Premature graying as a consequence of compromised antioxidant activity in hair bulb melanocytes and their precursors.

PLoS One. 2014 Apr 2;9(4):e93589. doi: 10.1371/journal.pone.0093589. eCollection 2014.
Premature graying as a consequence of compromised antioxidant activity in hair bulb melanocytes and their precursors.
Shi Y, Luo LF, Liu XM, Zhou Q, Xu SZ, Lei TC.

Intricate coordinated mechanisms that govern the synchrony of hair growth and melanin synthesis remain largely unclear. These two events can be uncoupled in prematurely gray hair, probably due to oxidative insults that lead to the death of oxidative stress-sensitive melanocytes. In this study, we examined the gene expression profiles of middle (bulge) and lower (hair bulb) segments that had been micro-dissected from unpigmented and from normally pigmented hair follicles from the same donors using quantitative real-time RT-PCR (qPCR) arrays. We found a significant down-regulation of melanogenesis-related genes (TYR, TYRP1, MITF, PAX3, POMC) in unpigmented hair bulbs and of marker genes typical for melanocyte precursor cells (PAX3, SOX10, DCT) in unpigmented mid-segments compared with their pigmented analogues. qPCR, western blotting and spin trapping assays revealed that catalase protein expression and hydroxyl radical scavenging activities are strongly repressed in unpigmented hair follicles. These data provide the first clear evidence that compromised antioxidant activity in gray hair follicles simultaneously affects mature hair bulb melanocytes and their immature precursor cells in the bulge region.

Full study:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973559/

Nice. Thanks IH.