CS- RU58841

What is your opinion about the RU58841, it may be safer than drugs like Propecia ?

Steven_Tyler - Possibly, however I would imagine by now that the drug-based hair loss forums would have given this a fair assessment by this time. It's been a few years since the last study on it.

Pharmazie. 2005 Jan;60(1):8-12.
RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia.
Münster U, Nakamura C, Haberland A, Jores K, Mehnert W, Rummel S, Schaller M, Korting HC, Zouboulis ChC, Blume-Peytavi U, Schäfer-Korting M.

Pharmakologie und Toxikologie, Institut für Pharmazie, Freie Universität Berlin, Germany.

Acne and androgenetic alopecia are linked to androgen effects and therefore should improve following topical application of antiandrogens. We present a new antiandrogen prodrug, RU 58841-myristate (RUM) for topical therapy. Almost devoid of affinity to the androgen receptor, as derived from investigations in the mouse fibroblast cell line 29 +/GR +, RUM is rapidly metabolised to the potent antiandrogen RU 58841 by cultured human foreskin fibroblasts and keratinocytes, male occipital scalp skin dermal papilla cells, and by cells of the sebaceous gland cell line SZ95. In order to improve a specific targeting of the hair follicle, RUM was loaded on solid lipid nanoparticles (SLN), which are already known to support dermal targeting effects. Physically stable RUM loaded SLN were produced by hot homogenization. Penetration/permeation studies carried out using the Franz diffusion cell proved only negligible permeation of reconstructed epidermis and excised porcine skin within 6 h, implying a more topical action of the drug. Targeting to the hair follicle using SLN was visualised by fluorescence microscopy, following the application of Nile Red labelled SLN to human scalp skin. Transmission electron microscopy (TEM) allowed to detect intact silver labelled SLN in porcine hair follicles of preparations applied to the skin for 24 h. RUM loaded SLN should be considered for topical antiandrogen therapy of acne and androgenetic alopecia.

StevenTyler-

I tried this about a year or so ago. It made me feel pretty run-down. On the surface, it's a brilliant concept. However, I have no doubt from my own experiences and others that it's systemic effects via the Nilutamide can be quite unsettling for those who suffer sides. Then again, there a are a number of people who use it on HLH and don't complain about any side effects and seem to just get the benefits.

The other thing that is not too fun is you have to apply this to your head in a base of 99% ethanol for an even distribution and penetration of the scalp. Over on HLH they talk about this alot. It made me feel pretty tired and weak, not too mention set me back $250. I still have about 3.5-4 grams in the freezer waiting, but I have given up.

RUM or RU 58841-myristate is currently being made for those with sides on standard RU. PM me for info

Not sure if these help anyone. Some old videos I made. Some people may be interested in RU and RUM. I think videos are the best way to learn.

Normal RU58841


Here is some info on RUM


This one was a little more targeted for a different audience but it shows some of the biochem