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Emblica, alot of research goes into this ayevedic herb
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Emblica, alot of research goes into this ayevedic herb
I got two botttles of amlaka (emblica) dirtcheap stuff, and alot of promising
research into this herb can be found on pubmed ..
research into this herb can be found on pubmed ..
Amaranthaceae- Posts : 1368
Join date : 2008-07-15
Location : Copenhagen
Re: Emblica, alot of research goes into this ayevedic herb
J Ethnopharmacol. 2008 Sep 2;119(1):53-7. Epub 2008 Jun 6.Click here to read
Amla (Emblica officinalis Gaertn.) extract promotes procollagen production and inhibits matrix metalloproteinase-1 in human skin fibroblasts.
Fujii T, Wakaizumi M, Ikami T, Saito M.
Institute for Health Sciences, MIKI Corporation, 12-4, Naruohama 3, Nishinomiya 663-8142, Hyogo, Japan. fujii@mikiprune.co.jp
AIM OF THE STUDY: Emblica officinalis Gaertn., commonly known as amla, is a rich dietary source of vitamin C, minerals and amino acids, and also contains various phenolic compounds. Amla extract is also known to exhibits potent antioxidant properties and to provide protection for human dermal fibroblasts against oxidative stress, and therefore it is thought to be useful for natural skin care. In this study, we investigated the effects of amla extract on human skin fibroblasts, especially for production of procollagen and matrix metalloproteinases (MMPs), in vitro. MATERIALS AND METHODS: Mitochondrial activity of human skin fibroblasts were measured by WST-8 assay. Quantification of procollagen, MMPs, and Tissue inhibitor of metalloproteinase-1 (TIMP-1) released from human skin fibroblasts were performed by immunoassay technique. RESULTS AND CONCLUSIONS: Amla extract stimulated proliferation of fibroblasts in a concentration-dependent manner, and also induced production of procollagen in a concentration- and time-dependent manner. Conversely, MMP-1 production from fibroblasts was dramatically decreased, but there was no evident effect on MMP-2. TIMP-1 was significantly increased by amla extract. From these results, it appears that amla extract works effectively in mitigative, therapeutic and cosmetic applications through control of collagen metabolism.
Amla (Emblica officinalis Gaertn.) extract promotes procollagen production and inhibits matrix metalloproteinase-1 in human skin fibroblasts.
Fujii T, Wakaizumi M, Ikami T, Saito M.
Institute for Health Sciences, MIKI Corporation, 12-4, Naruohama 3, Nishinomiya 663-8142, Hyogo, Japan. fujii@mikiprune.co.jp
AIM OF THE STUDY: Emblica officinalis Gaertn., commonly known as amla, is a rich dietary source of vitamin C, minerals and amino acids, and also contains various phenolic compounds. Amla extract is also known to exhibits potent antioxidant properties and to provide protection for human dermal fibroblasts against oxidative stress, and therefore it is thought to be useful for natural skin care. In this study, we investigated the effects of amla extract on human skin fibroblasts, especially for production of procollagen and matrix metalloproteinases (MMPs), in vitro. MATERIALS AND METHODS: Mitochondrial activity of human skin fibroblasts were measured by WST-8 assay. Quantification of procollagen, MMPs, and Tissue inhibitor of metalloproteinase-1 (TIMP-1) released from human skin fibroblasts were performed by immunoassay technique. RESULTS AND CONCLUSIONS: Amla extract stimulated proliferation of fibroblasts in a concentration-dependent manner, and also induced production of procollagen in a concentration- and time-dependent manner. Conversely, MMP-1 production from fibroblasts was dramatically decreased, but there was no evident effect on MMP-2. TIMP-1 was significantly increased by amla extract. From these results, it appears that amla extract works effectively in mitigative, therapeutic and cosmetic applications through control of collagen metabolism.
Amaranthaceae- Posts : 1368
Join date : 2008-07-15
Location : Copenhagen
Re: Emblica, alot of research goes into this ayevedic herb
: J Cosmet Sci. 2009 Jul-Aug;60(4):395-404.Links
Type I pro-collagen promoting and anti-collagenase activities of Phyllanthus emblica extract in mouse fibroblasts.
Chanvorachote P, Pongrakhananon V, Luanpitpong S, Chanvorachote B, Wannachaiyasit S, Nimmannit U.
Department of Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
As part of an ongoing search for the novel pharmacological activities of Phyllanthus emblica, the present study has shown its type I collagen promoting and anti-collagenase effects on primary mouse fibroblast cells. At a concentration of 0.1 mg/ml, emblica extract significantly increased the type I pro-collagen level up to 1.65-fold, and 6.78-fold greater than that of an untreated control, determined by immunocytochemistry and Western blot analysis, respectively. Emblica extract caused an approximately 7.75-fold greater type I pro-collagen induction compared to the known herbal collagen enhancer asiaticoside at the same treatment concentration (0.1 mg/ml). Moreover, emblica extract inhibited collagenase activity in a dose-dependent manner. Maximal inhibition was observed (78.67 +/- 3.51%) at a concentration of 1 mg/ml. In summary, emblica extract has a promising pharmacological effect that benefits collagen synthesis and protects against its degradation and could be used as a natural anti-aging ingredient.
Type I pro-collagen promoting and anti-collagenase activities of Phyllanthus emblica extract in mouse fibroblasts.
Chanvorachote P, Pongrakhananon V, Luanpitpong S, Chanvorachote B, Wannachaiyasit S, Nimmannit U.
Department of Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
As part of an ongoing search for the novel pharmacological activities of Phyllanthus emblica, the present study has shown its type I collagen promoting and anti-collagenase effects on primary mouse fibroblast cells. At a concentration of 0.1 mg/ml, emblica extract significantly increased the type I pro-collagen level up to 1.65-fold, and 6.78-fold greater than that of an untreated control, determined by immunocytochemistry and Western blot analysis, respectively. Emblica extract caused an approximately 7.75-fold greater type I pro-collagen induction compared to the known herbal collagen enhancer asiaticoside at the same treatment concentration (0.1 mg/ml). Moreover, emblica extract inhibited collagenase activity in a dose-dependent manner. Maximal inhibition was observed (78.67 +/- 3.51%) at a concentration of 1 mg/ml. In summary, emblica extract has a promising pharmacological effect that benefits collagen synthesis and protects against its degradation and could be used as a natural anti-aging ingredient.
Amaranthaceae- Posts : 1368
Join date : 2008-07-15
Location : Copenhagen
Re: Emblica, alot of research goes into this ayevedic herb
Amla, the fruit of the redcurrant bush, has been traditionally used in ayurvedic medicine for thousands of years to treat numerous diseases. Amla’s benefits, such as its ability to treat respiratory or intestinal problems, are largely due to the fruit’s high tannin content. Its polyphenols are also known for their many health benefits, such as reducing blood sugar and lipids, stimulating circulation and blocking the action of carcinogens, thus helping to fight the effects of ageing.
Most of the research on amla’s properties has focused on those of the tannins, powerful antioxidants. In particular, studies have shown that amla extract :
• is a powerful antioxidant which :
• is a potent free radical scavenger,
• is able to stimulate the body’s enzymatic antioxidant system : when given to rats subjected to stress, amla’s tannin extracts normalised antioxidant enzyme activity in the animals’ brains and reduced lipid peroxidation,
• may prevent age- and oxidative stress-related kidney disease,
• reduces various markers of oxidative stress, when given to diabetic rats,
• increases antioxidant levels in the liver and reduces cytotoxins ;
• has immuno-modulatory properties and, in particular, stimulates cytotoxic activity of NK (natural killer) cells ;
• provides protection against heavy metal toxicity :
• prevents DNA and cell damage caused by arsenic poisoning,
• prevents cell damage from the toxic effects of lead, aluminium, nickel, cadmium and chromium ;
• reduces cholesterol levels by inhibiting its production and stimulating its breakdown :
• according to in vitro and in vivo studies, reduces total- and LDL-cholesterol levels in a dose-dependent manner : it also decreases lipid peroxidation, thus preventing atherosclerosis,
• lowers cholesterol levels when taken over a period 28 days, according to one study ;
• may be effective at delaying development of hyperglycema-induced cataracts in diabetics by inhibiting production of aldose reductase, according to one in vitro study and one study on rats ;
• inhibits cancer cell proliferation (in gastric, uterine or breast cancer) : amla extract has, in particular, demonstrated chemopreventive properties on skin tumours in albino mice ;
• protects the stomach wall from ethanol-induced decreases in mucous and inhibits the development of gastric lesions ;
• reduces ethanol-induced liver damage in rats ;
• protects the stomach wall from the harmful effects of certain drugs known to cause ulcers.
Amalaki (Emblica Officinalis) is a small tree that’s native to tropical southeastern Asia, including India, Pakistan, Sri Lanka, Malaysia and the Mascarene Islands. Also known as Indian gooseberry, Amalaki bears a small round fruit (about ½ to 1” in diameter) that’s one of nature’s richest sources of antioxidants. In fact, its juice has about 20 times more vitamin C than orange juice. Research has shown that the fruit has both antibacterial and antiviral properties.
In the Ayurvedic healing tradition, Amalaki is considered the most powerful rejuvenating medicine. In Sanskrit, Amalaki means “the sustainer,” and it’s used to nourish the blood, skin, liver and bones. It’s frequently recommended for a wide variety of debilitating conditions.
Amalaki fruit is extremely nutritious and well known among Ayurvedic practitioners for being the only food that contains five of the six essential tastes (rasas): sour, sweet, bitter, pungent and astringent. It lacks only the salty taste. This is a valuable property because in Ayurveda, a balanced diet needs to contain all six tastes at every meal to create optimal health.
Most of the research on amla’s properties has focused on those of the tannins, powerful antioxidants. In particular, studies have shown that amla extract :
• is a powerful antioxidant which :
• is a potent free radical scavenger,
• is able to stimulate the body’s enzymatic antioxidant system : when given to rats subjected to stress, amla’s tannin extracts normalised antioxidant enzyme activity in the animals’ brains and reduced lipid peroxidation,
• may prevent age- and oxidative stress-related kidney disease,
• reduces various markers of oxidative stress, when given to diabetic rats,
• increases antioxidant levels in the liver and reduces cytotoxins ;
• has immuno-modulatory properties and, in particular, stimulates cytotoxic activity of NK (natural killer) cells ;
• provides protection against heavy metal toxicity :
• prevents DNA and cell damage caused by arsenic poisoning,
• prevents cell damage from the toxic effects of lead, aluminium, nickel, cadmium and chromium ;
• reduces cholesterol levels by inhibiting its production and stimulating its breakdown :
• according to in vitro and in vivo studies, reduces total- and LDL-cholesterol levels in a dose-dependent manner : it also decreases lipid peroxidation, thus preventing atherosclerosis,
• lowers cholesterol levels when taken over a period 28 days, according to one study ;
• may be effective at delaying development of hyperglycema-induced cataracts in diabetics by inhibiting production of aldose reductase, according to one in vitro study and one study on rats ;
• inhibits cancer cell proliferation (in gastric, uterine or breast cancer) : amla extract has, in particular, demonstrated chemopreventive properties on skin tumours in albino mice ;
• protects the stomach wall from ethanol-induced decreases in mucous and inhibits the development of gastric lesions ;
• reduces ethanol-induced liver damage in rats ;
• protects the stomach wall from the harmful effects of certain drugs known to cause ulcers.
Amalaki (Emblica Officinalis) is a small tree that’s native to tropical southeastern Asia, including India, Pakistan, Sri Lanka, Malaysia and the Mascarene Islands. Also known as Indian gooseberry, Amalaki bears a small round fruit (about ½ to 1” in diameter) that’s one of nature’s richest sources of antioxidants. In fact, its juice has about 20 times more vitamin C than orange juice. Research has shown that the fruit has both antibacterial and antiviral properties.
In the Ayurvedic healing tradition, Amalaki is considered the most powerful rejuvenating medicine. In Sanskrit, Amalaki means “the sustainer,” and it’s used to nourish the blood, skin, liver and bones. It’s frequently recommended for a wide variety of debilitating conditions.
Amalaki fruit is extremely nutritious and well known among Ayurvedic practitioners for being the only food that contains five of the six essential tastes (rasas): sour, sweet, bitter, pungent and astringent. It lacks only the salty taste. This is a valuable property because in Ayurveda, a balanced diet needs to contain all six tastes at every meal to create optimal health.
Amaranthaceae- Posts : 1368
Join date : 2008-07-15
Location : Copenhagen
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