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Effects of periodontitis on aortic insulin resistance in an obese rat model
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Effects of periodontitis on aortic insulin resistance in an obese rat model
As CS has mentioned in the past, oral pathology is a huge causative factor in disease. It's not just another symptom (ie., downstream effect). This means that improving oral health should be a major goal in all of our regimens. Not new information, but I just thought I'd hammer it in.
I wonder what are the mechanisms underlying this causation? I assume that the rats aren't getting any root canals, so that eliminates one major route of exposure to bacterial toxins. But periodontitis is characterized by constant bleeding of the gums, which means any toxins produced by oral bacteria would still be able to enter the bloodstream.
The combination of obesity and its associated risk factors, such as insulin resistance and inflammation, results in the development of atherosclerosis. However, the effects of periodontitis on atherosclerosis in an obese body remain unclear. The aim of the study was to investigate the effects of ligature-induced periodontitis in Zucker fatty rats on initiation of atherosclerosis by evaluating aortic insulin resistance. Zucker fatty rats (n=24) were divided into two groups. In the periodontitis group, periodontitis was ligature-induced for 4 weeks, whereas the control group was left unligated. After the 4-week experimental period, descending aorta was used for measuring the levels of lipid deposits, immunohistochemical analysis, and evaluation of gene expression. Levels of serum C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and insulin were also measured. Rats in the periodontitis group had significantly enhanced lipid deposits in the aorta, but not in the control group. Expression of suppressor of cytokine signaling 3, vascular cell adhesion molecule 1, reactive oxygen species, nitrotyrosine, and endothelin-1 in the periodontitis group was more intense than that in the control group. Significantly decreased levels of phosphatidylinositol 3-kinase (Pi3k) catalytic β-polypeptide (Pi3kcb), Pi3kp85, and insulin receptor substrate 1 and 2 were observed in the periodontitis group. Levels of serum CRP and TNF-α were significantly increased in the periodontitis group. Under insulin-stimulated conditions, aorta in the periodontitis group altered the Akt phosphorylation. Periodontitis in obesity induced the initial stage of atherosclerosis and disturbed aortic insulin signaling.
I wonder what are the mechanisms underlying this causation? I assume that the rats aren't getting any root canals, so that eliminates one major route of exposure to bacterial toxins. But periodontitis is characterized by constant bleeding of the gums, which means any toxins produced by oral bacteria would still be able to enter the bloodstream.
imprisoned-radical- Posts : 493
Join date : 2011-08-10
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