Curcumin/Resveratrol Immunosuppression

Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway
S Sharma,* K Chopra,* S K Kulkarni,* and J N Agrewala†
†Immunology Laboratory, Institute of Microbial Technology, Chandigarh, India
*Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
Correspondence: Dr Javed N. Agrewala, Immunology Laboratory, Institute of Microbial Technology, Sector-39 A, Chandigarh-160036, India. E-mail: javed@imtech.res.in
Accepted October 16, 2006.

Abstract
The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)-10.
Keywords: CD28, CD40, CD80, CTLA-4, curcumin, IL-10, resveratrol

Introduction
A faulty immune response plays a pathogenic role in a wide spectrum of inflammatory diseases, including hypersensitivity responses to environmental antigens (allergic disorders), false recognition of self-antigen (autoimmune diseases) and immune attack against alloantigens during transplantation [1,2]. Hence, it becomes crucial to suppress the immune system to control the damage done to the self-tissues. Even though several immunosuppressive drugs are available, their mechanism of action is still not known precisely.
Change in the expression of co-stimulatory molecules, secretion of cytokines and frequency of regulatory T cells can influence the outcome of many diseases. Modulation of the expression of CD28/CTLA-4 can augment or antagonize T cell receptor signalling, and interleukin (IL)-10 is known to restrain the immune responses [3–7].
Resveratrol, present in red grapes, and curcumin in turmeric, suppress the growth of tumour cell lines, induce apoptosis and have potent anti-oxidant properties [8–13]. Because little is known about the mechanism of action of these drugs on the immune system [8,10,13], in the present study we have studied thoroughly the role of curcumin and resveratrol on lymphocyte proliferation and demonstrated for the first time that both these drugs suppress the immune system by controlling mainly the expression of CD28/CTLA-4 and CD80 co-stimulatory molecules.

mphatesmpb wrote:I'm not sure what the consensus is on immunosuppression, but here's the abstract of a study showing that the curcumin/resveratrol combination might cause immunosuppression. This is interesting because several studies have shown that there is an auto-immune component in MPB...researchers believe that microbial colonization of the follicular infundibulum by transient skin flora might result in an inflammatory infiltrate of lymphocytes accumulating around the hair follicles (see thread: https://immortalhair.forumotion.com/t5447-cutaneous-immunopathology-of-androgenetic-alopecia).

Recently I've been applying an aqueous solution of garlic/onion to my scalp every night, as I believe that this will kill the problematic bacteria which might be colonizing the hair follicles.

Abstract:

Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway
S Sharma,* K Chopra,* S K Kulkarni,* and J N Agrewala†
†Immunology Laboratory, Institute of Microbial Technology, Chandigarh, India
*Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
Correspondence: Dr Javed N. Agrewala, Immunology Laboratory, Institute of Microbial Technology, Sector-39 A, Chandigarh-160036, India. E-mail: javed@imtech.res.in
Accepted October 16, 2006.

Abstract
The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)-10.
Keywords: CD28, CD40, CD80, CTLA-4, curcumin, IL-10, resveratrol

Introduction
A faulty immune response plays a pathogenic role in a wide spectrum of inflammatory diseases, including hypersensitivity responses to environmental antigens (allergic disorders), false recognition of self-antigen (autoimmune diseases) and immune attack against alloantigens during transplantation [1,2]. Hence, it becomes crucial to suppress the immune system to control the damage done to the self-tissues. Even though several immunosuppressive drugs are available, their mechanism of action is still not known precisely.
Change in the expression of co-stimulatory molecules, secretion of cytokines and frequency of regulatory T cells can influence the outcome of many diseases. Modulation of the expression of CD28/CTLA-4 can augment or antagonize T cell receptor signalling, and interleukin (IL)-10 is known to restrain the immune responses [3–7].
Resveratrol, present in red grapes, and curcumin in turmeric, suppress the growth of tumour cell lines, induce apoptosis and have potent anti-oxidant properties [8–13]. Because little is known about the mechanism of action of these drugs on the immune system [8,10,13], in the present study we have studied thoroughly the role of curcumin and resveratrol on lymphocyte proliferation and demonstrated for the first time that both these drugs suppress the immune system by controlling mainly the expression of CD28/CTLA-4 and CD80 co-stimulatory molecules.

Somehow, systemic immunosuppression sound like a great idea.

gutted wrote:

mphatesmpb wrote:I'm not sure what the consensus is on immunosuppression, but here's the abstract of a study showing that the curcumin/resveratrol combination might cause immunosuppression. This is interesting because several studies have shown that there is an auto-immune component in MPB...researchers believe that microbial colonization of the follicular infundibulum by transient skin flora might result in an inflammatory infiltrate of lymphocytes accumulating around the hair follicles (see thread: https://immortalhair.forumotion.com/t5447-cutaneous-immunopathology-of-androgenetic-alopecia).

Recently I've been applying an aqueous solution of garlic/onion to my scalp every night, as I believe that this will kill the problematic bacteria which might be colonizing the hair follicles.

Abstract:

Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway
S Sharma,* K Chopra,* S K Kulkarni,* and J N Agrewala†
†Immunology Laboratory, Institute of Microbial Technology, Chandigarh, India
*Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
Correspondence: Dr Javed N. Agrewala, Immunology Laboratory, Institute of Microbial Technology, Sector-39 A, Chandigarh-160036, India. E-mail: javed@imtech.res.in
Accepted October 16, 2006.

Abstract
The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)-10.
Keywords: CD28, CD40, CD80, CTLA-4, curcumin, IL-10, resveratrol

Introduction
A faulty immune response plays a pathogenic role in a wide spectrum of inflammatory diseases, including hypersensitivity responses to environmental antigens (allergic disorders), false recognition of self-antigen (autoimmune diseases) and immune attack against alloantigens during transplantation [1,2]. Hence, it becomes crucial to suppress the immune system to control the damage done to the self-tissues. Even though several immunosuppressive drugs are available, their mechanism of action is still not known precisely.
Change in the expression of co-stimulatory molecules, secretion of cytokines and frequency of regulatory T cells can influence the outcome of many diseases. Modulation of the expression of CD28/CTLA-4 can augment or antagonize T cell receptor signalling, and interleukin (IL)-10 is known to restrain the immune responses [3–7].
Resveratrol, present in red grapes, and curcumin in turmeric, suppress the growth of tumour cell lines, induce apoptosis and have potent anti-oxidant properties [8–13]. Because little is known about the mechanism of action of these drugs on the immune system [8,10,13], in the present study we have studied thoroughly the role of curcumin and resveratrol on lymphocyte proliferation and demonstrated for the first time that both these drugs suppress the immune system by controlling mainly the expression of CD28/CTLA-4 and CD80 co-stimulatory molecules.

Somehow, systemic immunosuppression sound like a great idea.

one thing which i noted when i was eating 1 piece of garlic a day a couple of months back, my head stopped itching and dandruff was low and the greasiness was also low, until i stopped!

one thing which i noted when i was eating 1 piece of garlic a day a couple of months back, my head stopped itching and dandruff was low and the greasiness was also low, until i stopped!

pancacke wrote:

one thing which i noted when i was eating 1 piece of garlic a day a couple of months back, my head stopped itching and dandruff was low and the greasiness was also low, until i stopped!

Candida is associated with dandruff and garlic is a natural antibiotic, my guess is it kept the yeast at bay for the time you took it.

tooyoung wrote:Yeah I thought you had meant to say it doesn't sound good.

CS, any input? Off the top of my head I think I remember you saying something like curcumin/resv are immune modulating rather than supressing, so they would be safe to take? Do you think their anti inflammitory properties are all positive?