23 And Me DNA Results

Here are my DNA results through 23andme.com. If anyone has any insights as to health implications or hair loss I would love to hear your thoughts.

Thanks friends!

INHERITED CONDITIONS

Hemochromatosis (HFE-related) = variant present.

Iron, an essential mineral, is absorbed via the intestines from food and is important for many bodily functions including red blood cell formation and proper brain function. The iron absorption process must be tightly regulated or else iron can accumulate in the body, possibly causing organ damage. Inherited forms of iron overload, known as hereditary hemochromatosis (HH), are caused by mutations in genes that normally play important roles in regulating iron levels. This report includes three mutations in the HFE gene that are typically found in people with European ancestry and are responsible for most cases of HH. HFE-related HH is inherited in a recessive manner, meaning that a person must receive a mutated copy of the HFE gene from each parent to have the condition. In Europeans, roughly one in 300 individuals has HFE-related HH and at least one in 10 carries a mutation for the condition. Rates are even higher in certain European populations including Irish, Norwegian and Australian. HFE-related HH is much rarer in Asian and African populations.

Me: Has one mutation in the HFE gene linked to hemochromatosis. A person with one of these mutations is not typically prone to higher levels of iron in the body, but can pass the mutation to offspring. May have other mutations in the HFE gene (not reported here).

DRUG RESPONSE

Proton Pump Inhibitor (PPI) Metabolism

Proton pump inhibitors (PPIs) are drugs that limit the production of stomach acid. They are used to treat gastrointestinal conditions like ulcers, acid reflux disease, and infection by common stomach bacteria called H. pylori. The ability of PPIs to reduce stomach acid production depends not only on factors like age, size, diet, kidney and liver function and other medications, but also on genetics. Depending on their genetics, some people may need different doses of PPIs to effectively reduce stomach acid production and help heal acid damage. PPIs are sold under many names, including omeprazole (Prilosec®), lansoprazole (Prevacid®), rabeprazole (AcipHex®) and esomeprazole (Nexium®).

Me: Intermediate metabolizer. Someone with this genotype typically metabolizes PPIs at a moderate rate. Standard doses are usually effective for people with this genotype.

HEALTH RISKS

Elevated Risks     Your Risk     Average Risk
Prostate Cancer         30.5% 17.8%
Chronic Kidney Disease 4.2%   3.4%
Rheumatoid Arthritis 3.5%   2.4%
Restless Legs Syndrome 2.5% 2.0%
Ulcerative Colitis   1.3%   0.8%

ANCESTRY COMPOSITION
Ancestry Composition tells you what percent of your DNA comes from each of 31 populations worldwide. The analysis includes DNA you received from all of your ancestors, on both sides of your family. The results reflect where your ancestors lived 500 years ago, before ocean-crossing ships and airplanes came on the scene.

Me: 99.9% European



(Northern European)
British and Irish 51.2%
Finish <0.1%
French and German <0.1%

Non specific Northern European 44.4%
Nonspecific European 4.3%
Unassigned 0.1%

Neanderthal ancestry
Me: An estimated 2.9% of your DNA is from Neanderthals. (83rd percentile among Europeans on 23andme database)

When did you get this done? I thought the FDA shut down the interpretation of these results (cancer risk) by 23andme.

I just got in before the cut off! Your right they do not interpret health results anymore.

I'm trying to interpret the info in terms of what my ancestors ate, genetic expression and DNA traits. Not sure how to go about it.

Going by Dr Weston Price's work (Nutrition and Physical Degeneration) Northern European cultures did not consume rice, beans, and corn for instance. These cultures also ate little if any fruit or raw vegetables. They did eat a high animal protein diet with plenty of quality fats, sourdough breads, vegetables were usually fermented or cooked in stews and organ meats.

Perhaps focusing our staple whole foods on the cultures from which we obtained our genome is a good direction for choosing ones individual diet.

Have you tried putting your raw data through something like geneticgenie.org? That's what most people seem to use these results for elsewhere.

Grub wrote:Going by Dr Weston Price's work (Nutrition and Physical Degeneration) Northern European cultures did not consume rice, beans, and corn for instance. These cultures also ate little if any fruit or raw vegetables. They did eat a high animal protein diet with plenty of quality fats, sourdough breads, vegetables were usually fermented or cooked in stews and organ meats.

Perhaps focusing our staple whole foods on the cultures from which we obtained our genome is a good direction for choosing ones individual diet.

Lol @ Weston Price...

All of the above is mucus forming .

Unim wrote:Have you tried putting your raw data through something like geneticgenie.org? That's what most people seem to use these results for elsewhere.

Ill check it out. Thanks man.

Have a read of this yup:

http://journeytoforever.org/farm_library/price/pricetoc.html

What is your mthfr status?

They do not list mthfr status?

Grub wrote:Here are my DNA results through 23andme.com. If anyone has any insights as to health implications or hair loss I would love to hear your thoughts.

Thanks friends!

INHERITED CONDITIONS

Hemochromatosis (HFE-related) = variant present.

Iron, an essential mineral, is absorbed via the intestines from food and is important for many bodily functions including red blood cell formation and proper brain function. The iron absorption process must be tightly regulated or else iron can accumulate in the body, possibly causing organ damage. Inherited forms of iron overload, known as hereditary hemochromatosis (HH), are caused by mutations in genes that normally play important roles in regulating iron levels. This report includes three mutations in the HFE gene that are typically found in people with European ancestry and are responsible for most cases of HH. HFE-related HH is inherited in a recessive manner, meaning that a person must receive a mutated copy of the HFE gene from each parent to have the condition. In Europeans, roughly one in 300 individuals has HFE-related HH and at least one in 10 carries a mutation for the condition. Rates are even higher in certain European populations including Irish, Norwegian and Australian. HFE-related HH is much rarer in Asian and African populations.

Me: Has one mutation in the HFE gene linked to hemochromatosis. A person with one of these mutations is not typically prone to higher levels of iron in the body, but can pass the mutation to offspring. May have other mutations in the HFE gene (not reported here).

DRUG RESPONSE

Proton Pump Inhibitor (PPI) Metabolism

Proton pump inhibitors (PPIs) are drugs that limit the production of stomach acid. They are used to treat gastrointestinal conditions like ulcers, acid reflux disease, and infection by common stomach bacteria called H. pylori. The ability of PPIs to reduce stomach acid production depends not only on factors like age, size, diet, kidney and liver function and other medications, but also on genetics. Depending on their genetics, some people may need different doses of PPIs to effectively reduce stomach acid production and help heal acid damage. PPIs are sold under many names, including omeprazole (Prilosec®), lansoprazole (Prevacid®), rabeprazole (AcipHex®) and esomeprazole (Nexium®).

Me: Intermediate metabolizer. Someone with this genotype typically metabolizes PPIs at a moderate rate. Standard doses are usually effective for people with this genotype.

HEALTH RISKS

Elevated Risks          Your Risk      Average Risk
Prostate Cancer             30.5%    17.8%
Chronic Kidney Disease    4.2%      3.4%
Rheumatoid Arthritis       3.5%      2.4%
Restless Legs Syndrome 2.5%       2.0%
Ulcerative Colitis            1.3%      0.8%

ANCESTRY COMPOSITION
Ancestry Composition tells you what percent of your DNA comes from each of 31 populations worldwide. The analysis includes DNA you received from all of your ancestors, on both sides of your family. The results reflect where your ancestors lived 500 years ago, before ocean-crossing ships and airplanes came on the scene.

Me: 99.9% European



(Northern European)
British and Irish 51.2%
Finish <0.1%
French and German <0.1%

Non specific Northern European 44.4%
Nonspecific European 4.3%
Unassigned 0.1%

Neanderthal ancestry
Me: An estimated 2.9% of your DNA is from Neanderthals. (83rd percentile among Europeans on 23andme database)

Where did you find the inherited conditions and health risks info?

They have stopped interpreting health results now due to fda regulations