Red Wine By Far Exceed The Biological Activity of Plain Resveratrol

Researchers Report Combined Molecules In Red Wine By Far Exceed The Biological Activity of Plain Resveratrol, Consistent With The Composition of Longevinex San Dimas, CA (March 10, 2009) – A recent CBS 60 Minutes TV program drew considerable attention to resveratrol (rez-vair-ah-trawl), a red wine molecule believed to largely be responsible for the French Paradox, the fact the French have far more people living beyond 100 years and exhibit a far lower mortality rate from heart disease than other people living in other developed countries, despite the high-calorie, high-fat diet in France.

Now researchers in Sweden report that the full array of molecules provided in red wine by far exceed the biological effects of plain resveratrol.

The results of the study are consistent with an earlier research study conducted among mice which showed that the combination of resveratrol, quercetin and rice bran phytate-IP6 (Longevinex) exerted a 9-times greater genomic effect than plain resveratrol or a calorie restricted diet. [Experimental Gerontology 2008 Sep; 43(9):859-66]

Researchers instilled various white and resveratrol-rich red wines as well as research-grade resveratrol into lab dishes with various types of cells (brain, lung, colon, cervical, kidney). Surprisingly researchers found the total array of molecules in red wine, but not white wine, produced a far greater biological effect than resveratrol alone. Furthermore, the beneficial effects were produced independently from alcohol or activation of the Sirtuin1 gene, considered a survival and longevity gene.

Only at higher concentrations did resveratrol cause unhealthy cells to die off (21%), compared to untreated cells (6%). Such a high concentration may produce long-term side effects in humans. But within 24 hours, red wine abolished virtually all (100%) the unhealthy cells. Red wine exerted its effect by disarming protective antioxidant systems.

Researchers caution that this is only a lab dish study and that the results are theoretical. But they seem to mirror the health-giving properties attributed red wine as observed in human populations in France.

The researchers speculate that “instead of a single molecule (like resveratrol) present in wine, … the combination of molecules in red wine … contribute result in a combined effect with positive outcome.”

Bill Sardi, spokesperson for Longevinex (long-jev-in-ex), says nutriceuticals have distinct advantages over drugs because they often provide an array of molecules, whereas the FDA prefers to approve single-molecule drugs.

“The synergism that nature produces, as seen in wine, may never be reproduced in prescription drugs for this reason,” says Sardi. “The development of a plain resveratrol drug may not be as productive as first imagined,” he says.

The patent-pending Longevinex formula provides an array of molecules including three found naturally in red wine – resveratrol, quercetin and ferulic acid. The dosage of these molecules in Longevinex is equivalent to what is provided in 3-5 glasses of red wine (180-300 mg), considered the safe and effective range observed in wine-drinking populations. [British Medical Journal 1991 September 7; 303(6802): 565–568] Longevinex is designed to deliver the health benefits of red wine without the alcohol, calories or sulfite preservatives.

The study was published in an early online edition (March 4, 2009) of Experimental Cell Research.

For more information about Longevinex, please visit www.longevinex.com

cpio - I've been receiving their emails for a while now, here is an excerpt from one of the more interest ones I received:

Researchers affiliated with the University of Wisconsin conducted a global gene array study comparing calorie restriction, plain resveratrol and a uniquely patented array of molecules (resveratrol, quercetin, IP6 rice bran) found in Longevinex. At doses of resveratrol 17-320 times lower than prior studies, Longevinex activated 9-fold more longevity genes than plain resveratrol or a calorie restricted diet. [Experimental Gerontology 2008 Sept; 43(9):859-66]

The alcohol component makes it tough to champion, but it has always been clear to me that resveratrol supps don't nearly match what wine has to offer. Even with the alcohol, it seems almost anti-candida which is remarkable in itself.

However, the mentioned supp may be an alternative, as I have not tried it. Looks interesting, as alcohol may be an issue for some.

Jarrow--sam-e seems to protect the liver well enough. I prefer it over NAC. And this is a protocol you may consider if you aim to drink wine daily.

make that nightly.

would it be beneficial to wash down a capsule of trans-resveratrol with a glass of red wine?

makes more sense to wash down turmeric with wine given the alleged synergy.

Might want to pass on the acetaldehyde filled alcohol. No hair promoting aspects about that...

In the current issue of Life Extension, which they curiously provide to me for free (it will up on line sometime next month)
they mention that Quercetin is the other not-mentioned enough polyphenol of red wine that has calorie restriction mimicking effects.

Life Extension says that Quercetin has been largely neglected in the public eye until recently.

In integrative medicine, it's been using it for a long time, mainly for allergies and for prostatitis/swelling).

However, it apparently is also good for cardiovascular disease, metabolic syndrome, etc.

IH,
what about gulping down a glass of red wine together with a cap of resveratrol and turmeric?is it ok?Don t we enjoy all the benefits coupled with the synergy as well?
Is it fine to have a glass of wine along w some supplements or the alcohol content make them useless?

edony - Moderate consumption of alcohol engenders longevity. It would make sense to get your resveratrol that way.

IH-
I'm sorry ,
what i wanted to ask is whether we can take supplements like curcumin/resv or EC and drink wine at the same time or the alcohol content renders them inactive ,so we should take the supps like an hour before or after wine consumption.

edony - Prior or with alcohol consumption would be fine. Alcohol does impair magnesium absorption however.

CausticSymmetry wrote:In the current issue of Life Extension, which they curiously provide to me for free (it will up on line sometime next month)
they mention that Quercetin is the other not-mentioned enough polyphenol of red wine that has calorie restriction mimicking effects.

Life Extension says that Quercetin has been largely neglected in the public eye until recently.

In integrative medicine, it's been using it for a long time, mainly for allergies and for prostatitis/swelling).

However, it apparently is also good for cardiovascular disease, metabolic syndrome, etc.

Have you seen this ?

http://www.reuters.com/article/pressRelease/idUS214320+09-Jan-2008+PRN20080109

"Quercetin can be mischaracterized," says Sardi, "since it allows
resveratrol more passes through the liver before it is finally conjugated
(attached to) sulfur and glucuronate molecules. Eventually, all resveratrol
is metabolized in the liver. Once bound to these molecules, resveratrol is,
for a time, not biologically active, but this process prolongs the life of
resveratrol in the blood circulation up to 9 hours. Otherwise, resveratrol
has a short half life (time it takes for 50% to degrade), about 14 minutes."

that link seems to be good because of quercetin and good amount of resve :

http://www.iherb.com/Life-Extension-Optimized-Resveratrol-250-mg-60-Veggie-Caps/10480?at=0


i also checked about a micronized resveratrol :

http://store.revgenetics.com/Micronized-Resveratrol-s/32.htm

i mean, The natural used to take 100 mg trans revse ONLY and saw results. then jumped to 200 mg a day. By rhe way can we know the prity in % fro the jarrow brand, ?

and it seems 400_500 mg is a better dosage for therapetic.

what do you guys think about that apart tsting it by ourselves....

Does all this imply that we should take grapeseed extract rather than resveratrol? I take both from www.swansonvitamins.com but I have completely overstocked on resveratrol, thinking that was the superior anti-oxidant.

Might want to pass on the acetaldehyde filled alcohol. No hair promoting aspects about that...

Jarrow--sam-e seems to protect the liver well enough. I prefer it over NAC. And this is a protocol you may consider if you aim to drink wine daily.

That's cool I have heard of sam-e but maybe I'll have to look into it again. I've been reading up on the negative effects of alcohol in hopes of being able to continue drinking it . Seems I always get a little more shedding after a night of booze.

NAC will help process the acetaldehyde quicker thus helping to reduce the effects. Glutamine is good to take while drinking because it will help prevent a "glutamine surge" while you are sleeping which is usually what causes the restless sleep while drinking. Also plenty of B vitamins, electrolytes and water. I've also heard ginseng was good but will have to look into that one some more.

As far as resveratrol is concerned I think that LEF brand will end up being the most cost conscious way to get the good stuff. 250mg w/ quercitin is pretty nice. That Longevinex would almost cost $2 per day at 200mg of resv. I have been taking a red wine extract from NSI but I see it only provides 37.5mg resv.

With the LEF brand you get 2 months worth for $35. Can't beat that right now.

Found some other options. Figure we can compile them all and figure which is the best deal.

Essence of Life - Jiva Resveratrol Healthy Heart Formula - 60 Vegetarian Capsules
$17.83 for 60 caps

Resveratrol & Quercetin, WELLCOR GUARD

$30 for 60 caps

200mg Resv (100mg trans-resv)
400mg Quercetin



http://www.wellcorsupplements.com/Resveratrol-Quercetin-WELLCOR-GUARD/M/B000VFW160.htm?traffic_src=froogle&utm_medium=organic&utm_source=froogle

http://www.cardiacwellness.com/product/WELL-0103P?meta=FRG&utm_source=GBASE&utm_medium=CPC&utm_content=&utm_campaign=

Anti-Aging Naturals: PURPLE LONGEVITY(TM), w/ Anti-Aging Grape Seed Extract, Grape Skin Extract and Resveratrol Extract!

$20.95 for 60 vegetarian capsules.

Resveratrol Extract (Std. 50% trans-resveratrol) 350mg
Grape Seed Extract (Std. 95% Polyphenols) 200 mg
Red Wine Extract 100mg, Grape Skin Extract (Std. 30% Polyphenols) 50 mg
Quercetin 50mg.
Other Ingredients: Cellulose, Magnesium Stearate.

http://www.remarkableresveratrol.com/AntiAging-Naturals-PURPLE-LONGEVITYTM-w-AntiAging/M/B000MZYOLO.htm?traffic_src=froogle&utm_medium=organic&utm_source=froogle

Planetary Herbals - Resveratrol with Red Wine Extract

$6.48 for 30 tabs

2 tablets contain:

Polygonum cuspidatum Root Standardized Extract 1 g
Yielding: Total Resveratrols 80 mg
Resveratrol 20 mg
Red Wine Extract 600 mg
Grape Seed Extract (Proanthodyn) 50 mg
Grape Skin Extract (20% polyphenols) 50 mg
Green Tea Leaf Ext. (95% polyphenols, 35% EGCG) 50 mg
Quercetin 20 mg

Suggested Use: 2 tablets twice daily.

http://www.amerilifevitamin.com/resveratrol-red-wine-extract-30-tabs-planetary.html

Meridian Naturals Resveratrol, 120 K-caps

$17.58 for 120 k-caps

Supplement Facts
Serving Size 1 kcap
Servings Per Container 120
Resveratrol (from Polygonum cuspidatum extract) (radix and rhizome) RESVERAPURE 100 mg *
Quercetin (as quercetin dihydrate) 30 mg
Other Ingredients:
Dicalcium phosphate, vegetable cellulose (K-CAPS capsule), magnesium stearate, silica and chlorophyll.

http://wholesalesupplementstore.com/meridianresverartol-resverapure-quercetin120kcaps.html?productid=meridianresverartol-resverapure-quercetin120kcaps&channelid=FROOG

I like my 200 mg of Resveratrol I get for pretty cheap (Now Brand) so I was looking around to see if anything else I'm taking happens to have Quercetin in it. I think I'll try a vitamin C product that has quercetin so I won't have to pay more resveratrol with Quercetin. Quercetin is quite cheap on its own also.

Check out this study:

http://www.ncbi.nlm.nih.gov/pubmed/19401153

Hey Hapyman, let me know if you find any inexpensive reseveratrol that is 98% extract or higher. The 50% stuff doesn't agree with me.

CS - Yeah, lot's of quercetin/bromelain supps to enhance resver...
http://www.iherb.com/Now-Foods-Quercetin-with-Bromelain-120-Vcaps/330?at=0

but, do you know the purity of now's resve ?

Jarrows seems to be approx 90% if i'm correct...


and another question : Acc to you, what would be the therapetic dosage to fully act with let's say a 400 mg curcumin sup bio LEF ?
because we can hear 100 to 500 mg here....