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A brand new look an old Mexican ulcer remedy

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Post  CausticSymmetry Fri Feb 06, 2009 12:49 pm

At first Stryphnodendron adstringens extract did not look interesting when considered this was a study on terminal hair removal. But a quick look at the abstract here shows it works by interfering with the androgen receptor sensitivity.

Since beard growth has a paradoxical effect in DHT mediated hair growth with scalp hair, Stryphnodendron adstringens bark extract or also known as Julianaceae (traditionally known as Cuachalalate) should have a very positive effect on scalp hair growth.

A quick search showed an old patent. The patent was for a hair tonic, very interesting some results in cases are reported in the patent:

http://www.freepatentsonline.com/5843421.html

Below is the abstract on the hair removal cream containing 5% Stryphnodendron adstringens bark extract.

J Eur Acad Dermatol Venereol. 2009 Feb 2.
Double-blind, randomized, placebo-controlled trial of a cream containing the Stryphnodendron adstringens (Martius) Coville bark extract for suppressing terminal hair growth.
Vicente RA, Leite E Silva VR, Baby AR, Velasco MV, Bedin V.

Brazilian Society of Aesthetic Medicine and Brazilian Society for Hair Studies, São Paulo, Brazil.

Background Excess of terminal hair can be defined as excessive hair that appears in male-like pattern in women. Some experts consider this condition as a result of an atypical relationship between levels of circulating androgens and sensitivity of androgen receptors in hair follicles to circulating androgens. Aims The aim of this research work was to evaluate the efficacy of a topical treatment for suppressing terminal hair growth of a cream containing 6.0% of the Stryphnodendron adstringens bark extract. Study design and subjects Study was randomized, double-blind and placebo-controlled. Subjects with excess of terminal hair were randomized to placebo and to the active treatment (cream with 6.0% of the extract). Evaluation was performed before and after 6 months, and subjects were photographed in each time. Clinical examination was carried out with the same physicians and in accordance with the Ferriman-Gallwey (FG) score. Results Benefits of the cream containing S. adstringens bark extract was observed in 60.98% (P < 0.001) of the subjects. FG score changed from 4 to 3 in the placebo group compared to 4-2 in the active. The cream suppressed the terminal hair growth and diminished the number of terminal hair. Subjects also described the reduction of skin hyperpigmentation, folliculitis and acne. Adverse events were not verified by physicians or patients. Conclusions The cream with 6.0% of the S. adstringens bark extract was effective on the reduction and on the reversion of the terminal hair excess, being considered a new promissory product for such finality. Conflicts of interest None declared.
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Post  zerx Fri Feb 06, 2009 1:35 pm

So in this study the extract was used topically to reduce terminal hair? Or was it really facial hair they are referring to?

Im going to assume its the facial hair and so how would this extract affect those of us with MPB?

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Post  CausticSymmetry Fri Feb 06, 2009 2:49 pm

zerx - Yes, this is more women to get rid of undesired facial hair.

Check out the patent, which shows it can help hair growth.

The bulk prices for this bark is very cheap. If an extract can be found, would be interesting to try.
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Post  edony Sat Feb 07, 2009 10:34 am

IH,
if you have a link for a cream to provide us with ... Wink
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Post  CausticSymmetry Sun Feb 08, 2009 10:15 am

edony - I haven't look around too much yet, but I did find the bark for really cheap. I'll keep looking, b/c that patent looked promising.
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