Search
Check Out Our Sponsors
Latest topics
Minoxidil Alternative + SULT1A1 Enzyme Booster
Page 1 of 1
Minoxidil Alternative + SULT1A1 Enzyme Booster
If we look at the mechanism of action as described in Wikipedia:
Can we imitate that by using something else? But then again if everything is imitated the side effects will probably be the same as well. But namely looking for something that is a:
Also sulfotransferase enzyme SULT1A1 seems like an important part of minoxidils efficacy for people that respond well to it. Considering the potential side effects of minoxidil and the benefit of Sulfotransferase Enzyme would there any beneficial value to using a SULT1A1 Enzyme Booster by itself? Is there any reason to think that SULT1A1 Enzyme Booster by itself can benefit the hair? Also a SULT1A1 Enzyme Booster actually have any side effects?
It's amazing that minoxidil is been on the market for such a long time, but yet there doesn't seem to be a product with is Minoxidil minus the side effects.
The mechanism by which minoxidil promotes hair growth is not fully understood. Minoxidil is an adenosine 5'-triphosphate-sensitive potassium channel opener,[24] causing hyperpolarization of cell membranes. Theoretically, by widening blood vessels and opening potassium channels, it allows more oxygen, blood, and nutrients to the follicles. Moreover, minoxidil contains a nitric oxide moiety and may act as a nitric oxide agonist. This may cause follicles in the telogen phase to shed, which are then replaced by thicker hairs in a new anagen phase. Minoxidil is a prodrug that is converted by sulfation via the sulfotransferase enzyme SULT1A1 to its active form, minoxidil sulfate. The effect of minoxidil is mediated by adenosine, which triggers intracellular signal transduction via both adenosine A1 receptors and two sub-types of adenosine A2 receptors (A2A and A2B receptors).[25] Minoxidil acts as an activator of the Kir6/SUR2 channel upon selective binding to SUR2.[26] The expression of SUR2B in dermal papilla cells might play a role in the production of adenosine.[25] Minoxidil induces cell growth factors such as VEGF, HGF, IGF-1 and potentiates HGF and IGF-1 actions by the activation of uncoupled sulfonylurea receptor on the plasma membrane of dermal papilla cells.[27]
Can we imitate that by using something else? But then again if everything is imitated the side effects will probably be the same as well. But namely looking for something that is a:
- Potassium Channel Opener
- Nitric Oxide Agonist
- Induces VEGF, HGF, IGF-1
- Activates Kir6/SUR2 channel upon selective binding to SUR2
- Induces prostaglandin E2 production by activating COX-1 and prostaglandin endoperoxide synthase-1 but inhibits prostacyclin production
Also sulfotransferase enzyme SULT1A1 seems like an important part of minoxidils efficacy for people that respond well to it. Considering the potential side effects of minoxidil and the benefit of Sulfotransferase Enzyme would there any beneficial value to using a SULT1A1 Enzyme Booster by itself? Is there any reason to think that SULT1A1 Enzyme Booster by itself can benefit the hair? Also a SULT1A1 Enzyme Booster actually have any side effects?
It's amazing that minoxidil is been on the market for such a long time, but yet there doesn't seem to be a product with is Minoxidil minus the side effects.
MikeGore- Posts : 803
Join date : 2010-05-25
Similar topics
» Minoxidil alternative
» CS need your help! Minoxidil - How does it work and what is the alternative?
» Adenosine with Dermaneedling is a good alternative to Minoxidil
» Selling potent Copper Peptides AHK-CU - Growth stimulator, an alternative to Minoxidil
» Hair growth using dermarolling + minoxidil 4x greater than minoxidil alone
» CS need your help! Minoxidil - How does it work and what is the alternative?
» Adenosine with Dermaneedling is a good alternative to Minoxidil
» Selling potent Copper Peptides AHK-CU - Growth stimulator, an alternative to Minoxidil
» Hair growth using dermarolling + minoxidil 4x greater than minoxidil alone
Page 1 of 1
Permissions in this forum:
You cannot reply to topics in this forum
|
|
Yesterday at 4:00 pm by CausticSymmetry
» *The first scientific evidence in 2021 that viruses do not exist*
Fri Apr 26, 2024 12:44 pm by CausticSymmetry
» Potential Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells
Wed Apr 17, 2024 7:44 am by CausticSymmetry
» Breast Biopsy
Sun Apr 14, 2024 2:23 am by shaftless
» Sorry if brought up before but: Best topical to help aid in breaking up fibrosis?
Sat Apr 13, 2024 2:51 am by Hoppipolla
» solar eclipse on april 8
Thu Apr 11, 2024 4:04 am by shaftless
» Role and Mechanisms of Phytochemicals in Hair Growth and Health
Wed Apr 10, 2024 4:20 am by CausticSymmetry
» IH Regimen
Tue Apr 09, 2024 4:25 pm by CF
» Exosome Theory and Herpes
Mon Apr 08, 2024 11:16 am by MikeGore