So which is it? Testosterone or PGD2?

All along we've been told that dihydrotestosterone was the culprit for hairloss. And now it's been confirmed (back in march) that pgd2 is the main problem. Can we forget about blocking hormones and concentrate on the pgd2? Is pdg2 and dihydrotest* somehow working together? Unless they can come up with a cheap version of equol we may just have to wait for the pdg2 blocking drugs that are now in trials. How long do you think we have to wait for them to hit the market?

it's both. transcript involved in pgd production is a testosterone sensitive one.

Yea its both, im not a doctor or anything but I think the DHT is the final part of the chain.

For example if your wall is damp and the plaster falls off, the DHT would be behind the plaster, so you put a lining behind the plaster and you have a nice wall again (DHT inhibitor). BUT behind the plaster, behind the lining the bricks are still damp (PGD2) and eventually will degrade the lining and your plaster will fall off again. So by fixing the PGD2 we make the DHT less effective..... I think.

DHT is probably just the tip of the iceberg, PGD2 is probably just the surface underneath the tip, there will be something behind that PGD2 no doubt. IMO it has to go deeper into hormonal balance over all well being of the body. I cant help but think that MPB is just a symptom of an underlying problem. For example I personally feel that my estrogen levels are higher than they should be, thats just by looking at smyptoms etc but it fits perfectly.

Instead of baseless speculation, I suggest taking the time out to learn about estrogen and hair:

http://edrv.endojournals.org/content/27/6/677.full.pdf+html

Guysssss,

Will there ever be a effective cure for baldness??????

Tight Galea, DHT, PGD2,Expansion of skull, Harmones....

will they ever find one?????????


How longggggggggggggggggggggg to waitttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttt?

[quote]Unless they can come up with a cheap version of equol we may just have to wait for the pdg2 blocking drugs that are now in trials. How long do you think we have to wait for them to hit the market?[/quote]

we dont have to wait. they have the drugs now, but they r used as anti histamines.
As far as i know they r not trialing new drugs to block PGD2, they are just going to make topicals of the existing drugs such as zyrtec (cetrizine). I have my doubts wether it will work though, elevated PGd2 in balding scalps doesnt neccessarily mean if we block it, it will cure baldness, there could be hundreds of chemicals elevated in balding scalps.

if interested there is people on hairlosshelp currently trying to block PGD2 topically.

At hairlosshelp they havent started using PGD2 blocker yet, they have only just managed to get it sourced and made. They have began buying it but not using it yet.

Well crap! If cetrizine is already available over-the-counter in Reactine and Zyrtec...then why can't we just crush a few pills and dissolve them in a bottle of rogaine?

rofl wrote:

Unless they can come up with a cheap version of equol we may just have to wait for the pdg2 blocking drugs that are now in trials. How long do you think we have to wait for them to hit the market?

we dont have to wait. they have the drugs now, but they r used as anti histamines.
As far as i know they r not trialing new drugs to block PGD2, they are just going to make topicals of the existing drugs such as zyrtec (cetrizine). I have my doubts wether it will work though, elevated PGd2 in balding scalps doesnt neccessarily mean if we block it, it will cure baldness, there could be hundreds of chemicals elevated in balding scalps.

if interested there is people on hairlosshelp currently trying to block PGD2 topically.

But the landmark study in Science Translational Medicine showed a causal relation. several times elevated PgD2 and it's synthase pgdts in bald scalp was just the start, then they found a few other things: prior to catagen phase even in normal normal pgdts and pgd2 increase in a temporal fashion: that is the catagen follows in time the activity of those (they dont just co-occur, pgdts and pgd increase prior to the resting of the hair... suggest causality, not just correlation), so it appears they are inducing in some way resting phase of the hair, AND finally to really prove causation they showed PGD2 applied to cultured human hair inhibits growth. preventing the PGD2 binding the receptor would very likely positively alter the balding process whether it is by slowing or halting loss, or by facilitating regrowth.

the fellow who sourced our group buy is working on a PgE/PgD balancing solution.

Law, are you going to try OC000459 ?

in time i will try someting to address PGD2. it may be OC, it may be something else.

Hair loss occurs when testosterone levels are uncharacteristically high. I don’t have much info about any PGD2 hair loss cure, but I know that using test boosters such as Ageless Male doesn’t cause any such unwanted side effects. This product raises the levels of free testosterone in the body notching it up just the right bit till it reaches an acceptable range, so you needn’t be too worried about any side effects. You can check out for yourself Ageless Male scam reviews because it only contains natural ingredients that are totally safe and reliable.

piss off u clown, u think merely mentioning a product is going to make us all run out and buy it. get the f*** out of our f***in faces u f***ing clown

Testosterone is likely the precursor that leads to elevated PGD2 levels in scalp follicles. Why? Many FTM transsexuals, under androgen hormone therapy, start suffering from MPB in the same way as normal guys do. Yet prior to the hormone therapy, they grew hair without problems.

If the problem was solely related to PGD2, then wouldn't women suffer from MPB in equal measure to men? Women generally don't suffer from MPB unless there is a marked increase in progesterone or an abnormal production of androgens.

I think that DHT causes overproduction of acidic sebum within the hair follicle; this strong oleic acid then begins to irritate the hair bulge and inflammatory PGD2 targets this region -- destroying hair producing cells within the bulge.

saahil wrote:Guysssss,

Will there ever be a effective cure for baldness??????

Tight Galea, DHT, PGD2,Expansion of skull, Harmones....

will they ever find one?????????


How longggggggggggggggggggggg to waitttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttt?

Simply relaxing the scalp muscles cures it. BUT the only current method PROVEN to work involves Botox..

All these new hair loss ideas like PGD2 and others are guys mixing their own stuff together or are company's selling them?

well, obviously companies are selling the raw ingredients (research chemical supply companies) but people mix their own solutions