An unbelievable wrinkle remover but could it be dangerous?

Geranylgeranylacetone is a very potent chemical that induces naturally made molecules inside cells (from bacteria to human) called heat shock proteins (HSP’s). It effects several classes of these, including HSP 70 and 90 families. The stress-inducible chaperone heat shock protein (HSP) 70 is considered a danger signal if released into the extracellular environment. It has been proposed to play a role in the pathogenesis of skin diseases such as psoriasis and lupus erythematosus (Exp Dermatol. 2011 Aug;20(:637-41). Hsp70 has been found to act as a recognition structure for natural killer (NK) cells in the body. (Int J Hyperthermia. 2009 May;25(3):169-75.). Cells transformed by Hsp70 are tagged as senescent and targeted for destruction by our indwelling immune system assassins, killer T cells.

Geranylgeranylacetone induces apoptosis (programmed cell death) and cell cycle arrest as well as cell growth inhibition (Oncogene. 2001 May 24;20(23):2927-36). This is quite likely why it slows down fibroblasts in culture (prolonging their life, by making them a lot less active). This drug may have anti-cancer effects for these very reasons. But as an anti-aging strategy, it lacks logic. Even if it does make fibroblasts in the skin live longer, it slows down the production of matrix proteins (like collagen) which would accelerate the signs of aging.