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Minoxidil Alternative + SULT1A1 Enzyme Booster

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minoxidil - Minoxidil Alternative + SULT1A1 Enzyme Booster Empty Minoxidil Alternative + SULT1A1 Enzyme Booster

Post  MikeGore Sat May 13, 2023 11:44 pm

If we look at the mechanism of action as described in Wikipedia:

The mechanism by which minoxidil promotes hair growth is not fully understood. Minoxidil is an adenosine 5'-triphosphate-sensitive potassium channel opener,[24] causing hyperpolarization of cell membranes. Theoretically, by widening blood vessels and opening potassium channels, it allows more oxygen, blood, and nutrients to the follicles. Moreover, minoxidil contains a nitric oxide moiety and may act as a nitric oxide agonist. This may cause follicles in the telogen phase to shed, which are then replaced by thicker hairs in a new anagen phase. Minoxidil is a prodrug that is converted by sulfation via the sulfotransferase enzyme SULT1A1 to its active form, minoxidil sulfate. The effect of minoxidil is mediated by adenosine, which triggers intracellular signal transduction via both adenosine A1 receptors and two sub-types of adenosine A2 receptors (A2A and A2B receptors).[25] Minoxidil acts as an activator of the Kir6/SUR2 channel upon selective binding to SUR2.[26] The expression of SUR2B in dermal papilla cells might play a role in the production of adenosine.[25] Minoxidil induces cell growth factors such as VEGF, HGF, IGF-1 and potentiates HGF and IGF-1 actions by the activation of uncoupled sulfonylurea receptor on the plasma membrane of dermal papilla cells.[27]

Can we imitate that by using something else? But then again if everything is imitated the side effects will probably be the same as well. But namely looking for something that is a:

  • Potassium Channel Opener
  • Nitric Oxide Agonist
  • Induces VEGF, HGF, IGF-1
  • Activates Kir6/SUR2 channel upon selective binding to SUR2
  • Induces prostaglandin E2 production by activating COX-1 and prostaglandin endoperoxide synthase-1 but inhibits prostacyclin production

Also sulfotransferase enzyme SULT1A1 seems like an important part of minoxidils efficacy for people that respond well to it. Considering the potential side effects of minoxidil and the benefit of Sulfotransferase Enzyme would there any beneficial value to using a SULT1A1 Enzyme Booster by itself? Is there any reason to think that SULT1A1 Enzyme Booster by itself can benefit the hair? Also a SULT1A1 Enzyme Booster actually have any side effects?

It's amazing that minoxidil is been on the market for such a long time, but yet there doesn't seem to be a product with is Minoxidil minus the side effects.

MikeGore

Posts : 803
Join date : 2010-05-25

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