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Minoxidil may cause Hyperprolactinaemia
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Minoxidil may cause Hyperprolactinaemia
from Wikipedia: http://en.wikipedia.org/wiki/Hyperprolactinaemia#Symptoms
Hyperprolactinaemia may be caused by either disinhibition (e.g., compression of the pituitary stalk or reduced dopamine levels) or excess production from a prolactinoma (a pituitary gland adenoma tumour). A blood serum prolactin level of 1000–5000 mIU/L could be from either mechanism, but >5000 mIU/L is likely due to the activity of an adenoma with macroadenomas (large tumours over 10 mm diameter) whose levels of prolactin are up to 100,000 mIU/L. Hyperprolactinaemia inhibits gonadotropin-releasing hormone (GnRH) by increasing the release of dopamine from the arcuate nucleus of the hypothalamus (dopamine inhibits GnRH secretion), thus inhibiting gonadal steroidogenesis, which is the cause of many of the symptoms described below.
There is a suspicion that Minoxidil, a potassium channel agonist, may be related to the development of this disease. A two-year test with Minoxidil, under normal dosing parameters, was carried out on rats, which caused phaeochromocytomas in both males and females, and preputial gland adenomas in males.[2]
Hyperprolactinaemia may be caused by either disinhibition (e.g., compression of the pituitary stalk or reduced dopamine levels) or excess production from a prolactinoma (a pituitary gland adenoma tumour). A blood serum prolactin level of 1000–5000 mIU/L could be from either mechanism, but >5000 mIU/L is likely due to the activity of an adenoma with macroadenomas (large tumours over 10 mm diameter) whose levels of prolactin are up to 100,000 mIU/L. Hyperprolactinaemia inhibits gonadotropin-releasing hormone (GnRH) by increasing the release of dopamine from the arcuate nucleus of the hypothalamus (dopamine inhibits GnRH secretion), thus inhibiting gonadal steroidogenesis, which is the cause of many of the symptoms described below.
There is a suspicion that Minoxidil, a potassium channel agonist, may be related to the development of this disease. A two-year test with Minoxidil, under normal dosing parameters, was carried out on rats, which caused phaeochromocytomas in both males and females, and preputial gland adenomas in males.[2]
Paradox- Posts : 1496
Join date : 2008-07-14
Re: Minoxidil may cause Hyperprolactinaemia
bump, really cant believe nothing was discussed regarding this.
This is real, minoxidil does have this ability to cause prolactinomas.
This is real, minoxidil does have this ability to cause prolactinomas.
rio123- Posts : 60
Join date : 2013-02-27
Re: Minoxidil may cause Hyperprolactinaemia
A somewhat similar topic earlier this month, nevertheless, good post.
https://immortalhair.forumotion.com/t9678-high-prolactin-levels
https://immortalhair.forumotion.com/t9678-high-prolactin-levels
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Re: Minoxidil may cause Hyperprolactinaemia
now this is really interesting
http://www.thyroidscience.com/cases/jokic.wang.7.2011/jokic.wang.7.11.pdf
http://www.thyroidscience.com/cases/jokic.wang.7.2011/jokic.wang.7.11.pdf
rio123- Posts : 60
Join date : 2013-02-27
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