Search
Check Out Our Sponsors
Latest topics
Are there any natural topicals (non antiandrogenic/5ar blocking) that anyone has used to at least help thicken their hair/turn vellous thicker/terminal?
4 posters
Page 1 of 1
Are there any natural topicals (non antiandrogenic/5ar blocking) that anyone has used to at least help thicken their hair/turn vellous thicker/terminal?
Just wondering if anything is out there?
sizzlinghairs- Posts : 812
Join date : 2011-05-21
Re: Are there any natural topicals (non antiandrogenic/5ar blocking) that anyone has used to at least help thicken their hair/turn vellous thicker/terminal?
cetirizine ?
cyproheptadine may work too
however the extra chlorine molecule in cetirizine is said to be problematic
https://www.hairlosstalk.com/interact/threads/exciting-results-from-minoxidil-pantostin-cetirizine.64012/
https://www.hairlosstalk.com/interact/threads/why-cetirizine-may-work.65983/
https://www.hairlosstalk.com/interact/threads/topical-cetrizine-for-hair-loss-instead-of-finasteride-propecia.63625/
cyproheptadine may work too
however the extra chlorine molecule in cetirizine is said to be problematic
https://www.hairlosstalk.com/interact/threads/exciting-results-from-minoxidil-pantostin-cetirizine.64012/
https://www.hairlosstalk.com/interact/threads/why-cetirizine-may-work.65983/
https://www.hairlosstalk.com/interact/threads/topical-cetrizine-for-hair-loss-instead-of-finasteride-propecia.63625/
iuyyighghghgkh- Posts : 1595
Join date : 2014-05-06
Re: Are there any natural topicals (non antiandrogenic/5ar blocking) that anyone has used to at least help thicken their hair/turn vellous thicker/terminal?
Think you've been around long enough to see a few topicals come and go with varying degrees of success
Joey Ramone- Posts : 165
Join date : 2010-02-02
Re: Are there any natural topicals (non antiandrogenic/5ar blocking) that anyone has used to at least help thicken their hair/turn vellous thicker/terminal?
True but I'm just trying to see what might currently be working. Trying to recondense current info
sizzlinghairs- Posts : 812
Join date : 2011-05-21
Re: Are there any natural topicals (non antiandrogenic/5ar blocking) that anyone has used to at least help thicken their hair/turn vellous thicker/terminal?
Honestly, could fill up a page of 5-AR inhibitors, the list is a "mile" long, although 5-AR is just one part of the problem.
That said, here is an interesting one.
http://amzn.to/2oasPgE
Biomed Pharmacother. 2017 Feb 26;89:438-446. doi: 10.1016/j.biopha.2017.02.036. [Epub ahead of print]
Hair growth promoting effect of white wax and policosanol from white wax on the mouse model of testosterone-induced hair loss.
Wang ZD1, Feng Y1, Ma LY1, Li X1, Ding WF1, Chen XM2.
White wax (WW) has been traditionally used to treat hair loss in China. However there has been no reporter WW and its extract responsible for hair growth-promoting effect on androgenetic alopecia. In this paper, we examined the hair growth-promoting effects of WW and policosanol of white wax (WWP) on model animal of androgenetic alopecia and the potential target cell of WW and WWP. WW (1, 10 and 20%) and WWP (0.5, 1 and 2%) were applied topically to the backs of mice. Finasteride (2%) was applied topically as a positive control. MTS assays were performed to evaluate cell proliferation in culture human follicle dermal papilla cells (HFDPCs). The inhibition of WW and WWP for 5α- reductase were tested in Vitro. Results showed more lost hairs were clearly seen in mice treated with TP only and TP plus vehicle. Mice which received TP plus WW and WWP showed less hair loss. WW and WWP showed an outstanding hair growth-promoting activity as reflected by the follicular length, follicular density, A/T ratio, and hair bulb diameter. The optimal treatment effect was observed at 10% WW and 1% WWP, which were better than 2% finasteride treatment. MTS assay results suggested that WW and WWP remarkably increased the proliferation of HFDPCs. Inhibitor assay of 5α- reductase showed that WW and WWP inhibited significantly the conversion of testosterone to dihydrotesterone, and the IC50 values of WW and WWP were higher than that of finasteride. In Conclusion, WW and WWP could act against testosterone-induced alopecia in mice, and they promoted hair growth by inhibiting 5α-reductase activity and HFDPCs proliferation. DPCs is the target cell of WW and WWP.
KEYWORDS:
5α- reductase; Androgenetic alopecia; Dermal papilla cells; Hair follicles; Policosanol from white wax; White wax
That said, here is an interesting one.
http://amzn.to/2oasPgE
Biomed Pharmacother. 2017 Feb 26;89:438-446. doi: 10.1016/j.biopha.2017.02.036. [Epub ahead of print]
Hair growth promoting effect of white wax and policosanol from white wax on the mouse model of testosterone-induced hair loss.
Wang ZD1, Feng Y1, Ma LY1, Li X1, Ding WF1, Chen XM2.
White wax (WW) has been traditionally used to treat hair loss in China. However there has been no reporter WW and its extract responsible for hair growth-promoting effect on androgenetic alopecia. In this paper, we examined the hair growth-promoting effects of WW and policosanol of white wax (WWP) on model animal of androgenetic alopecia and the potential target cell of WW and WWP. WW (1, 10 and 20%) and WWP (0.5, 1 and 2%) were applied topically to the backs of mice. Finasteride (2%) was applied topically as a positive control. MTS assays were performed to evaluate cell proliferation in culture human follicle dermal papilla cells (HFDPCs). The inhibition of WW and WWP for 5α- reductase were tested in Vitro. Results showed more lost hairs were clearly seen in mice treated with TP only and TP plus vehicle. Mice which received TP plus WW and WWP showed less hair loss. WW and WWP showed an outstanding hair growth-promoting activity as reflected by the follicular length, follicular density, A/T ratio, and hair bulb diameter. The optimal treatment effect was observed at 10% WW and 1% WWP, which were better than 2% finasteride treatment. MTS assay results suggested that WW and WWP remarkably increased the proliferation of HFDPCs. Inhibitor assay of 5α- reductase showed that WW and WWP inhibited significantly the conversion of testosterone to dihydrotesterone, and the IC50 values of WW and WWP were higher than that of finasteride. In Conclusion, WW and WWP could act against testosterone-induced alopecia in mice, and they promoted hair growth by inhibiting 5α-reductase activity and HFDPCs proliferation. DPCs is the target cell of WW and WWP.
KEYWORDS:
5α- reductase; Androgenetic alopecia; Dermal papilla cells; Hair follicles; Policosanol from white wax; White wax
_________________
My regimen
http://www.immortalhair.org/mpb-regimen
Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
Re: Are there any natural topicals (non antiandrogenic/5ar blocking) that anyone has used to at least help thicken their hair/turn vellous thicker/terminal?
Thanks for the link Immortal. I think my parentheses werent clear though.
I meant all topicals that do not have 5ar or antiandrogenic properties
I meant all topicals that do not have 5ar or antiandrogenic properties
sizzlinghairs- Posts : 812
Join date : 2011-05-21
Similar topics
» Has anyone had success, even moderate, with any natural non antiandrogenic topicals?
» Best way to turn vellus hairs terminal?
» Possible To Turn ACV (or other topicals) safely into gel/paste/lotion solution?
» Maintenance of optimised hair growth from viable terminal scalp hair follicles at baseline with oral finasteride in male pattern hair loss and first evidence of a "drug dependency" and a post-finasteride "rebound effect".
» Natural Topicals
» Best way to turn vellus hairs terminal?
» Possible To Turn ACV (or other topicals) safely into gel/paste/lotion solution?
» Maintenance of optimised hair growth from viable terminal scalp hair follicles at baseline with oral finasteride in male pattern hair loss and first evidence of a "drug dependency" and a post-finasteride "rebound effect".
» Natural Topicals
Page 1 of 1
Permissions in this forum:
You cannot reply to topics in this forum
|
|
Yesterday at 4:18 am by CausticSymmetry
» China is at it again
Yesterday at 4:07 am by CausticSymmetry
» Ways to increase adult stem cells
Mon May 06, 2024 5:40 pm by el_llama
» pentadecanoic acid
Sun May 05, 2024 10:56 am by CausticSymmetry
» Exosome Theory and Herpes
Fri May 03, 2024 3:25 am by CausticSymmetry
» Road to recovery - my own log of everything I'm currently trying for HL
Tue Apr 30, 2024 1:55 pm by JtheDreamer
» Medical Coder During C0NV!D
Sat Apr 27, 2024 4:00 pm by CausticSymmetry
» Potential Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells
Wed Apr 17, 2024 7:44 am by CausticSymmetry
» Breast Biopsy
Sun Apr 14, 2024 2:23 am by shaftless