Zinc inhibits DHT upto 90% when combinedwith B6,Azelaic acid

Hi all
Just crusin the internet and came acros this article, if has this been discussed before I am sorry to double up .http://www.follicle.com/section2/2.html

Zinc
Some vitamins have been shown to inhibit the activity of 5-alpha reductase and the subsequent production of (DHT) dihydrotestosterone. These vitamins therefore may be of great benefit in the treatment of Androgenetic Alopecia or pattern baldness. There have been studies in which Zinc is shown to inhibit 5 alpha reductase activity and it has therefore been concluded than Zinc is beneficial in disease and disorders related t an excess in dihydrotestosterone (DHT). There have also been studies which have shown that vitamin B6, Zinc and Azelaic Acid combined together even at very low concentrations reduced a 90% inhibition of 5 alpha reductase activity.

In humans or in mice?

To be pragmatic about it, whatever test subjects were originally used, the fact is that Zix (small concentrations of zinc sulfate, and vitamin b-6 (in pyridoxal-5-phosphate form), dissolved in distilled water), re-grows hair, terminal hair, and cosmetically quite viable, in humans, and on the frontal hairline, not just the crown/baldspot area. And there have been many many solid anecdotal reports of this over the years, and I can vouch for it myself from my own personal experience. You just have to do it right, be committed, and stick with it. This stuff is far, far more powerful than rogaine and propecia, even combined, could ever be. AND with zero side effects.

[quote="LawOfThelema"]In humans or in mice?[/quot
Hi law

In humans
Here is the full article


Androgenetic Alopecia
Male Pattern Baldness / Female Pattern Baldness

Androgenetic Alopecia accounts for 95% of all hair loss. It can affect both men and women although men experience a much greater degree of loss. In women Androgenetic Alopecia appears as diffuse hair loss occurring over most of the scalp. In men however the pattern of loss usually starts with a receding hairline which then advances to thin the top of the head.

Causes of Androgenetic Alopecia

In 400 BC Hippocrates observed that eunuchs did not become bald. Later Aristotle noticed this also. In the 1940s Dr James Hamilton concluded that genetic predisposition in the present of the male hormone androgen where the factors that caused the development of Androgenetic Alopecia.

However it is now known that it is more specifically the male hormone dihydrotestosterone (DHT) which is converted from the enzyme testosterone by the enzymes 5 alpha reductase which contributes to Androgenetic Alopecia in those who are genetically predisposed. It is interesting to note that individuals with a deficiency in 5 alpha reductase do not develop Androgenetic Alopecia. This is because the body is unable to convert testosterone into dihydrotestosterone.

When Androgenetic Alopecia occurs large active hair follicles in specific areas begin to change to smaller less active ones that shrink slightly with each new growth cycle. The enzyme 5 alpha reductase is thought to be the major cause of this. Under the action of the enzyme the male hormone testosterone become dihydrotestosterone. This causes the hair shafts to narrow producing progressively finer hairs with each new growth cycle until eventually the hairs become transparent and stop emerging. If an individual has androgenetic alopecia the overall levels of testosterone may be normal however the activity of 5 alpha reductase is greater than normal which results in increased amounts of dihydrotestosterone in the hair follicle.

Treatments for Androgenetic Alopecia

Minoxidil
Minoxidil is the most widely recommended treatment for Androgenetic Alopecia. In the United States topical Minoxidil is marketed under the brand name Rogaine in New Zealand it is marketed as Regaine and recently a generic version of topical Minoxidil has become available under the brand name Headway. Minoxidil appears to work by gradually enlarging and lengthening hair follicles which have been gradually shrinking due to Androgenetic Alopecia. The growth phase may also be extended giving the hairs an opportunity to reach a longer length before they fall out.

It is necessary to use Minoxidil for about 3-4 months to see evidence of regrowth and up to 6 months to get a proper estimate of whether Minoxidil will be helpful in a particular case. Minoxidil also requires continual use in order to be effective. Once application of Minoxidil is ceased the hair will return to the original state in about 3 months.

The two main disadvantages of using Minoxidil is that first of all its use must be continued in order to maintain the results achieved and the second disadvantage is the expense. Minoxidil is however becoming more affordable and the generic version Headway which is cheaper makes Minoxidil more affordable.

Propecia (finasteride)
Propecia is a relatively new drug produce by Merck. It is a tablet which is taken once a day and at this present time it is only approved for use in men. Propecia is not to be used by woman and children. Propecia is a 4 aza steroid compound that is a specific inhibitor of type 2 5 alpha reductase which is the enzyme that metabolises the androgen testosterone into dihydrotestosterone (DHT). In this way Propecia helps to prevent the continued miniaturisation of existing hair follicles and also assist in the recruitment of miniaturised hair follicles to become terminal hairs. Like Minoxidil, Propecia must be taken for a period of 3 months or more before any benefit is seen and it must be continued in order to maintain any benefits gained. Propecia is also expensive to maintain.

Retin-A / Tretinoin
Retin was originally used in the treatment of acne and other skin disorders. However studies have shown that Retin-A alone or in combination with Minoxidil can result in moderate to good hair growth in individuals with Androgenetic Alopecia and Alopecia Areata. Many dermatologist recommend using Tretinoin in combination with Minoxidil to increase the effects of both these products. Side effects of Retin-A include blistering, altered pigmentation and increased sensitivity to light. If a gel is used it is suggested that Minoxidil be applied in the morning a Retin-A gel in the evening to reduce the problems caused by sunlight.

Zinc
Some vitamins have been shown to inhibit the activity of 5-alpha reductase and the subsequent production of (DHT) dihydrotestosterone. These vitamins therefore may be of great benefit in the treatment of Androgenetic Alopecia or pattern baldness. There have been studies in which Zinc is shown to inhibit 5 alpha reductase activity and it has therefore been concluded than Zinc is beneficial in disease and disorders related t an excess in dihydrotestosterone (DHT). There have also been studies which have shown that vitamin B6, Zinc and Azelaic Acid combined together even at very low concentrations reduced a 90% inhibition of 5 alpha reductase activity.

Skinoren / Azelaic Acid
Azelaic Acid like Retin-A is more commonly used in the treatment of acne and other skin conditions. Recently the potential effect of using Azelaic Acid in the treatment of Androgenetic Alopecia has been looked at and discussed.

Studies carried out in France in the late 80’s where to assess the effects of Zinc Sulphate, a Azelaic Acid on the human skin. The result of these studies demonstrated that at high concentrations Zinc could completely inhibit the activity of 5 alpha reductase. Azelaic Acid was also shown to be a potent inhibitor of 5 alpha reductase. Inhibition was detectable at concentrations as low as 0.2mmol/l and was complete at 3mmol/l. When Zinc, Vitamin B6 and Azelaic Acid where added together at very low concentrations which had been ineffective alone, 90% inhibition of 5 alpha reductase was achieved.

Saw Palmetto extract
Studies have shown that Saw Palmetto is an effective anti-androgen. It acts in a similar way that Propecia does. Firstly it lowers levels of DHT in the body by blocking 5 alpha-reductase. Secondly Saw Palmetto block receptor sites on cell membranes required for cells to absorb DHT. Although no studies have been carried out on Saw Palmetto and its relation to hair growth. Studies have been performed on the use of Saw palmetto in the treatment of benign prostatic disease which similar to Androgenetic Alopecia also depends on the production of dihydrotestosterone. All of the studies that have been performed to date show that Saw Palmetto is an effective antiandrogen and has shown conclusively to be effective in the treatment of benign prostratic disease.

One may assume from this that since Saw Palmetto is an effective antiandrogen and is used in the treatment of prostatic disease then it may also be effective in the treatment of Androgenetic Alopecia.


Cheers
Mikeyc.

this is pretty much what revivogen contains and its results aren't that spectacular so I don't know what to think

moby wrote:this is pretty much what revivogen contains and its results aren't that spectacular so I don't know what to think

Wow negativity to the max there "Moby" you say that results arn't that spectacular BUT there are results, it may be better for some more than others, SPECTACULAR RESULTS do not come from anything at the moment in this era of hair loss, if there was WE WOULD ALL BE DOING IT AND THESE FORUMS WOULDN'T EXSIST !!! but all these things can possibly help, take it as more helpful info in the fight against DHT.

Cheers
Mikeyc.

mikeyc wrote:
Wow negativity to the max there "Moby" you say that results arn't that spectacular BUT there are results, it may be better for some more than others, SPECTACULAR RESULTS do not come from anything at the moment in this era of hair loss, if there was WE WOULD ALL BE DOING IT AND THESE FORUMS WOULDN'T EXSIST !!! but all these things can possibly help, take it as more helpful info in the fight against DHT.

I meant it in a sarcastic way wow this forum is so harsh for newbies I've been using revivogen myself and it may have reduced my shedding and perhaps slowed down hair loss a little but that's it. Pretty sure actual 90% DHT reduction would have done much much better

Hi Moby

I am a newbie also in this forum sorry if it came across harsh but sarcasm dosn't translate well in written form how long have you been using revivogen for ?

Cheers
Mikeyc.

[quote="moby"]this is pretty much what revivogen contains and its results aren't that spectacular so I don't know what to think [/quo

I've kept track of a lot of these testimonials on various discussion boards for years, and I hardly ever come across anyone who says Revivogen actually worked for them. At the same time, I've seen quite a few people who've said they've tried both Revivogen and Zix, and that Zix was actually effective at re-growing hair, whereas Revivogen was not.

This has happened too often for it to be coincidence, and I think there's a good explanation: I learned from actual experience using Zix, and from what others' experience has been as well, that adding too many things to it, or even 1 wrong ingredient, can really lessen, and even completely nullify its efficacy. ...That's essentially the main problem with the Revivogen formulation. (Along with possibly too miniscule a concentration of any given otherwise efficacious ingredient as well.)