Beneficial effects of pumpkin seed oil as a topical hair growth promoting agent in a mice model.

Avicenna J Phytomed. 2019 Nov-Dec;9(6):499-504. doi: 10.22038/AJP.2019.13463.
Beneficial effects of pumpkin seed oil as a topical hair growth promoting agent in a mice model.
Hajhashemi V1, Rajabi P2, Mardani M1.
Author information
1
Department of Pharmacology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan university of Medical Sciences, Isfahan, Iran.
2
Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

OBJECTIVE:
Pumpkin (Cucurbita pepo L.) seed oil mainly consists of saturated and unsaturated fatty acids. Previously, it was reported that oral administration of pumpkin seed oil (PSO) improved hair growth in male pattern alopecia. This study aimed to evaluate hair promoting activity of topical PSO in an animal model.

MATERIALS AND METHODS:
Male Swiss mice (25-30 g) were used. Dorsal hair of mice (2 x 2.5 cm) was gently removed. Groups were treated as follows: (A) Intact control (did not receive testosterone) (B) Testosterone solution only (5% w/v); (C) Testosterone (5%) + PSO (5%); (D) Testosterone (5%) + PSO (10%) (E) Testosterone (5%) + minoxidil (2%). Application of drugs (100 µl) was done for six days a week, for 3 weeks. Observational and microscopic examinations were performed and results of different groups were compared.

RESULTS:
Topical application of testosterone significantly (p<0.01) prevented hair growth (compared with intact control). PSO (10%) increased hair growth score after 3 weeks and histopathological findings confirmed these results. After 3 weeks of treatment, the percentage of follicles in anagen phase was 95±4.6 and 44.4±15 for intact control and testosterone-only treated group, respectively. These percentages for PSO (10%) and minoxidil were 75±5.3 and 91.3±4.4, respectively and they could significantly (p<0.001) reverse the effects of testosterone.

CONCLUSION:
In conclusion, as topical application of PSO showed hair growth promotion, it might be regarded as a promising alternative for treatment of male pattern alopecia. Also, considering its composition, free fatty acids and minor components like phytoestrogens and vitamin E may have contributed to this effect.

Full study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823528/

I think they can get better results if the PSO was critically extracted with CO2 gas.

What are thoughts on Hairmetto? The second ingredient in the product is pumpkin seed oil.

Saw Palmetto Berries (CO2 extract/85-95% fatty acids), Cold-pressed Pumpkin Seed Oil, Cold-pressed Castor Seed Oil, Lavender essential oil, Cedarwood essential oil, Rosemary oil extract

I thought co2 extract would be better as well because the octa sabal plus product uses co2 pumpkin seed extract however it’s not available to purchase anywhere I can find