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PM, 7-HMR= Gyno but are Anti-Aromatase Estrogen Balancers

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PM, 7-HMR= Gyno but are Anti-Aromatase Estrogen Balancers Empty PM, 7-HMR= Gyno but are Anti-Aromatase Estrogen Balancers

Post  DM5 Sun Sep 06, 2009 6:46 pm

I don't get it. Why are people getting Gyno and low libido if both 7-hmr and Puerira Muerifica are supposed to balance Estrogen and inhibit Aromatase? It would seem that they are allowing negative Estrogen to dominate. If they are Anti-Aromatase, they should guard against these side effects. If they balance Estrogen, there should be no negative estrogen. Can someone shed some light on this one?
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Post  CausticSymmetry Sun Sep 06, 2009 8:16 pm

danmrtini - 7-HMR is more of an anti-aromatase. Pueraria Mirifica is pro-estrogenic. There is another species of kudzu, called Pueraria Lobata which is anti-aromatase, so maybe that is causing the confusion.

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Post  DM5 Mon Sep 07, 2009 2:23 am

I am referring to the reports of users experiencing Gyno and low libido on both. If that is the case what would be causing these sides?
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Post  CausticSymmetry Mon Sep 07, 2009 1:51 pm

danmrtini - Pueraria Mirifica contains a molecule that is virtually identical to human estriol, one of the safer estrogens. However, it appears that it decreases DHT levels too much and so like dutasteride it can lead to gyno.

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Post  JJB9050 Mon Sep 07, 2009 2:02 pm

Is PM still being suggested by users here? I'd like to try dosing 500mg every other day to push my body in the right direction without risking side effects.

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Post  Gibson Mon Sep 07, 2009 3:41 pm

7-HMR is anti-estrogen, cannot cause gyno.

PM is straight-up estrogen. BE CAREFUL!!!

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Post  DM5 Tue Sep 08, 2009 11:09 am

Just wondering if a dose of 1 every or EOD of PM might not give sides. Then again if this is like Fin or Dut, your results will be proportionate to your sides. If that is the case it might seem better to take both 7-hmr and PM and see if a balance and not just a cancellation can be struck.
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Post  baller234 Thu Sep 16, 2010 1:47 am

Sorry for the old post but does PM affect aromatase at all? Also how does it decrease DHT?

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Post  baller234 Thu Sep 16, 2010 1:58 am

My understanding of it was that it lowers estradiol by promoting its metabolism into estriol and the beneficial hydroxy metabolites but it doesn't affect aromatse. Also since it doesn't effect 5ar does it block the androgen receptor?

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Post  medohat Sat Sep 18, 2010 7:36 am

Pump

I am with baller234 on his questions someone answer plz . thanks for this great forum.
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Post  baller234 Sat Sep 18, 2010 11:45 am

I've looked everywhere and couldn't find anything about PM affecting aromatase or androgens. From what I understand, all it does is interact with the estrogen receptor and SHBG. Any effect on androgens would be a result of displacing sex hormones from SHBG. Am I far off the mark CS?

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Post  Amaranthaceae Sat Sep 18, 2010 11:20 pm

It is my impression that P. Mirifica will lower T in males.

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Post  baller234 Sun Sep 19, 2010 2:27 pm

Well then it certainly isn't inhibiting aromatase. When the aromatase enzyme is inhibited, testosterone goes up. I think in small amounts, PM will increase testosterone because it lowers estradiol but if you take enough of it so that the total estrogenic load in your body is higher than before, then it will lower LH and testosterone.

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Post  DM5 Sun Sep 19, 2010 6:35 pm

Baller234-

My impression from my 8 month stint with PM is that initially I felt an Androgen boost, much like with Finasteride and then after a about a month, Estrogen kicked in. Although I feel like I retain hair much better when hormones are in favor of Estrogen, I don't feel good mentally or physically. That's why I quit. Though, I think Immortal is right that when insulin is balanced, running pro-androgen won't affect mpb. I have experienced this a couple times after I really had things in line.
I agree with what you said and from my experience and what I've read, I'm pretty sure PM doesn't inhibit aromatase.

BTW- good to have you over here from HLH. Your a sharp guy, I remember bringing up PM over on HLH and the providing links to this forum. I think I remember you were in that thread. Hairy Gary was pushing Birth Control pills to the newbs.

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