Search
Check Out Our Sponsors
Latest topics
Clinical and histological study of permanent alopecia after bone marrow transplantation.
Page 1 of 1
Clinical and histological study of permanent alopecia after bone marrow transplantation.
An Bras Dermatol. 2015 Dec;90(6):814-21. doi: 10.1590/abd1806-4841.20154013.
Clinical and histological study of permanent alopecia after bone marrow transplantation.
Basilio FM1, Brenner FM1, Werner B1, Rastelli GJ1.
BACKGROUND:
Permanent alopecia after bone marrow transplantation is rare, but more and more cases have been described, typically involving high doses of chemotherapeutic agents used in the conditioning regimen for the transplant. Busulfan, classically described in cases of irreversiblealopecia, remains associated in recent cases. The pathogenesis involved in hair loss is not clear and there are few studies available. In addition to chemotherapeutic agents, another factor that has been implicated as a cause is chronic graft-versus-host disease. However, there are no histopathological criteria for defining this diagnosis yet.
OBJECTIVE:
the study aims to evaluate clinical and histological aspects in cases of permanent alopecia after bone marrow transplantation, identifying features of permanent alopecia induced by myeloablative chemotherapy and alopecia as a manifestation of chronic graft-versus-host disease.
METHODS:
data were collected from medical records of 7 patients, with description of the clinical features and review of slides and paraffin blocks of biopsies.
RESULTS:
Two distinct histological patterns were found: one similar to androgenetic alopecia, non-scarring pattern, and other similar to lichen planopilaris, scarring alopecia.
CONCLUSION:
The first pattern corroborates the literature cases of permanent alopecia induced by chemotherapeutic agents, and the second is compatible with manifestation of chronic graft-versus-host disease on scalp, that has never been described yet. The results contribute to the elucidation of the factors involved in these cases, including the development of therapeutic methods.
Full Study: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689068/
Clinical and histological study of permanent alopecia after bone marrow transplantation.
Basilio FM1, Brenner FM1, Werner B1, Rastelli GJ1.
BACKGROUND:
Permanent alopecia after bone marrow transplantation is rare, but more and more cases have been described, typically involving high doses of chemotherapeutic agents used in the conditioning regimen for the transplant. Busulfan, classically described in cases of irreversiblealopecia, remains associated in recent cases. The pathogenesis involved in hair loss is not clear and there are few studies available. In addition to chemotherapeutic agents, another factor that has been implicated as a cause is chronic graft-versus-host disease. However, there are no histopathological criteria for defining this diagnosis yet.
OBJECTIVE:
the study aims to evaluate clinical and histological aspects in cases of permanent alopecia after bone marrow transplantation, identifying features of permanent alopecia induced by myeloablative chemotherapy and alopecia as a manifestation of chronic graft-versus-host disease.
METHODS:
data were collected from medical records of 7 patients, with description of the clinical features and review of slides and paraffin blocks of biopsies.
RESULTS:
Two distinct histological patterns were found: one similar to androgenetic alopecia, non-scarring pattern, and other similar to lichen planopilaris, scarring alopecia.
CONCLUSION:
The first pattern corroborates the literature cases of permanent alopecia induced by chemotherapeutic agents, and the second is compatible with manifestation of chronic graft-versus-host disease on scalp, that has never been described yet. The results contribute to the elucidation of the factors involved in these cases, including the development of therapeutic methods.
Full Study: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689068/
_________________
My regimen
http://www.immortalhair.org/mpb-regimen
Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
Similar topics
» Do Kimchi and Cheonggukjang Probiotics as a Functional Food Improve Androgenetic Alopecia? A Clinical Pilot Study.
» The annual changes of clinical manifestation of androgenetic alopecia clinic in korean males and females: a outpatient-based study.
» Bone Marrow Donation
» Animal Bone Marrow / Broth || Leaky Gut Discussion
» A randomized evaluator blinded study of effect of microneedling in androgenetic alopecia: a pilot study
» The annual changes of clinical manifestation of androgenetic alopecia clinic in korean males and females: a outpatient-based study.
» Bone Marrow Donation
» Animal Bone Marrow / Broth || Leaky Gut Discussion
» A randomized evaluator blinded study of effect of microneedling in androgenetic alopecia: a pilot study
Page 1 of 1
Permissions in this forum:
You cannot reply to topics in this forum
Today at 7:01 am by Atlas
» zombie cells
Sat May 11, 2024 6:54 am by CausticSymmetry
» Sandalore - could it be a game changer?
Wed May 08, 2024 9:45 pm by MikeGore
» *The first scientific evidence in 2021 that viruses do not exist*
Tue May 07, 2024 4:18 am by CausticSymmetry
» China is at it again
Tue May 07, 2024 4:07 am by CausticSymmetry
» Ways to increase adult stem cells
Mon May 06, 2024 5:40 pm by el_llama
» pentadecanoic acid
Sun May 05, 2024 10:56 am by CausticSymmetry
» Exosome Theory and Herpes
Fri May 03, 2024 3:25 am by CausticSymmetry
» Road to recovery - my own log of everything I'm currently trying for HL
Tue Apr 30, 2024 1:55 pm by JtheDreamer