Histogen cure to baldness: Injection of human serum albumin proteins grown under hxpoxia and suspension

If you didn't check the results from Histogen at this years World Congress for Hair Research - check em out they are quite impressive and they seem confident after trails that this is an effective treatment. They have actually seen the best results with men over 40 and they've got extremely good efficacy in the temporal recession area. Histogen has now replaced animal bovine proteins (because of allergies) with human serum albumin proteins.

Quick summary of the science behind HSC:
"Histogen’s lead product application is Hair Stimulating Complex (HSC), which is a soluble formulation developed as an injectable for hair regrowth. The cell conditioned media that comprises HSC is produced by neonatal cells grown under simulated embryonic conditions of hypoxia (3-5% oxygen) and suspension. Under these conditions, the cells become multipotent and there is a significant upregulation of growth factors which have been shown to be important in hair viability. The proteins within HSC, including KGF, VEGF, and follistatin, are involved in signaling stem cells in the body, and have been shown to be key in hair formation and the stimulation of resting hair follicles. Follistatin in particular has been linked to hair follicle stem cell proliferation."

HSC showed in vitro WNT activity and it contains three growth factors that they think are the most important and all of them are present in very large quantities in this cell serum: Follistatin (BMP-4 antagonist - only then are the stem cells "allowed" to start proliferate), KGF=FGF7 (converts vellus hair to terminal) and VEGF (stimulates blood flow and new blood vessels). They have also mentioned Stem Cell Factor that acts on CD34+ progenitor cells. Basically they are bringing back to the scalp all of the growth factors that you were able to make yourself when you were growing your hair normally. They basically lift the BMP-4 block, once that happens this starts the entire cascade of the events - it's like a domino effect that continues over time.

So basically in the meantime, we can try to replicate the formula with side effects free supps and topicals and address this four points:

1. Increase the stem cells/progenitor cells and mimic hypoxia to achieve embryonic condition (this is critical!): for hypoxia and stem cells we can use Stemoxydine; for bovine embryonic stem cells we could use Colostrum as Histogen got good results with bovine serum in the trails; and maybe something like Stem-Kine product which had shown increased stem/progenitor cells in the blood (Vitamin D3 2000IU and Proprietary blend: 1400mg* L. fermentum extract; Ellagic Acid 40% & Beta 1,3 Glucan); Red Seaweed Extract, Valerian Root Extract, Probiotics for stem/progenitor cells.

2. Increase growth factors (FGF7, VEGF): Adenosine, Magnesium (topically or orally), Dermaneedling.

3. Antagonize BMP-4 (the key for success!): Follistatin is BMP-4 antagonist, so to replicate this we could add Vitamin K2 (and co-factors) as it does the same as Follistatin.

4. Increase WNT signaling: Curcumin and other Antioxidants, Vit D3 and A, Brewer's Yeast and Vit B12; Lithium/DMSO?, Dermaneedling, Vitamin C, Iodine and Brewer's Yeast, Vitamin K2, Coconut oil for DKK-1 antagonism and add anything else that helps with Lp(a).

so, pretty much vpa, Lithium, stemox and dermarolling, take care of all these.

bogv51 wrote:so, pretty much vpa, Lithium, stemox and dermarolling, take care of all these.

Well if you search the forums you will see that none of them did much on their own for people who tried them, except for few lucky guys who massacred their scalp with Dermarollers. Stemoxydine definitely works but sadly only on existing hairs, Lithium and VPA are questionable in my opinion - lots of people had experimented with them with nothing to report. But I think If you to combine all of them together and first break the PGD2 lock then yes the regrowth could potentially occur.

Adipose stem cell injections available right now in Switzerland through Kerastem for 6 k if I had cash I would do this in mean time to increase stem cell activity I've started half pound of blueberries per day mixed in smoothie going on 3 weeks now icariin 60 percent 1 gram per day increases multiple stem cell lines as well as aloemannan from premier research labs containing 15 percent acemannan known to proliferate stem cells as well also started tocomin supra bio 200 mg per day bout a week or so ago good for telomerase and possible stem cell activation as well