Bimatoprost

Bimatoprost encapsulated in a gel vehicle supposedly increase length and thickness of eyelashes. If this is true, how could this substance affect scalp follicles?

I got this from a site on Latanoprost:

Perhaps the most relevant study on the effect of latanoprost on scalp hair growth is the one by Uno et al. who used a macaque model of androgenetic alopecia.

Uno H, Zimbrick M, Albert D, Stjernschantz J. Effect of latanoprost on hair growth in the bald scalp of the stump-tailed Macaque: a pilot study. Acta Derm Venereol (Stockh) 2002;82:7-12.

The results of this well-controlled study (8 monkeys, 4 treated and 4 serving as controls) showed that treatment with 50 mcg/ml latanoprost daily over 5 months caused minimal hair growth, whereas 500 mcg/ml daily over 3 months induced moderate-to-marked hair regrowth. A 5-10 percent rate of conversion of vellus hairs to intermediary or terminal hairs was observed. The vehicle group showed no effect. Stjernschantz found a significant hypertrichotic effect of a selective prostanoid receptor agonist (fluprostenol) on hair growth as determined by measuring the rate of the regrowth of fur in adult male CBA-J mice.

Stjernschantz J. From PGF2a-isopropyl ester to latanoprost: a review of the development of xalatan: the Proctor Lecture. Invest Ophthalmol Vis Sci 2001;42:1134-1145.

Here are the latest studies on this:

Exp Dermatol. 2007 Sep;16(9):762-9.
Prostaglandin metabolism in human hair follicle.
Colombe L, Vindrios A, Michelet JF, Bernard BA.

Centre Charles Zviak, L'Oreal Recherche, 90 rue du Général Roguet, Clichy Cedex, France. lcolombe@rd.loreal.com

Prostaglandins regulate a wide number of physiological functions. Recently PGF(2alpha) analogue such as latanoprost was shown to have a real impact on hair regrowth. The aim of this study was to investigate and describe the expression profile in human hair follicle of prostaglandin metabolism key enzymes, i.e. carbonyl reductase-1 (CBR1), microsomal prostaglandin E synthase-1 (mPGES-1) and microsomal prostaglandin E synthase-2 (mPGES-2), cytosolic prostaglandin E synthase (cPGES), the aldoketoreductase AKR1C1 and the prostaglandin F synthase AKR1C3. Quantitative RT-PCR on plucked hair follicles revealed some sex-related differences, mPGES-2 and AKR1C3 expression levels being higher in women. Cell and hair follicle compartment specificity was investigated using Western blot, PGE(2) and PGF(2alpha) ELISA assays and immunohistochemistry. Most of the hair cell types were endowed with prostaglandin metabolism machinery and were thus able to produce PGE(2) and/or PGF(2alpha). The epithelial part of the hair bulb was identified by immunohistology and EIA assays as the main source of prostaglandin synthesis and interconversion. All these observations support the concept that prostaglandins might be involved in hair growth and differentiation control.

Exp Dermatol. 2008 Jan;17(1):63-72. Epub 2007 Nov 13.
Prostanoid receptors in anagen human hair follicles.
Colombe L, Michelet JF, Bernard BA.

L'Oréal Recherche, Clichy, France.

Prostanoid pathway in hair follicle gained closer attention since trichogenic side-effects on hair growth has been observed concomitantly with prostaglandin F(2alpha) receptor (FP) agonist treatment of intraocular pressure. We thus investigated prostanoid receptor distribution in anagen hair follicle and different cell types from hair and skin. Using RT-PCR, Western blot and immunohistochemistry (IHC), we found that all receptors were present in hair follicle. This data shed new light on an underestimated complex network involved in hair growth control. Indeed most of these receptors showed a wide spectrum of expression in cultured cells and the whole hair follicle. Using IHC, we observed that expression of prostaglandin E(2) receptors (EP(2), EP(3), EP(4)), prostaglandin D(2) receptor (DP(2)), prostanoid thromboxane A(2) receptor (TP) and to a lesser extent EP(1) involved several hair follicle compartments. On the opposite, Prostaglandin I(2) receptor (IP) and DP(1) were more specifically expressed in hair cuticle layer and outer root sheath (ORS) basal layer, respectively. FP expression was essentially restricted to ORS companion layer and dermal papilla (DP). Although extracting a clear functional significance from this intricate network remains open challenge, FP labelling, i.e. could explain the biological effect of PGF(2alpha) on hair regrowth, by directly modulating DP function.

Check this out:

http://www.baldingblog.com/2008/11/11/betamethasone-dipropionate-to-treat-hair-loss/

CausticSymmetry wrote:Check this out:

http://www.baldingblog.com/2008/11/11/betamethasone-dipropionate-to-treat-hair-loss/

OK, so who's going to try it? .

We talked about Bimatoprost back in 2006 on other boards and I bought some from ADC in 2007... still have 2 - 3mL bottles of Lumigan. It has 0.3mg/mL of Bimatoprost which is 200mcg shy of one of the studies mentioned... but they don't say how many Ml were used do they?

Would this actually work on the eyelashes? The product you have, Lumigan, is not in a gel solution?

One of the side effects of just using the drops as intended (in the eye) is often longer lashes, so yes that works. But as specifically an eyelash product you would want a gel to keep it out of your eye and concentrated on the base of the eyelash. From the study you can see that they added Lumigan to Gonak, a common OTC ophthalmic lubricant/excipient. Gonak is 2.5% hydroxypropyl methylcellulose (HPMC), which is hypromellose in an aqueous solution.

http://clinicaltrials.gov/ct2/show/record/NCT00773136?intr=%22Bimatoprost%22&rank=8

"Objective: To determine if Lumigan (bimatoprost) causes increased lash length when used in gel suspension applied to the base of the eyelashes. Methods: Subjects recruited from the Bascom Palmer Eye Institute were screened and those who met inclusion criteria were enrolled. Each participant received two vials of gel suspension, which contained bimatoprost and normal saline, respectively, each mixed 1:1 with GonakTM gel and labeled "right eye" and "left eye" according to randomization. "

Anyone tried this over the years?

Seems boyinhtown got some good results in 19 days.

https://immortalhair.forumotion.com/t8536-order-cheap-latissebimatoprost-here-with-pictures-showing-results

It's super expensive.