as Orotate) would work for Alzheimer's prevention.
I should point out though that most of what a lot of us are already taking will prevent Alzheimer's. Everything from Vitamin D, Curcumin, Magnesium, Essential fatty acids (omega-3 source), Lipoic acid/Acetyl L-Carnitine.

Also recently, an animal study strongly suggested that a cognitive cure for Alzheimer's would be 500 milligrams of the Niacin metabolite, Niacinamide taken 500 to 1,000 milligrams three times daily.

Thanks for the info CausticSymmetry.

... just posting interesting info on how a virus may relate to MPB

"Latent HSV-1 infections form in neuronal cells of the peripheral nervous system. When a latent infection is reactivated (by stress of many kinds), HSV-1 proteins are synthesized and new infectious virus particles are formed. These virus particles migrate along the neuronal axons to the epithelial cells of the skin. Viral growth in the skin, or other mucous membranes where nerves are found, causes cell damage and an immune reaction"

http://www.sciencedaily.com/releases/2006/06/060612184600.htm

"The virus replicates itself at the body surface,"

http://www.sciencedaily.com/releases/2009/03/090326215050.htm

"certain viruses such as HSV deplete zinc levels)"

http://www.ageofautism.com/2009/02/robert-f-kennedy-jr-and-david-kirby-on-huffpo-vaccine-court-autism-debate-continues.html

"Researchers are beginning to understand zinc's role in maintaining the structural integrity of the endothelia, which line the blood vessels, and the epithelia, which line the gastrointestinal tract. In atherosclerosis, arterial endothelial cells are destroyed by oxidating fatty acids and inflammatory immune factors. Zinc deficiency magnifies the problem. Supplementation with zinc has recently been found to protect the integrity of the blood vessel cell lining."

http://www.chiro.org/nutrition/FULL/New_Zinc_Research.shtml

jdp710 - Nice information on zinc. If I didn't eat so much meat, I'd want to ramp up my dose after reading that.

Yeah, it's definitely interesting. I've been taking zinc everyday now for about a month to help narrow down my exact cause of MPB.



I've also been taking everything imaginable for Lp (a) and I keep coming back to the same thinking that not only is Lp (a) partly responsible for my MPB but that a virus may be too.

The reason why I keep comming back to that line of thinking is that when I start take antiviral's like lysine or selenium or LLLT or to a lesser degree circumin, I start saying that I've conquered my hair loss. But when I stop taking these and only take high dose krill oil or carnitine, etc. for Lp (a), I start to get worried and I'm not as enthusiastic as I was without the antivirals.

Anyway, I was originally thinking of MPB being partly autoimmune or bacteria or fungus but none of that has panned out yet. Candida is of course a problem for MPB but I don't have a problem with that. But, maybe HSV - 1 or similiar virus. Just like this thread regarding Alzheimers and HSV -1. What's also interesting is in that thread about Brylcreem, where Brylcreem was touted as being a major reason why that guy never lost his hair ... Brylcreem contains BHT. BHT is a good antiviral agent. Using a topical antiviral agent sounds too good to be true but there is a patent on lysine and tea tree oil being used successfully to greatly speed up healing time for HSV - 2.

I just thought I'd fill anyone in if anyone is interested in trying something new.

Here's the thread on Brylcreem https://immortalhair.forumotion.com/natural-hair-regrowth-forum-f1/topical-magnesium-t596.htm

and an interesting thread I've previously posted regarding calcificiation, fibrin and viruses https://immortalhair.forumotion.com/natural-hair-regrowth-forum-f1/the-pc-microbe-t1169.htm

Also I made a couple good posts in the first part of the DKK-1 thread regarding viruses here https://immortalhair.forumotion.com/natural-hair-regrowth-forum-f1/dkk-1-enhances-inflammatory-interaction-between-platelets-and-endothelial-cells-and-shows-increased-expression-in-atherosclerosis-t1077-45.htm


But again, the Pauling protocol is simply amazing compared to other methods of reducing Lp (a). Is it because of the lysine being a very good antiviral and is used very successfuly against HSV - 1 and HSV - 2? I guess only time will tell ... I'm going to try BHT to see how well that works and a couple other antivirals. Oh, also, Vitamin D is also a very good antiviral. Another reason to make sure you get adequate sun exposure or D3.

hope this helps

Here's an interesting e-book

http://www4.dr-rath-foundation.org/pdf-files/cancer_book.pdf

Here are two quotes

"The use of high-dose lysine or lysine derivatives can slow down or halt the spread of almost every disease."

" ... practically all known disease use the collagen-dissolving mechanism to spread through the body."

Very interesting indeed...

Amazing info jdp710!

jdp710 - This is outstanding information. This really explains why Lysine supplementation is critical for vegetarians.

I was going to post a new thread on homocysteine, but I think it's more relevant here. The initial injury of the artery wall is caused by elevated blood levels of homocysteine. Taking some sources of b-vitamins and choline is important to keep homocysteine levels lower. I've been curious for years if there was a relationship with homocysteine and hair loss, but had not found any connection until associating it with lipoprotein(a). Check out this study below.

Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein(a) to fibrin: a potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism.

http://ukpmc.ac.uk/articlerender.cgi?artid=211369

Wow, nice find CausticSymmetry! I'm glad I've been focusing on homocysteine too.

I'm also been taking TMG to lower homocysteine

Here are some quotes from a good article

" Homocysteine plays a role in the entire heart disease process. It causes platelets to stick together; enhances the binding of Lp(a) to fibrin"

"There are three biochemical pathways used by the body to reduce homocysteine. In one pathway, TMG donates a methyl group which detoxifies homocysteine. In this reaction, TMG is turned into dimethylglycine (DMG) - yes, that familiar product sold as a supplement for its energizing effects. In the other routes, folic acid, B12 and B6 convert homocysteine into non-toxic substances.

Some people can't utilize one or another of these pathways. That is why a combination of all the supernutrients is the only way to guarantee that homocysteine will be lowered. Nearly all cases of elevated homocysteine can be corrected with a combination of TMG, folic acid, vitamin B12, and vitamin B6."

http://www.lef.org/magazine/mag97/july97_cover3.html

Based on my experience, there has to be a connection between a virus and MPB ... I've also been using topical lysine and other antivirals

Here's a good quote

"The herpes virus depletes Lysine in your body"

http://homehealthremedies.org/category/diagnosing/

Thx! .. interesting info

I have a couple of questions .. I thought I post it here better than a new thread ..

will I have HSV 1 IgG for few months now , I dont know much about it .. its a sore on the corner of my mouth .. and I could use any helpful informations or recommendations from you guys ..

my biggest concern is about the potential partner , is there a way I can prevent the possible conduction ? or is it inevitable ?

and whats the best way to reduce the recurring rate and if the sore reappeared what the way to handle it ?

would you kindly share ? CS ? jdp710 ?

AboDi - Take BHT (Butylated hydroxytoluene) everyday and this should be no problem.

In the past there are some info posted on this on this forum. You can find BHT on iherb

Thank You! , i'll look for the other info here

Hi I'm new.

A new interesting link about the connection between MPB and HSV-1 virus:

http://www.freepatentsonline.com/y2008/0160509.html

Kratos wrote:Hi I'm new.

A new interesting link about the connection between MPB and HSV-1 virus:

http://www.freepatentsonline.com/y2008/0160509.html

That's quite interesting...

Welcome to the forum Kratos.

HSV 1 and hair loss is more of a casual link IMO. Think of the HSV's as a toxin as that's essentially what they are. HSV 1 said to cause lymph and skin issues... but again, a toxin based on my research.

FWIW, here is a good quote regarding DKK-1.

Interestingly,
DKK1, the target gene of this GO term, has been shown
to be up-regulated in acute C. pneumoniae infection in a study
parallel to ours [20].

http://www.journals.uchicago.edu/doi/pdf/10.1086/524142

Mycoplasma commonly carries along chlamydia pneuomonia (not an STD) as well as HSV-3.

Interestingly, keeping glutathione levels high is a way to keep mycoplasma's life cycle in check.

hope this helps