IH question about DHEA

Steven_Tyler wrote:CS- My DHEA levels are elevated, this can be good ?

Steven_Tyler wrote:CS- My DHEA levels are elevated, this can be good ?

J Am Acad Dermatol. 1987 Mar;16(3 Pt 1):571-3.
Serum elevation of dehydroepiandrosterone sulfate associated with male pattern baldness in young men.
Pitts RL.

Eighteen men aged 18 to 32 with rapidly progressive male pattern baldness had serum dehydroepiandrosterone sulfate and testosterone measured. Dehydroepiandrosterone sulfate levels were elevated in all patients, ranging from 340 to 730 micrograms/dl. The patients were otherwise healthy and serum testosterone levels were within normal limits.

A control group of men of similar age without hair loss had lower dehydroepiandrosterone sulfate levels ranging from 124 to 300 micrograms/dl (p less than 0.005).

The biochemistry of androgens, particularly dehydroepiandrosterone sulfate, suggests that adrenal hyperactivity may initiate alopecia in young men who are genetically susceptible.

Psychoneuroendocrinology. 2010 Aug;35(7):1055-62. doi: 10.1016/j.psyneuen.2010.01.006. Epub 2010 Feb 12.
Acute and chronic stress increase DHEAS concentrations in rhesus monkeys.
Maninger N1, Capitanio JP, Mason WA, Ruys JD, Mendoza SP.


Most studies on the stress-responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis have focused on glucocorticoids, while few studies have investigated the adrenal secretion of dehydroepiandrosterone sulfate (DHEAS), which is unique to primates. Monkeys were chair-restrained for 2h per day for seven consecutive days, and blood samples were collected upon placement in the chair, and at 15, 30, 60 and 120 min later. Like cortisol, DHEAS concentrations increased throughout the initial session of chair restraint (acute stress). Unlike the cortisol response, which decreased after repeated exposure to the stressor, the DHEAS response was sustained throughout the seventh session of restraint (chronic stress) and response to the seventh session of restraint did not differ from the DHEAS response to the initial session. Like cortisol, DHEAS concentrations showed a diurnal rhythm with higher concentrations in the morning compared to the evening and a decrease in response to dexamethasone (DEX) administration. After repeated exposure to the stressor, the suppression of DHEAS in response to dexamethasone was more complete, suggesting an increase in negative feedback sensitivity. These data show that DHEAS concentrations increase in response to both acute and chronic (repeated) stress and provide another measure of HPA activity that parallels cortisol during acute responses to stress but diverges in chronic or repeated stress.

TNT wrote:thx CS.

One more question. When i go for a morning blood test, should i measured DHEA, DHEA-S or both?

What is the best indicator?

droddy thank you too for the info...

shaftless wrote:So if too much DHEA can cause hair loss and is related to prolonged stress, how can we lower DHEA levels without using dexamethasone?

Renky wrote:Just to make sure I am understanding this... DHEA for a male near 40 years of age at a dosage rate of 3mg to 5mg a day is ok? I have several bottles that I was considering throwing out, but then I saw this thread and am now confused again.

I weight lift a LOT, so maybe DHEA would be good for me after all or at least until I finish the bottles (maybe a 3 month supply) and then switch over to magnesium oil?

Thanks.

Why You Should AVOID All Oral Hormone Preparations

There are many ways to "naturally" address bioidentical hormone replacement but one of the most common mistakes is to use oral hormones.

But if you swallow steroid hormones you seriously distort their natural metabolism. Swallowed hormones encounter potent stomach acids, and the hormones that survive this assault then move to your liver where they will be further broken down. Your liver screens all molecules that enter your blood stream, passing some onward, modifying or detoxifying others, and rejecting a few.

This routing of orally swallowed hormones is in sharp contrast to the way nature intended them to be distributed to your tissues.

If you swallow hormones, only 10-15 percent will eventually reach the target tissues and you will need to take an oral dose that is 500 percent higher than you need.

Many different metabolites are created in your liver when you swallow a DHEA supplement and any of these can produce unwanted side effects.

So if you or anyone you know currently use an oral DHEA supplement or any other oral hormone, I encourage you to strongly consider phasing them out and instead using a DHEA cream preparation that you administer trans mucosally.

TNT wrote:CS, what's your opinion about Dr mercola article regarding Oral Hormone Preparations? DHEA cream will be better?

Why You Should AVOID All Oral Hormone Preparations

There are many ways to "naturally" address bioidentical hormone replacement but one of the most common mistakes is to use oral hormones.

But if you swallow steroid hormones you seriously distort their natural metabolism. Swallowed hormones encounter potent stomach acids, and the hormones that survive this assault then move to your liver where they will be further broken down. Your liver screens all molecules that enter your blood stream, passing some onward, modifying or detoxifying others, and rejecting a few.

This routing of orally swallowed hormones is in sharp contrast to the way nature intended them to be distributed to your tissues.

If you swallow hormones, only 10-15 percent will eventually reach the target tissues and you will need to take an oral dose that is 500 percent higher than you need.

Many different metabolites are created in your liver when you swallow a DHEA supplement and any of these can produce unwanted side effects.

So if you or anyone you know currently use an oral DHEA supplement or any other oral hormone, I encourage you to strongly consider phasing them out and instead using a DHEA cream preparation that you administer trans mucosally.

http://articles.mercola.com/sites/articles/archive/2011/03/19/the-most-common-mistakes-in-bioidentical-hormone-replacement.aspx