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http://www.trx2.com/
The recent discovery that potassium ion channels exist within the dermal papilla cells of human hair follicles provided a novel therapeutic target for researchers. Potassium ion channels have been implicated in a vast array of diseases ranging from Hepatitis C to Diabetes. These small pore-forming protein structures control the transport of potassium ions across the hair follicle’s cell membranes and are essential for maintaining the follicle’s full biological activity and function.

TRX2 scientists have demonstrated that as people experience hair loss the function of potassium channels within hair follicles diminishes. The effect is impaired membrane potential and interrupted ion transportation across the hair follicle’s cellular membranes – resulting in shrinking follicles and thinning hair.

Based on this research, TRX2 devised an elegant solution for stimulating hair growth on a molecular level: The rejuvenation of Potassium ion channels within hair follicles.

TRX2™ Molecular Hair Growth Supplement consists of natural substances that our body normally manufactures at sufficient levels in healthy hair, but at insufficient quantities as we experience hair loss. TRX2™ Molecular Hair Growth Supplement is a patent pending composition of normal metabolites that has been shown in laboratory experiments to reduce hair loss and reactivate the growth of hair follicles by:
1. Maintaining the membrane potential of hair follicles
2. Stimulating the de novo synthesis of potassium channels
3. Restoring potassium channel activity & functionality
4. Hyperpolarizing hair follicles

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TRX2™ promotes the hair follicles health and growth on a molecular level.

Boosting Energy Levels in Hair Follicles

In 2007 Foitzik et al. demonstrated that L-carnitine-L-tartrate promotes human hair growth; suggesting that L-carnitine stimulates scalp hair growth by up regulation of proliferation and down-regulation of apoptosis in follicular cells. TRX2™ products are the first to use Potassium and L-carnitine as part of their active ingredients for treating hair loss.

Research shows that L-carnitine stimulates hair growth by increasing the energy supply to the massively proliferating and insatiable anagen hair matrix – energy that is also required for the full biological activity of potassium channels in hair follicles.

Maintaining The Cell Membrane Potential of Hair Follicles

The membrane potential is the result of differing voltage between the inner and outer surfaces of a cell’s membrane. This process requires energy-driven potassium channels to move charge against a gradient. The dermal papilla cells of a healthy hair follicle (one containing sufficient potassium channels) have maximum membrane potential, sustaining the highest level of biological activity. However, as we experience hair loss, the membrane potential of these dermal papilla cells is diminished – a result of the impaired functionality of potassium channels within the hair follicle.

TRX2™ contains a compound that stimulates the synthesis of cardiolipin, a key component of the plasma membrane of dermal papilla cells in hair follicles. Cardiolipin plays a crucial role in maintaining the potential and integrity of hair follicle cell membranes. In short, TRX2™ provides the ideal lipid environment for potassium channels to flourish and function at peak efficiency.

Stimulating de novo Synthesis of Potassium Channels in Hair Follicles

The specific potassium channel found in human hair follicles has three major amino acid components: L-Leucine, Isoleucine and Valine (often referred to as BCAA).

By incorporating these components into our proprietary complex, our team has successfully found a way to replenish the membrane potential of hair cells and stimulate the synthesis of new potassium channels within hair follicles.

Stimulating Potassium Channel Activity & Functionality

Physiologically, the potassium channels of hair follicles are regulated by intracellular levels of nucleotides (e.g. ATP and ADP). Therefore, the electrical activity of a cell’s membrane is linked to its metabolism; a relationship that controls many diverse cellular functions.

The TRX2™ composition contains several sources of ATP. TRX2™ activates the transport of high-energy, food-derived products into the body’s mitochondria, where they are ultimately converted into ATP. This captured energy revitalizes potassium channels and is necessary for the regulation of ion transport across the cellular membranes.

Promotion of Hair Growth by Hyperpolarizing Hair Follicles

The TRX2™ complex, similar to the FDA approved treatment minoxidil (Rogaine™, Regaine™ or RIUP™), has several properties of known potassium channel openers. By hyperpolarizing the hair follicle’s plasma membranes, TRX2™ increases the size of shrunken follicles – resulting in longer, thicker and significantly more hair over the course of treatment.

The proprietary composition contains a natural compound, nicotinic acid, which is structurally related to minoxidil. In combination with the other TRX2™ compounds, nicotinic acid helps keep potassium channels open over time and supports the growth of healthy follicles.

TRX2™when used in combination with minoxidil

Topically applied minoxidil is one of the most widely used treatment options against male and female pattern hair loss. However, the clinical outcome of minoxidil based treatment regimen is often disappointing. In many cases the response rates are limited and efficacy decreases or disappears over time after continued use.

Originally minoxidil was developed as an oral antihypertensive drug, but a frequent side-effect was hair growth. The detailed mechanism of action of minoxidil on hair follicles is unclear. However, known as a potent potassium channel opener, it can be assumed that the drug targets the same tiny protein structures (potassium channels) TRX2™ does. Recent studies reveal that the ability of minoxidil to bind to potassium channels and function as an effective channel opener within human hair follicles varies among patients. This may be because every patient has different genetic susceptibilities.

TRX2™’s potassium channel activating nutrients work well in combination with existing minoxidil based treatment regimens such as Rogaine™ (Regaine™ or RIUP™). Our proprietary TRX2™ Hair Growth Complex has been shown in studies performed to date to boost overall efficacy of minoxidil treatment and to significantly improve the results even in those patients who have not previously experienced positive responses.

Uncovering the right formula of natural ingredients was a massive undertaking. Our dedicated team of scientists needed to design a variety of new research methods specifically for the purpose of targeting potassium ion channels for hair growth. After trying hundreds of different formulations of micro-nutrients, we centered upon the TRX2™ formula that includes a plethora of unique and powerful ingredients. This approach has allowed our company to succeed where others have failed. Our product works with your body to protect hair cells from damage and degradation. There are no side-effects, no complications and no hassle – just honest, noticeable results.

Listed below are some of the specific beneficial effects observed at the cellular level:
Cellular level

1. Increased membrane potential of dermal papilla cells in hair follicles
2. De novo synthesis of potassium channels
3. Enhanced potassium channel activity & functionality
4. Hyperpolarized hair follicles

This product is specifically designed for patients suffering from the early stages of hair loss (Norwood 1-4). Some of the benefits reported by those who regularly take three TRX2™ Molecular Hair Growth Supplement capsules per day include:
Visual level

* The cessation of hair loss
* The re-growth of hair follicles – including frontal region and temple area
* Visibly stronger & thicker hair shafts

hellwig wrote:Thanks for your response. Who's before and after pics?