Para rubber seed oil: the safe and efficient bio-material for hair loss treatment

J Cosmet Dermatol
. 2020 Nov 13. doi: 10.1111/jocd.13843. Online ahead of print.
Para rubber seed oil: the safe and efficient bio-material for hair loss treatment
Nattaya Lourith 1 2, Mayuree Kanalayavattanakul 1 2, Puxvadee Chaikul 1 2
Affiliations expand
PMID: 33185310 DOI: 10.1111/jocd.13843

Objectives: Para rubber (Hevea brasiliensis (Willd. ex A. Juss.) Müll. Arg.)) is the important crop of the world. It has been vastly used in biomedical products. However, it's pharmacologically application besides the latex sparely to be explored especially the seed. Cellular biological activities of the standardized para rubber seed oil for hair loss treatment were therefore assessed.

Methods: Para rubber seed oil was prepared and standardized using GC/MS on the basis of its pharmacologically active fatty acids. The oil was safety assessed in human dermal papilla and DU-145 human prostate carcinoma. Cellular antioxidant activity was determined as well as proliferation stimulating efficacy and inhibitory effect against 5α-reductase.

Results: Fatty acids of cutaneous benefits, oleic acid was majorly detected in the oil, and followed by linoleic, palmitic and stearic acids. The standardized para rubber seed oil was proved to be safe on human follicle dermal papilla and DU-145 human prostate carcinoma at the concentration of 0.1-50 and 0.1-100 µg/ml, respectively. The standardized para rubber seed oil stimulated the cell proliferation and posed cellular antioxidant activity in human dermal papilla at a comparable potency to minoxidil, dutasteride and vitamin C at the same tested concentration. In addition, the standardized para rubber seed oil inhibited 5α-reductase as examined in DU-145 human prostate carcinoma, although at a lesser degree than the standards at the same tested concentration.

Conclusions: The standardized para rubber seed oil is evidenced as the safe and efficient bio-oil to be used for hair growth stimulating or reduce/suppress hair loss treatment.

Keywords: biological activity; cell culture; fatty acid; hair; para rubber; seed oil.

Was looking at this study just a few weeks ago, probably no coincidence. 

https://www.jbc.org/content/288/10/7117.long