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The Case For Starch
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The Case For Starch
Did a Starchy Diet Fuel Gene Copying in Early Humans?
http://www.scitizen.com/evolution/did-a-starchy-diet-fuel-gene-copying-in-early-humans-_a-27-1263.html
Did a Starchy Diet Fuel Gene Copying in Early Humans?
Biologists usually think of gene mutations as the raw material for evolution. But a wide-ranging analysis of a correlation between genes and diet across many different cultures has unveiled a second starting point for natural selection: extra, unmutated copies of an existing gene. A particular set of gene copies helped early humans thrive on starchy foods that other primates ignored, possibly explaining the energy source for the growing brains of our ancestors.
The findings, published in Nature Genetics in October 2007, examine the gene for salivary amylase, an enzyme in saliva that digests starch. Plants use starch – long chains of sugar molecules – to protect their fuel stores, often stockpiling the sugar chains underground in tubers. A research team led by anthropologist Nathaniel Dominy suspected that humans, avid eaters of domesticated tubers such as carrots and potatoes, evolved a more effective salivary amylase enzyme than other primates, which eat mostly low-starch fruits. But instead of a better enzyme, the team found humans have more copies – Xeroxes, essentially – of the salivary amylase gene.
To figure out what the extra gene copies were doing, Dominy’s team compared dietary data, saliva samples, and DNA from chimpanzees and people. Initial tests showed American college students had anywhere from 2 to 15 copies of the salivary amylase gene, and that students with more gene copies had more of the amylase enzyme in their saliva. The team then looked to other populations for a link between gene copies and diet.
They studied seven populations with low-starch or high-starch diets. Groups with low-starch diets – an unusual pattern for most modern humans – were two African hunter-gatherer tribes and a tribe of African pastoralists, all with meat-heavy diets, as well as fish-eating Yakut people of the Asian Arctic. The high-starch groups were Japanese people and European-Americans, eaters of starchy rice and bread, and an African tribe that eats starchy plant parts such as wild yams. The researchers counted copies of the salivary amylase gene in the subjects’ DNA.
The results showed that chimpanzees, which subsist mostly on fruit, have only 2 copies of the gene and low enzyme levels. In contrast, most humans have several additional gene copies. If a population eats more starch, its members have more copies of the gene, on average. For instance, individuals with at least 6 gene copies were more than twice as common in starch-eating groups compared to groups with low-starch diets.
This strong link between gene copy number and diet is noteworthy for two reasons. First, it shows a new route for evolution: Instead of waiting for a beneficial mutation to pop up, evolution can favor duplicating existing genes with useful functions. Extra gene copies can ramp up the gene’s function in the body.
Second, the study could explain how humans grew such big brains. Brain tissue is the body’s biggest gas guzzler. Becoming the brainiest primate, as our ancestors did, required a reliable supply of sugar. Some scientists have doubted whether meat alone could have fueled brain growth, since early humans probably ate meat sporadically. With efficient methods for digesting starchy plant parts hidden underground, pre-humans tapped an unused energy source with an abundant supply.
Not only were the new foods readily available, they had the advantage of being less fibrous than fruits. Reducing dietary fiber seems backwards now. For modern humans, it’s a struggle to eat roughage and “stay regular.” But our ancestors had the opposite problem: they ate so much indigestible plant matter that their bodies had to spend vast amounts of energy just grinding away at their food. The switch to starchy foods saved calories, let early humans grow shorter guts, and left more sugar to feed their brains.
Digesting more starch obviously was a good thing, but why did humans end up grinding starch in their mouths? The blood vessels in our cheeks can absorb a bit of sugar, but most nutrients cross to the bloodstream at the small intestine. Dominy’s team thinks the mouth became a more important place to pick up nutrients when food became scarce. By breaking down starch there, humans could eat marginal foods. Stringy plants like sugar cane became accessible foods because humans could extract nutrients by sucking on the plants without swallowing, and plants containing mild toxins were edible if humans could get calories out of them quickly, before the toxins caused a gut-emptying bout of diarrhea.
Starch is everywhere today, from Pop-Tarts to French fries. But in the Congo, tribes of African pygmies still dig up some of the original starchy tubers that apparently fed human evolution – wild yams as small as your thumb or nearly as big as a VW Beetle.
http://en.wikipedia.org/wiki/Amylase#Human_evolution
Human evolution
Carbohydrates are an energy rich food source. Amylase is thought to have played a key role in human evolution in allowing humans an alternative to fruit and protein. A duplication of the pancreatic amylase gene developed independently in humans and rodents, further suggesting its importance. The salivary amylase levels found in the human lineage are six to eight times higher in humans than in chimpanzees, which are mostly fruit eaters and ingest little starch relative to humans.[13]
http://www.scitizen.com/evolution/did-a-starchy-diet-fuel-gene-copying-in-early-humans-_a-27-1263.html
Did a Starchy Diet Fuel Gene Copying in Early Humans?
Biologists usually think of gene mutations as the raw material for evolution. But a wide-ranging analysis of a correlation between genes and diet across many different cultures has unveiled a second starting point for natural selection: extra, unmutated copies of an existing gene. A particular set of gene copies helped early humans thrive on starchy foods that other primates ignored, possibly explaining the energy source for the growing brains of our ancestors.
The findings, published in Nature Genetics in October 2007, examine the gene for salivary amylase, an enzyme in saliva that digests starch. Plants use starch – long chains of sugar molecules – to protect their fuel stores, often stockpiling the sugar chains underground in tubers. A research team led by anthropologist Nathaniel Dominy suspected that humans, avid eaters of domesticated tubers such as carrots and potatoes, evolved a more effective salivary amylase enzyme than other primates, which eat mostly low-starch fruits. But instead of a better enzyme, the team found humans have more copies – Xeroxes, essentially – of the salivary amylase gene.
To figure out what the extra gene copies were doing, Dominy’s team compared dietary data, saliva samples, and DNA from chimpanzees and people. Initial tests showed American college students had anywhere from 2 to 15 copies of the salivary amylase gene, and that students with more gene copies had more of the amylase enzyme in their saliva. The team then looked to other populations for a link between gene copies and diet.
They studied seven populations with low-starch or high-starch diets. Groups with low-starch diets – an unusual pattern for most modern humans – were two African hunter-gatherer tribes and a tribe of African pastoralists, all with meat-heavy diets, as well as fish-eating Yakut people of the Asian Arctic. The high-starch groups were Japanese people and European-Americans, eaters of starchy rice and bread, and an African tribe that eats starchy plant parts such as wild yams. The researchers counted copies of the salivary amylase gene in the subjects’ DNA.
The results showed that chimpanzees, which subsist mostly on fruit, have only 2 copies of the gene and low enzyme levels. In contrast, most humans have several additional gene copies. If a population eats more starch, its members have more copies of the gene, on average. For instance, individuals with at least 6 gene copies were more than twice as common in starch-eating groups compared to groups with low-starch diets.
This strong link between gene copy number and diet is noteworthy for two reasons. First, it shows a new route for evolution: Instead of waiting for a beneficial mutation to pop up, evolution can favor duplicating existing genes with useful functions. Extra gene copies can ramp up the gene’s function in the body.
Second, the study could explain how humans grew such big brains. Brain tissue is the body’s biggest gas guzzler. Becoming the brainiest primate, as our ancestors did, required a reliable supply of sugar. Some scientists have doubted whether meat alone could have fueled brain growth, since early humans probably ate meat sporadically. With efficient methods for digesting starchy plant parts hidden underground, pre-humans tapped an unused energy source with an abundant supply.
Not only were the new foods readily available, they had the advantage of being less fibrous than fruits. Reducing dietary fiber seems backwards now. For modern humans, it’s a struggle to eat roughage and “stay regular.” But our ancestors had the opposite problem: they ate so much indigestible plant matter that their bodies had to spend vast amounts of energy just grinding away at their food. The switch to starchy foods saved calories, let early humans grow shorter guts, and left more sugar to feed their brains.
Digesting more starch obviously was a good thing, but why did humans end up grinding starch in their mouths? The blood vessels in our cheeks can absorb a bit of sugar, but most nutrients cross to the bloodstream at the small intestine. Dominy’s team thinks the mouth became a more important place to pick up nutrients when food became scarce. By breaking down starch there, humans could eat marginal foods. Stringy plants like sugar cane became accessible foods because humans could extract nutrients by sucking on the plants without swallowing, and plants containing mild toxins were edible if humans could get calories out of them quickly, before the toxins caused a gut-emptying bout of diarrhea.
Starch is everywhere today, from Pop-Tarts to French fries. But in the Congo, tribes of African pygmies still dig up some of the original starchy tubers that apparently fed human evolution – wild yams as small as your thumb or nearly as big as a VW Beetle.
http://en.wikipedia.org/wiki/Amylase#Human_evolution
Human evolution
Carbohydrates are an energy rich food source. Amylase is thought to have played a key role in human evolution in allowing humans an alternative to fruit and protein. A duplication of the pancreatic amylase gene developed independently in humans and rodents, further suggesting its importance. The salivary amylase levels found in the human lineage are six to eight times higher in humans than in chimpanzees, which are mostly fruit eaters and ingest little starch relative to humans.[13]
zanza- Posts : 138
Join date : 2010-06-18
Re: The Case For Starch
Thats nice, but excessive starch will make you fat. One of the bigger healthscams was and still is(?) doctors telling people to stay clear of fat but make sure to eat plenty of bread, spaghetti, baked poatatoes and so forth everyday. The result is total obesity epidemic in the society and growing numbers of sick people going bankrupt for healthcare and making doctors very rich and important at the same time.
Amaranthaceae- Posts : 1368
Join date : 2008-07-15
Location : Copenhagen
Re: The Case For Starch
The dentist I went back in the 90s told me the fact that some people have greater salivary amylase enzyme in their mouths than others. This was the reason why people who produce less of this enzyme in their salivary glands and who ate a lot of starchy carbs like the pasta and breads were prone to tooth decay. The study makes it appear that that their are many people with greater enzyme output, but my dentist was of the opinion that this was not common. But then his job is to see bad teeth all day long, so I don't know what is true.
tonyj- Posts : 390
Join date : 2009-10-03
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