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Substitutes for minoxidil
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Joey
need45
orwell
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Nocturnalhorse
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CausticSymmetry
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20 posters
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Re: Substitutes for minoxidil
Used generic Minox for about 2 weeks a few years back and it caused havoc with my scalp in terms of itch so had to drop it. Recently been thinking about giving minox another go but maybe using another formula such as lipogaine. My crown has steadily got worse over the last couple of years and unfortunately my own belief is there isn't much out there at the moment in terms of a natural topical that will result in any noticeable regrowth
Joey- Posts : 76
Join date : 2009-11-07
Re: Substitutes for minoxidil
So, CS, if I understand you correctly, If I were to make a topical of cayenne and epsom salts (which, in my understanding is magnesium sulphate), it would be a kind of minoxidil-a-like?CausticSymmetry wrote:tao81 - Given this latest study, I have two different proposals on an alternative to minoxidil that does not involve antioxidants.
Curr Med Chem. 2008;15(29):3095-112.
Promotion of Insulin-Like Growth Factor-I Production by Sensory Neuron Stimulation; Molecular Mechanism(s) and Therapeutic Implications.
Okajima K, Harada N.
Department of Translational Medical Science Research, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. whynot@med.nagoya-cu.ac.jp.
Insulin-like growth factor-I (IGF-I) plays various important roles in cellular proliferation, differentiation, survival and functions of the cell, thereby contributing to the maintenance of tissue integrity. Although it is well known that growth hormone (GH) increases serum IGF-I levels by stimulating the hepatic production, little is known about the mechanism by which local production of IGF-I in individual tissues is regulated. Stimulation of sensory neurons by capsaicin increases tissue levels of IGF-I and IGF-I mRNA in various organs via increased calcitonin gene-related peptide (CGRP) release in mice. This sensory neuron-mediated IGF-I production contributes to reducing reperfusion-induced liver injury through prevention of apoptosis in mice. Isoflavone, a phytoestrogen, increases CGRP production by increasing its transcription in sensory neurons. Administration of capsaicin and isoflavone increases IGF-I production in hair follicles, thereby promoting hair growth in mice and in volunteers with alopecia. Topical application of capsaicin increases dermal levels of IGF-I by stimulating sensory neurons in mice and increases facial skin elasticity in humans. Plasma and tissue levels of CGRP and IGF-I in spontaneously hypertensive rats (SHR) are lower than those in normotensive Wistar Kyoto rats (WKY), contributing to the development of hypertension, heart failure and insulin resistance in SHR. Administration of capsaicin increases CGRP and IGF-I levels in plasma, kidneys and the heart in SHR to WKY levels, and normalizes mean arterial blood pressure in SHR. Since administration of GH or IGF-I has some deleterious effects, pharmacological stimulation of sensory neurons leading to increased tissue IGF-I levels might be a novel therapeutic strategy for various pathologic conditions.
Considering that minoxidil was originally used to treat high blood pressure (hypertension) and that hypertensive rats have lower levels of IGF-1 & calcitonin gene-related peptide (CGRP), the use of Cayenne topically would increase both.
Of course minoxidil works by opening of the ATP sensitive potassium channels. But what else does this? Magnesium.
Consider that Magnesium is practically void in today's foods--foods that are suppose to be loaded with it. Commercial farming is the reason.
Topical and internal Magnesium is a way to increase ATP via potassium channels. Magnesium oil or gel for topical use and Magnesium in primarily in non-oxide form for internal use.
Hairy Potter- Posts : 379
Join date : 2013-06-21
Re: Substitutes for minoxidil
I would not propose that idea. My experiences with cayenne over 20 years have not been good.
This includes topically and internally. Yes, I am aware that a very small amount can help internally. Anything more than that can produce a shed.
In recent thread I proposed how to produce similar effects to minoxidil without the sides.
It's within the last 10 posts (I do not recall which thread it was at the moment).
This includes topically and internally. Yes, I am aware that a very small amount can help internally. Anything more than that can produce a shed.
In recent thread I proposed how to produce similar effects to minoxidil without the sides.
It's within the last 10 posts (I do not recall which thread it was at the moment).
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Re: Substitutes for minoxidil
Hi CS, OK great, thanks for that and very good to know - the post you mention above is this one, in case anyone else is interested: https://immortalhair.forumotion.com/t9660-a-randomized-evaluator-blinded-study-of-effect-of-microneedling-in-androgenetic-alopecia-a-pilot-study#98901.CausticSymmetry wrote:I would not propose that idea. My experiences with cayenne over 20 years have not been good.
This includes topically and internally. Yes, I am aware that a very small amount can help internally. Anything more than that can produce a shed.
In recent thread I proposed how to produce similar effects to minoxidil without the sides.
It's within the last 10 posts (I do not recall which thread it was at the moment).
In your first link it appears that you are talking about 40,000 volts?
Hairy Potter- Posts : 379
Join date : 2013-06-21
Re: Substitutes for minoxidil
Hi CSCausticSymmetry wrote:I would not propose that idea. My experiences with cayenne over 20 years have not been good.
This includes topically and internally. Yes, I am aware that a very small amount can help internally. Anything more than that can produce a shed.
In recent thread I proposed how to produce similar effects to minoxidil without the sides.
It's within the last 10 posts (I do not recall which thread it was at the moment).
Great info! One thing though- When you say cayenne can cause a "shed" what kind of shed do you mean exactly? Please elaborate. Thanks!
Complexx- Posts : 885
Join date : 2013-07-07
Re: Substitutes for minoxidil
PS: Can you share your bad experiences that you've had with capsaicin/cayenne CS? I'd really appreciate it.
Complexx- Posts : 885
Join date : 2013-07-07
Re: Substitutes for minoxidil
Misirlou wrote:Reversing hair loss or just halting it requires a great deal of patience...5 weeks is not enough
Hi, have you managed to halt hair loss?
Thanks
ElmoSuper8- Posts : 362
Join date : 2013-08-14
Re: Substitutes for minoxidil
I'm currently using thermal scalp along with other topicals
http://www.iherb.com/product-reviews/Greensations-ThermaScalp-Natural-Scalp-Repair-4-fl-oz-120-ml/25808/?p=1
Don't know if it's working yet, plus I'm taking supps and doing brushing + detu so it's hard to tell what does what...
http://www.iherb.com/product-reviews/Greensations-ThermaScalp-Natural-Scalp-Repair-4-fl-oz-120-ml/25808/?p=1
Don't know if it's working yet, plus I'm taking supps and doing brushing + detu so it's hard to tell what does what...
radiance- Posts : 99
Join date : 2013-12-20
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