Ketoconazole inhibits DHT and Estradiol from binding with SHBG.

Any opinion from CS on the matter? I'm strongly tempted to get some.

maybe I missed it, but what is PO and ZP?

tao81 wrote:If you look closer to the studies, you´ll see that PO and ZP have the same effect on hair as keto. PO even outperformed keto. I think the androgen effect of keto is way to weak for real MPB and the positive effects are due to antifungual and thus antiinflamatory actions.

I've been using 1% every time I have showered. Really hasn't done anything, keep shedding.

2%+ worthwhile?

Balthier - Piroctone Olamine‎ and Zinc Pyrithione. Both used in shampoos. Give them a quick Google.

Does anyone here have any experiences with either of these?

C. Piérard-Franchimont, V. Goffin, F. Henry, I. Uhoda, C. Braham, G. E. Piérard.

Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations.

International Journal of Cosmetic Science Volume 24, Issue 5, Page 249-256, Oct 2002

Synopsis

Hair shedding and hair thinning have been reported to be affected by dandruff and seborrhoeic dermatitis. The present study was conducted in 150 men presenting with telogen effluvium related to androgenic alopecia associated with dandruff. They were randomly allocated to three groups receiving each one of the three shampoos in the market containing either 1% ketoconazole (KTZ), 1% piroctone olamine (PTO) or 1% zinc pyrithione (ZPT). Shampoos had to be used 2-3 times a week for 6 months. Hair shedding during shampoo was evaluated semiquantitatively. Hair density on the vertex was evaluated on photographs using a Dermaphot. Trichograms were used for determining the anagen hair percentage and the mean proximal hair shaft diameter using computerized image analysis. The sebum excretion rate (SER, g cm2 h1) was also measured using a Sebumeter®.
The three treatments cleared pruritus and dandruff rapidly. At end point, hair density was unchanged, although hair shedding was decreased (KTZ: -17.3%, PTO: -16.5%, ZPT: -10.1%) and the anagen hair percentage was increased (KTZ: 4.9%, PTO: 7.9%, ZPT: 6.8%). The effect on the mean hair shaft diameter was contrasted between the three groups of volunteers (KTZ: 5.4%, PTO: 7.7%, ZPT: -2.2%). In conclusion, telogen effluvium was controlled by KTZ, PTO and ZPT shampoos at 1% concentration. In addition, KTZ and PTO increased the mean hair shaft thickness while discretely decreasing the sebum output at the skin surface.

From the full study:

Conclusion

The present study comparing 1% KTZ, 1% PTO and 1% ZPT shampoos has demonstrated that these products have some other benefits in addition to their reported antidandruff effect. The data show that these shampoos have a beneficial effect on the anagen/ telogen ratio, by increasing the anagen hair percentage in subjects with dandruff. This results in a reduced hair shedding. In addition, the data show that 1% KTZ and 1% PTO, but not 1% ZPT, produce a beneficial effect on scalp seborrhoea and hair shaft diameter. The reason for such opposite effect is unknown. Finally, the data show that scalp seborrhoea is inversely correlated with hair thickness. The virtue of such a finding is its simplicity. However, the results cannot be taken at face value. There may remain debate whether reducing sebum excess on the scalp may lead to thicker hair, and whether increasing scalp seborrhoea may be accompanied by a reduction in the hair shaft diameter.

How long do you leave the keto cream/foam on for?

What do you lot use to moisturise and stop the hair and scalp getting ridiculously dry?

Ordered some Keto cream today and plan on using it maybe once a day. Again mainly targeting the vertex and hairline. Will test a little to see how I react to it first but only plan on using a small amount when applying it

Joey - How long will you be leaving it on your head?

Planning on using it in the morning and washing my hair in the evening. Again, im not planning on lacing my scalp with the stuff, just targeting my vertex (patch has developed and getting worse) and hairline at the moment. I'm also going to give topical spiro and topical miconazole ago. Thinking of using the following regime with regards to topicals:

Keto cream EOD
Miconazole EOD
Topical Spiro every night before bed

I may even toy with the possibility of using Keto just on the vertex and Miconazole on the hairline to give a better idea of effectiveness. Think these creams can be quite harsh on skin so will also be taking a break now and again depending on how things pan out.

Alongside that i've also cleaned up my diet a fair bit and now try and eat 'simple' foods where possible. Also on the IH top 6 and use a laser helmet as well. Also apply Super Zix which I find reduces shedding for me. Tried Folligen, Tricomin - cosmetic effect on hair is good, but, for me anyway, don't think they were providing any benefit to the underlying problem of MPB. Minox is a no-no for me, tried it a few years back, and itch I got from it was unbearable. Fin and Dut are treatments which I don't want to use.

So you'll be having the cream on for around 10 hours? Isn't that way too long?

Again, i'm going to apply a very thin layer to a small area and I believe 8-10 hours shouldn't be a problem