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Topical cacao with coconut oil
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Topical cacao with coconut oil
Have been trying out a topical cacao application using virgin, unrefined coconut oil as a carrier.
Although it's clear that cacao contains a plethora of things beneficial to hair, I also know that it contains small amounts of anandamide, which are counter-productive. Does anybody think anandamide in the context of cacao could possibly be harmful to hair growth? I have to doubt it, given the vast and complex array of other things it contains, but thought I'd bring it up just to see what others have to say.
Although it's clear that cacao contains a plethora of things beneficial to hair, I also know that it contains small amounts of anandamide, which are counter-productive. Does anybody think anandamide in the context of cacao could possibly be harmful to hair growth? I have to doubt it, given the vast and complex array of other things it contains, but thought I'd bring it up just to see what others have to say.
LightBringer- Posts : 16
Join date : 2011-09-14
Re: Topical cacao with coconut oil
I've been thinking about topical coconut oil. Lauric acid (the most abundant fatty acid in coconut oil) is supposed to be an effective inhibitor of both isoforms of 5AR. If I recall correctly, 5AR type 2 is preferentially expressed in the dermal papilla cells of hair follicles...this is where testosterone is converted into DHT. Research also indicates that saw palmetto's inhibition of 5AR is also due to its high lauric acid content.
J Pharm Pharmacol. 2007 Jul;59(7):995-9. Effects of coconut oil on testosterone-induced prostatic hyperplasia in Sprague-Dawley rats. de Lourdes Arruzazabala M, Molina V, Mas R, Carbajal D, Marrero D, Gonzalez V, Rodriguez E. Centre of Natural Products, National Centre for Scientific Research, Cubanacan, Playa, Havana City, Cuba.
Benign prostatic hyperplasia (BPH) is the benign uncontrolled growth of the prostate gland, leading to difficulty with urination. Saw palmetto lipid extracts (SPLE), used to treat BPH, have been shown to inhibit prostate 5a-reductase, and some major components, such as lauric, myristic and oleic acids also inhibit this enzyme. Coconut oil (CO) is also rich in fatty acids, mainly lauric and myristic acids. We investigated whether CO prevents testosterone-induced prostate hyperplasia (PH) in Sprague-Dawley rats. Animals were distributed into seven groups (10 rats each). A negative control group were injected with soya oil; six groups were injected with testosterone (3 mg kg(-1)) to induce PH: a positive control group, and five groups treated orally with SPLE (400 mg kg(-1)), CO or sunflower oil (SO) (400 and 800 mg kg(-1)). Treatments were given for 14 days. Rats were weighed before treatment and weekly thereafter. Rats were then killed and the prostates were removed and weighed. CO (400 and 800 mg kg(-1)), SPLE (400 mg kg(-1)) and SO at 800 mg kg(-1), but not at 400 mg kg(-1), significantly reduced the increase in prostate weight (PW) and PW:body weight (BW) ratio induced by testosterone (% inhibition 61.5%, 82.0%, 43.8% and 28.2%, respectively). Since CO and SPLE, but not SO, contain appreciable concentrations of lauric and myristic acids, these results could be attributed to this fact. In conclusion, this study shows that CO reduced the increase of both PW and PW:BW ratio, markers of testosterone-induced PH in rats.
Inhibition of type 1 and type 2 5alpha-reductase activity by free fatty acids, active ingredients of Permixon.
Raynaud JP, Cousse H, Martin PM.
Source
D.R.I.T.T., Université Pierre et Marie Curie, 4 Place Jussieu, Paris, France. jean-pierre.raynaud@admp6.jussieu.fr
Abstract
In different cell systems, the lipido-sterolic extract of Serenoa repens (LSESr, Permixon inhibits both type 1 and type 2 5alpha-reductase activity (5alphaR1 and 5alphaR2). LSESr is mainly constituted of fatty acids (90+/-5%) essentially as free fatty acids (80%). Among these free fatty acids, the main components are oleic and lauric acids which represent 65% and linoleic and myristic acids 15%. To evaluate the inhibitory effect of the different components of LSESr on 5alphaR1 or 5alphaR2 activity, the corresponding type 1 and type 2 human genes have been cloned and expressed in the baculovirus-directed insect cell expression system Sf9. The cells were incubated at pH 5.5 (5alphaR2) and pH 7.4 (5alphaR1) with 1 or 3nM testosterone in presence or absence of various concentrations of LSESr or of its different components. Dihydrotestosterone formation was measured with an automatic system combining HPLC and an on-line radiodetector. The inhibition of 5alphaR1 and 5alphaR2 activity was only observed with free fatty acids: esterified fatty acids, alcohols as well as sterols assayed were inactive. A specificity of the fatty acids in 5alphaR1 or 5alphaR2 inhibition has been found. Long unsaturated chains (oleic and linolenic) were active (IC(50)=4+/-2 and 13+/-3 microg/ml, respectively) on 5alphaR1 but to a much lesser extent (IC(50)>100 and 35+/-21 microg/ml, respectively) on 5alphaR2. Palmitic and stearic acids were inactive on the two isoforms. Lauric acid was active on 5alphaR1 (IC(50)=17+/-3 microg/ml) and 5alphaR2 (IC(50)=19+/-9 microg/ml). The inhibitory activity of myristic acid was evaluated on 5alphaR2 only and found active on this isoform (IC(50)=4+/-2 microg/ml). The dual inhibitory activity of LSESr on 5alpha-reductase type 1 and type 2 can be attributed to its high content in free fatty acids.
imprisoned-radical- Posts : 493
Join date : 2011-08-10
Re: Topical cacao with coconut oil
Use cacao butter and you do not need a carrier. The cacao butter molecules are actually smaller than almost all other oil and can get into pores and into the skin easier.
sublime9- Posts : 336
Join date : 2008-07-16
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