Infant vitamin d supplementation and allergic conditions in adulthood

Infant vitamin d supplementation and allergic conditions in adulthood: northern Finland birth cohort 1966.
Hyppönen E, Sovio U, Wjst M, Patel S, Pekkanen J, Hartikainen AL, Järvelinb MR.

Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. e.hypponen@ich.ucl.ac.uk

Abstract
Allergen-induced secretion of Th2-type cytokines and IgE production have recently been reported to be increased in mice treated with 1,25(OH)(2)D, the active form of vitamin D. Our objective was to investigate whether vitamin D supplementation in infancy is associated with the risk of atopy, allergic rhinitis, and asthma. The Northern Finland Birth Cohort consists of all individuals in the two most northern provinces of Finland who were due to be born in 1966. Data on vitamin D supplementation during the first year of life was obtained in 1967. Current asthma and allergic rhinitis were reported at age 31 years (n = 7,648), and atopy determined by skin-prick test in a sub-sample still living in northern Finland or the Helsinki area (n = 5,007). The prevalence of atopy and allergic rhinitis at age 31 years was higher in participants who had received vitamin D supplementation regularly during the first year compared to others (OR 1.46, 95%CI 1.4-2.0, and OR 1.66, 95%CI 1.1-1.6, respectively). A similar association was observed for asthma (OR 1.35, 95%CI 0.99-1.. These associations persisted after adjustment for a wide range of behavioral and social factors (adjusted: OR 1.33 for all, P = 0.01 for atopy, P = 0.001 for allergic rhinitis, and P = 0.08 for asthma). We observed an association between vitamin D supplementation in infancy and an increased risk of atopy and allergic rhinitis later in life. Further study is required to determine whether these observations reflect long-term effects on immune regulation or differences in unmeasured determinants of vitamin D supplementation.

PMID: 15699498 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/15699498

Any way to get to the whole study? Abstract really isn't enough.

2009;89(1):28-32.

Does vitamin D intake during infancy promote the development of atopic allergy?
Bäck O, Blomquist HK, Hernell O, Stenberg B.

Department of Clinical sciences, Dermatology and Venereology, Lund University, Lund, Sweden. Ove.Back@med.lu.se

Abstract
The active metabolite of vitamin D, 1,25-(OH)2D3, has immunomodulatory properties in addition to its more established action on bone and calcium metabolism. Recently vitamin D has been proposed as one of several environmental factors responsible for the increase in atopic diseases during the last decades. The objective of this study was to determine whether the estimated dose of dietary vitamin D3 during the first year of life is associated with atopic diseases up to the age of 6 years. In a prospective birth cohort study 123 six-year-old children were investigated for the cumulative incidence of atopic dermatitis, allergic rhinitis or asthma by means of a postal questionnaire. Their vitamin D3 intake during infancy was recorded in a previous study and the relationship between lower or higher vitamin D3 intake and atopic illness later in childhood was assessed. Atopic manifestations were more prevalent in the group with higher intake of vitamin D3. Although small, this study supports previous investigations suggesting a role of vitamin D intake during infancy in the development of atopic allergy later in childhood. If these findings are confirmed in prospective controlled clinical trials, prevention through modified vitamin D3 supplementation in infancy could be discussed to reduce the burden of atopic illnesses.

PMID: 19197538 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/19197538

Again, there's really not enough information in the abstracts to evaluate the studies. I hope you're not basing conclusions off of them.

Only on a hair loss forum....


http://adv.medicaljournals.se/article/pdf/10.2340/00015555-0541

Sorry, fell victim to their shitty UI. As if reading the whole article was an "additional resource."

Interesting article... lots of holes in the study that the researchers acknowledge. I'd be interested to see where this goes.

empty wrote:Interesting article... lots of holes in the study that the researchers acknowledge. I'd be interested to see where this goes.

Sorry, can't edit. By "where this goes" I mean, in terms of future research.

Newborns yes perhaps, but research is quite the opposite for children:

Just one of many articles pointing towards some studies:

http://www.reuters.com/article/idUSTRE62I3MK20100319

But keep trying jdp, I find your obstinacy to be quite entertaining, if not, downright funny.