Significant association between urine antimony, cobalt, cadmium and tungsten with cerebro/cardiovascular disease was observed

http://content.onlinejacc.org/cgi/reprint/55/10_MeetingAbstracts/A177.E1658.pdf

Chronic heavy metal exposure is thought to play a role in pathogenesis of composite cardiovascular and cerebrovascular disease (CCVD). We aim to study the association between CCVD and long-term heavy metal exposure assessed using urine metal concentration.

Results: Statistically signiicant associations between CCVD and four heavy metals were observed: antimony [adjusted OR: 2.15 (95% CI: 1.45 - 3.18)]; cadmium [adjusted OR: 2.35 (95% CI: 1.47 - 3.75)]; cobalt [adjusted OR: 2.09 (95% CI: 1.22 - 3.60)]; tungsten [adjusted OR: 1.78 (95% CI: 1.28 - 2.48)].

Conclusions: Significant association between urine antimony, cobalt, cadmium and Tungsten with cerebro/cardiovascular disease was observed. The persistence of association even after adjustment for glomerular iltration rate and C reactive protein suggests that mechanisms other than impaired renal function and inflammation are involved in pathogenesis of atherosclerosis.